This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD117 (c-Kit) Monoclonal Antibody (ACK2), PE, eBioscience
catalog :
12-1172-82
quantity :
100 ug
price :
US 258.00
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
ACK2

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 105
Reference
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Huang Z, Ruan H, Zhang Z, Chen W, Lin Z, Zeng H, et al. Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. Am J Pathol. 2014;184:122-32 pubmed publisher
Li X, Xue H, Kang Q, Sun H, Yang S, Zhang G, et al. Alterations of the interstitial cells of Cajal and the microstructure of the gastrointestinal tract in KIT distal kinase mutant mice. Cell Tissue Res. 2014;355:49-58 pubmed publisher
Langford Smith K, Sandiford Z, Langford Smith A, Wilkinson F, Jones S, Wraith J, et al. Signal one and two blockade are both critical for non-myeloablative murine HSCT across a major histocompatibility complex barrier. PLoS ONE. 2013;8:e77632 pubmed publisher
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Wu C, Lin Y, Gao J, Winston J, Cheng L, Shi X. Are interstitial cells of Cajal involved in mechanical stress-induced gene expression and impairment of smooth muscle contractility in bowel obstruction?. PLoS ONE. 2013;8:e76222 pubmed publisher
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Michel A, Schuler A, Friedrich P, Döner F, Bopp T, Radsak M, et al. Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells. J Immunol. 2013;190:5534-44 pubmed publisher
Lee J, Kim S, Kwon Y, Kim B, So I. Characteristics of the cholecystokinin-induced depolarization of pacemaking activity in cultured interstitial cells of Cajal from murine small intestine. Cell Physiol Biochem. 2013;31:542-54 pubmed publisher
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Smith K, Harcus Y, Garbi N, Hämmerling G, MacDonald A, Maizels R. Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion. Infect Immun. 2012;80:3481-9 pubmed publisher
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He X, Yang W, Wen X, Tang D, Xiao L, Han J, et al. Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence. Cells Tissues Organs. 2012;196:175-88 pubmed publisher
Treviño Villarreal J, Cotanche D, Sepúlveda R, Bortoni M, Manneberg O, Udagawa T, et al. Host-derived pericytes and Sca-1+ cells predominate in the MART-1- stroma fraction of experimentally induced melanoma. J Histochem Cytochem. 2011;59:1060-75 pubmed publisher
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed publisher
Tashiro K, Kawabata K, Omori M, Yamaguchi T, Sakurai F, Katayama K, et al. Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction. Stem Cell Res. 2012;8:300-11 pubmed publisher
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Ding X, Lin Q, Ensenat Waser R, Rose John S, Zenke M. Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells. Stem Cells Dev. 2012;21:121-32 pubmed publisher
Takaki M, Misawa H, Matsuyoshi H, Kawahara I, Goto K, Zhang G, et al. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation. Biochem Biophys Res Commun. 2011;406:529-33 pubmed publisher
Zhou Y, He Y, Chen C, Ji J, Niu J, Wang H, et al. Time-specific blockade of PDGFR with Imatinib (Glivec®) causes cataract and disruption of lens fiber cells in neonatal mice. Virchows Arch. 2011;458:349-56 pubmed publisher
Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D. Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010;137:3941-52 pubmed publisher
Huang Y, Li F, Tong W, Zhang A, He Y, Fu T, et al. Hydrogen sulfide, a gaseous transmitter, stimulates proliferation of interstitial cells of Cajal via phosphorylation of AKT protein kinase. Tohoku J Exp Med. 2010;221:125-32 pubmed
Dixon R, Ramsey K, Schripsema J, Sanders K, Ward S. Time-dependent disruption of oviduct pacemaker cells by Chlamydia infection in mice. Biol Reprod. 2010;83:244-53 pubmed publisher
