CD70 Monoclonal Antibody (FR70), PE, eBioscience™ | Invitrogen 12-0701-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD70 Monoclonal Antibody (FR70), PE, eBioscience™

catalog :

12-0701-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

FR70

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig e5c	Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
	Autengruber A, Gereke M, Hansen G, Hennig C, Bruder D. Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function. Eur J Microbiol Immunol (Bp). 2012;2:112-20 pubmed publisher
	Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, et al. Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models. J Innate Immun. 2014;6:293-305 pubmed publisher
	McKee A, Burchill M, Munks M, Jin L, Kappler J, Friedman R, et al. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A. 2013;110:E1122-31 pubmed publisher
	Hagman D, Kuzma J, Larson I, Foster Schubert K, Kuan L, Cignarella A, et al. Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processing. J Immunol Methods. 2012;386:50-9 pubmed publisher
	Vicetti Miguel R, Hendricks R, Aguirre A, Melan M, Harvey S, Terry Allison T, et al. Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection. J Immunol. 2012;189:3449-61 pubmed
	Bak S, Barnkob M, Bai A, Higham E, Wittrup K, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189:1708-16 pubmed publisher
	Nesbeth Y, Martinez D, Toraya S, Scarlett U, Cubillos Ruiz J, Rutkowski M, et al. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol. 2010;184:5654-62 pubmed publisher
	Frasca L, Stonier S, Overwijk W, Schluns K. Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol. 2010;88:69-78 pubmed publisher
	McWilliams J, Sanchez P, Haluszczak C, Gapin L, Kedl R. Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity. Vaccine. 2010;28:1468-76 pubmed publisher
	Miller J, Eisele G, Tabatabai G, Aulwurm S, von Kürthy G, Stitz L, et al. Soluble CD70: a novel immunotherapeutic agent for experimental glioblastoma. J Neurosurg. 2010;113:280-5 pubmed publisher
	Middendorp S, Xiao Y, Song J, Peperzak V, Krijger P, Jacobs H, et al. Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma. Blood. 2009;114:2280-9 pubmed publisher
	McEarchern J, Smith L, McDonagh C, Klussman K, Gordon K, Morris Tilden C, et al. Preclinical characterization of SGN-70, a humanized antibody directed against CD70. Clin Cancer Res. 2008;14:7763-72 pubmed publisher
	Heffner M, Fearon D. Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte. Proc Natl Acad Sci U S A. 2007;104:13414-9 pubmed
	Keller A, Groothuis T, Veraar E, Marsman M, Maillette de Buy Wenniger L, Janssen H, et al. Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A. 2007;104:5989-94 pubmed
	Akiba H, Oshima H, Takeda K, Atsuta M, Nakano H, Nakajima A, et al. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol. 1999;162:7058-66 pubmed
	Oshima H, Nakano H, Nohara C, Kobata T, Nakajima A, Jenkins N, et al. Characterization of murine CD70 by molecular cloning and mAb. Int Immunol. 1998;10:517-26 pubmed

product information

Product Type :

Antibody

Product Name :

CD70 Monoclonal Antibody (FR70), PE, eBioscience™

Catalog # :

12-0701-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test

Species :

Mouse

Clone :

FR70

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test

Aliases :

CD27 ligand; Cd27l; CD27-L; CD27LG; CD70; CD70 antigen; Cd70 molecule; Ki-24 antigen; surface antigen CD70; Tnfsf7; TNLG8A; tumor necrosis factor (ligand) superfamily, member 7; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7

more info or order :

Invitrogen product webpage