CD68 Monoclonal Antibody (eBioY1/82A (Y1/82A)), PE, eBioscience | Invitrogen 12-0689-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD68 Monoclonal Antibody (eBioY1/82A (Y1/82A)), PE, eBioscience

catalog :

12-0689-42

quantity :

100 Tests

price :

US 342.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

eBioY1/82A (Y1/82A)

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 27

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:20; loading ...; fig 4a	Hong D, Ding J, Li O, He Q, Ke M, Zhu M, et al. Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection. Stem Cell Res Ther. 2018;9:49 pubmed publisher
flow cytometry; human; loading ...; fig s3a	Taylor J, Cash M, Santostefano K, Nakanishi M, Terada N, Wallet M. CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. J Leukoc Biol. 2018;: pubmed publisher
flow cytometry; human; fig 6a	Garcia Mesa Y, Jay T, Checkley M, Luttge B, Dobrowolski C, Valadkhan S, et al. Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. J Neurovirol. 2017;23:47-66 pubmed publisher
	Le Y, Gao H, Le J, Hornick J, Bleday R, Wee J, et al. VentX promotes tumor specific immunity and efficacy of immune checkpoint inhibitors. iScience. 2024;27:108731 pubmed publisher
	Zhang J, Yuan Z, Li X, Wang F, Wei X, Kang Y, et al. Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection. Life Sci Alliance. 2023;6: pubmed publisher
	Mou J, Zheng W, Wei D, Li D, Fan R, Tang Q. CD200-CD200R affects cisplatin and paclitaxel sensitivity by regulating cathepsin K-mediated p65 NF-κB signaling in cervical cancer. Heliyon. 2023;9:e19220 pubmed publisher
	Zhou B, Xu Y, Xu L, Kong Y, Li K, Chen B, et al. Inhibition of inflammation and infiltration of M2 macrophages in NSCLC through the ATF3/CSF1 axis: Role of miR-27a-3p. Int J Exp Pathol. 2023;104:292-303 pubmed publisher
	Wu H, Liu K, Zhang J. LINC00240/miR-155 axis regulates function of trophoblasts and M2 macrophage polarization via modulating oxidative stress-induced pyroptosis in preeclampsia. Mol Med. 2022;28:119 pubmed publisher
	Zhang H, Wang Y, Zhao Y, Liu T, Wang Z, Zhang N, et al. PTX3 mediates the infiltration, migration, and inflammation-resolving-polarization of macrophages in glioblastoma. CNS Neurosci Ther. 2022;28:1748-1766 pubmed publisher
	Lai C, Tseng P, Chen C, Satria R, Wang Y, Lin C. Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages. J Inflamm Res. 2021;14:5241-5249 pubmed publisher
	Schmitz T, Jannasch M, Weigel T, Moseke C, Gbureck U, Groll J, et al. Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages. Materials (Basel). 2020;13: pubmed publisher
	Mohamed O, El Bastawisy A, Allahlobi N, Abdellateif M, Zekri A, Shaarawy S, et al. The role of CD68+ macrophage in classical Hodgkin lymphoma patients from Egypt. Diagn Pathol. 2020;15:10 pubmed publisher
	Elsayed R, Kurago Z, Cutler C, Arce R, Gerber J, Celis E, et al. Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. FASEB J. 2020;34:2595-2608 pubmed publisher
	Izadi D, Layton T, Williams L, McCann F, Cabrita M, Espirito Santo A, et al. Identification of TNFR2 and IL-33 as therapeutic targets in localized fibrosis. Sci Adv. 2019;5:eaay0370 pubmed publisher
	Lan J, Sun L, Xu F, Liu L, Hu F, Song D, et al. M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer. Cancer Res. 2019;79:146-158 pubmed publisher
	Broeren M, Waterborg C, Wiegertjes R, Thurlings R, Koenders M, van Lent P, et al. A three-dimensional model to study human synovial pathology. ALTEX. 2019;36:18-28 pubmed publisher
	Yan J, Tie G, Wang S, Tutto A, DeMarco N, Khair L, et al. Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages. Nat Commun. 2018;9:33 pubmed publisher
	Douam F, Hrebikova G, Albrecht Y, Sellau J, Sharon Y, Ding Q, et al. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nat Commun. 2017;8:14781 pubmed publisher
	Tsai C, Lin Y, Huang C, Shih C, Tsai Y, Tsao N, et al. Thrombomodulin regulates monocye differentiation via PKC? and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421 pubmed publisher
	Broeren M, de Vries M, Bennink M, Arntz O, van Lent P, van der Kraan P, et al. Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane. Arthritis Res Ther. 2016;18:186 pubmed publisher
	Zhong Y, Yi C. MicroRNA-720 suppresses M2 macrophage polarization by targeting GATA3. Biosci Rep. 2016;36: pubmed publisher
	Mann E, Bernardo D, English N, Landy J, Al Hassi H, Peake S, et al. Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum. Gut. 2016;65:256-70 pubmed publisher
	He L, Marneros A. Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization. J Biol Chem. 2014;289:8019-28 pubmed publisher
	VanSaun M, Mendonsa A, Lee Gorden D. Hepatocellular proliferation correlates with inflammatory cell and cytokine changes in a murine model of nonalchoholic fatty liver disease. PLoS ONE. 2013;8:e73054 pubmed publisher
	Ikarashi M, Nakashima H, Kinoshita M, Sato A, Nakashima M, Miyazaki H, et al. Distinct development and functions of resident and recruited liver Kupffer cells/macrophages. J Leukoc Biol. 2013;94:1325-36 pubmed publisher
	Rowley J, Oler A, Tolley N, Hunter B, Low E, Nix D, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118:e101-11 pubmed publisher
	Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H, et al. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest. 2011;121:985-97 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD68 Monoclonal Antibody (eBioY1/82A (Y1/82A)), PE, eBioscience

Catalog # :

12-0689-42

Quantity :

100 Tests

Price :

US 342.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Human

Clone :

eBioY1/82A (Y1/82A)

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen

more info or order :

Invitrogen product webpage