Liu D, Wang F, Zou Z, Dong S, Wang J, Ran X, et al. Bone marrow derivation of interstitial cells of cajal in small intestine following intestinal injury. J Biomed Biotechnol. 2010;2010:164986 pubmed publisher
Tong W, Jia H, Zhang L, Li C, Ridolfi T, Liu B. Exogenous stem cell factor improves interstitial cells of Cajal restoration after blockade of c-kit signaling pathway. Scand J Gastroenterol. 2010;45:844-51 pubmed publisher
Tharayil V, Wouters M, Stanich J, Roeder J, Lei S, Beyder A, et al. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil. 2010;22:462-9, e109-10 pubmed publisher
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Mei F, Guo S, He Y, Zhu J, Zhou D, Niu J, et al. Apoptosis of interstitial cells of Cajal, smooth muscle cells, and enteric neurons induced by intestinal ischemia and reperfusion injury in adult guinea pigs. Virchows Arch. 2009;454:401-9 pubmed publisher
Yu B, Han J, He Y, Guo S, Li S, Mei F. Immunohistochemical study of CD44 immunopositive cells in the muscular layers of the gastrointestinal tract in adult guinea pigs and mice. Acta Histochem. 2009;111:382-90 pubmed publisher
Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature. 2009;457:892-5 pubmed publisher
Erler J, Bennewith K, Cox T, Lang G, Bird D, Koong A, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 2009;15:35-44 pubmed publisher
Babbe H, McMenamin J, Hobeika E, Wang J, Rodig S, Reth M, et al. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol. 2009;182:347-60 pubmed
Naito T, Shiohara T, Hibi T, Suematsu M, Ishikawa H. ROR gamma t is dispensable for the development of intestinal mucosal T cells. Mucosal Immunol. 2008;1:198-207 pubmed publisher
Mei F, Zhu J, Guo S, Zhou D, Han J, Yu B, et al. An age-dependent proliferation is involved in the postnatal development of interstitial cells of Cajal in the small intestine of mice. Histochem Cell Biol. 2009;131:43-53 pubmed publisher
Wallace G, Lapidos K, Kenik J, McNally E. Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy. Am J Pathol. 2008;173:792-802 pubmed publisher
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Huang Y, Mei F, Yu B, Zhang H, Han J, Jiang Z, et al. Distribution of the interstitial Cajal-like cells in the gallbladder and extrahepatic biliary duct of the guinea-pig. Acta Histochem. 2009;111:157-65 pubmed publisher
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Ullrich E, Bonmort M, Mignot G, Jacobs B, Bosisio D, Sozzani S, et al. Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. J Immunol. 2008;180:7887-97 pubmed
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Nakai N, Ishikawa T, Nishitani A, Liu N, Shincho M, Hao H, et al. A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J Pathol. 2008;214:302-11 pubmed
Edry E, Koralov S, Rajewsky K, Melamed D. Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement. J Immunol. 2007;179:6555-60 pubmed
Onai N, Obata Onai A, Schmid M, Ohteki T, Jarrossay D, Manz M. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007;8:1207-16 pubmed
Thomas F, Ismail R, Jiang J, Vanderhyden B. Kit ligand 2 promotes murine oocyte growth in vitro. Biol Reprod. 2008;78:167-75 pubmed
Chen H, ORDOG T, Chen J, YOUNG D, Bardsley M, Redelman D, et al. Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine. Physiol Genomics. 2007;31:492-509 pubmed
Wouters M, Gibbons S, Roeder J, Distad M, Ou Y, Strege P, et al. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology. 2007;133:897-906 pubmed
Na Y, Baek H, Ahn S, Shin H, Chang I, Hwang J. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol. 2007;74:780-6 pubmed
Lu M, Glover C, Tien A, Humphries R, Piret J, Helgason C. Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality. Exp Hematol. 2007;35:1293-302 pubmed
