CD117 (c-Kit) Monoclonal Antibody (104D2), PE, eBioscience™ | Invitrogen 12-1178-41 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD117 (c-Kit) Monoclonal Antibody (104D2), PE, eBioscience™

catalog :

12-1178-41

quantity :

25 Tests

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

104D2

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s1a	Gao X, Lee H, Li W, Platt R, Barrasa M, Ma Q, et al. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proc Natl Acad Sci U S A. 2017;114:10107-10112 pubmed publisher
flow cytometry; human; tbl 1	Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol. 2014;15:354-364 pubmed publisher
	Sahabian A, Sgodda M, Naujok O, Dettmer R, Dahlmann J, Manstein F, et al. Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential. Cells. 2019;8: pubmed publisher
	Vanuytsel K, Matte T, Leung A, Naing Z, Morrison T, Chui D, et al. Induced pluripotent stem cell-based mapping of β-globin expression throughout human erythropoietic development. Blood Adv. 2018;2:1998-2011 pubmed publisher
	Mitchell K, Barreyro L, Todorova T, Taylor S, Antony Debré I, Narayanagari S, et al. IL1RAP potentiates multiple oncogenic signaling pathways in AML. J Exp Med. 2018;215:1709-1727 pubmed publisher
	Lee H, Gao X, Barrasa M, Li H, Elmes R, Peters L, et al. PPAR-Î± and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal. Nature. 2015;522:474-7 pubmed publisher
	Russell S, Lechner M, Gong L, Megiel C, Liebertz D, Masood R, et al. USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011;47:810-7 pubmed publisher
	Serbina N, Hohl T, Cherny M, Pamer E. Selective expansion of the monocytic lineage directed by bacterial infection. J Immunol. 2009;183:1900-10 pubmed publisher
	Chiba H, Ishii G, Ito T, Aoyagi K, Sasaki H, Nagai K, et al. CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. Stem Cells. 2008;26:2523-30 pubmed publisher
	Biedermann B, Gil D, Bowen D, Crocker P. Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res. 2007;31:211-20 pubmed

product information

Product Type :

Antibody

Product Name :

CD117 (c-Kit) Monoclonal Antibody (104D2), PE, eBioscience™

Catalog # :

12-1178-41

Quantity :

25 Tests

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human

Clone :

104D2

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W

more info or order :

Invitrogen product webpage