Takaki M, Misawa H, Shimizu J, Kuniyasu H, Horiguchi K. Inhibition of gut pacemaker cell formation from mouse ES cells by the c-kit inhibitor. Biochem Biophys Res Commun. 2007;359:354-9 pubmed
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten L, Ceredig R, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 2007;26:643-54 pubmed
Heib V, Becker M, Warger T, Rechtsteiner G, Tertilt C, Klein M, et al. Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice. Blood. 2007;110:946-53 pubmed
Mortaz E, Redegeld F, Dunsmore K, Odoms K, Wong H, Nijkamp F, et al. Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid. Eur J Pharmacol. 2007;561:214-9 pubmed
Chen H, Redelman D, Ro S, Ward S, ORDOG T, Sanders K. Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine. Am J Physiol Cell Physiol. 2007;292:C497-507 pubmed
Mei F, Yu B, Ma H, Zhang H, Zhou D. Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs. Virchows Arch. 2006;449:348-57 pubmed
Takaki M, Nakayama S, Misawa H, Nakagawa T, Kuniyasu H. In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. Stem Cells. 2006;24:1414-22 pubmed
Kaplan R, Riba R, Zacharoulis S, Bramley A, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820-7 pubmed
Kim B, Lim H, Yang D, Jun J, Chang I, Park C, et al. Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology. 2005;129:1504-17 pubmed
Tussiwand R, Onai N, Mazzucchelli L, Manz M. Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity. J Immunol. 2005;175:3674-80 pubmed
Nakayama S, Ohya S, Liu H, Watanabe T, Furuzono S, Wang J, et al. Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility. J Cell Sci. 2005;118:4163-73 pubmed
Liu M, Geddis M, Wen Y, Setlik W, Gershon M. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2005;289:G1148-63 pubmed
Nakagawa T, Ueshima S, Fujii H, Nakajima Y, Takaki M. Different modulation of spontaneous activities by nitrergic inhibitory nerves between ileum and jejunum in W/Wv mutant mice. Auton Neurosci. 2005;119:25-35 pubmed
Terauchi A, Kobayashi D, Mashimo H. Distinct roles of nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation. Am J Physiol Gastrointest Liver Physiol. 2005;289:G291-9 pubmed
Taghon T, David E, Zuniga Pflucker J, Rothenberg E. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 2005;19:965-78 pubmed
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Liu H, Ohya S, Furuzono S, Wang J, Imaizumi Y, Nakayama S. Co-contribution of IP3R and Ca2+ influx pathways to pacemaker Ca2+ activity in stomach ICC. J Biol Rhythms. 2005;20:15-26 pubmed
Cobas M, Wilson A, Ernst B, Mancini S, MacDonald H, Kemler R, et al. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med. 2004;199:221-9 pubmed
Prasanth S, Ali S. Expression of proto-oncogene c-kit receptor in rats (Rattus norvegicus) and identification of a mutant mRNA transcript implicated in spermatogenic failure. DNA Cell Biol. 2003;22:447-56 pubmed
Sakata S, Sakamaki K, Watanabe K, Nakamura N, Toyokuni S, Nishimune Y, et al. Involvement of death receptor Fas in germ cell degeneration in gonads of Kit-deficient Wv/Wv mutant mice. Cell Death Differ. 2003;10:676-86 pubmed
Kim H, Shin H, Lee E. Morphological alterations in rat peritoneal mast cells by stem cell factor. Immunology. 1998;94:242-6 pubmed
Ismail R, Okawara Y, Fryer J, Vanderhyden B. Hormonal regulation of the ligand for c-kit in the rat ovary and its effects on spontaneous oocyte meiotic maturation. Mol Reprod Dev. 1996;43:458-69 pubmed
product information
Product Type :
Antibody
Product Name :
CD117 (c-Kit) Monoclonal Antibody (ACK2), PE, eBioscience
Catalog # :
12-1172-82
Quantity :
100 ug
Price :
US 258.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 ug/test
Species :
Mouse
Clone :
ACK2
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 ug/test
Aliases :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA