CD62P (P-Selectin) Monoclonal Antibody (AK-4), PE, eBioscience | Invitrogen 12-0628-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD62P (P-Selectin) Monoclonal Antibody (AK-4), PE, eBioscience

catalog :

12-0628-42

quantity :

100 Tests

price :

US 290.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

AK-4

The same clone is also sold as:

BioLegend: 304941, 304908, 304920, 304938, 986402, 304924, 304906, 260364, 304927, 304929, 304931, 260362, 304943, 304928, 304935, 304932, 304910, 304905, 304947, 304945, 304918, 304914, 304951, 304904, 304942, 304903, 304916, 304919, 304936, 986404, 304937, 304933, 304922, 304944, 304949, 304925, 304926, 304930, 304921, 304902, 304948, 304940, 304939
OriGene: AM26020FC-N, AM26020AC-N, AM26020BT-N, AM26020PU-N, AM26020LE-N, AM26020RP-N
Santa Cruz Biotechnology: sc-19996, sc-19996 L
Exbio: 1F-667-T100, 1B-667-C100, T8-667-T100, 11-667-C025, 11-667-C100, 1A-667-T025, 1F-667-T025, 1A-667-T100, 1P-667-T100, 1P-667-T025, T8-667-T025, 1B-667-C025, 12-667-C100
BD Biosciences: 550888, 555523, 555522, 551345, 555524

reactivity :

human

application :

flow cytometry

citations: 7

Reference
Soo Kim B, Auerbach D, Sadhra H, Godwin M, Bhandari R, Ling F, et al. Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2021;41:390-400 pubmed publisher
Rolfes V, Ribeiro L, Hawwari I, Böttcher L, Rosero N, Maasewerd S, et al. Platelets Fuel the Inflammasome Activation of Innate Immune Cells. Cell Rep. 2020;31:107615 pubmed publisher
Zhang C, Srinivasan Y, Arlow D, Fung J, Palmer D, Zheng Y, et al. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012;492:387-92 pubmed publisher
Maione F, Cicala C, Liverani E, Mascolo N, Perretti M, D Acquisto F. IL-17A increases ADP-induced platelet aggregation. Biochem Biophys Res Commun. 2011;408:658-62 pubmed publisher
Kapp K, Maul J, Hostmann A, Mundt P, Preiss J, Wenzel A, et al. Modulation of systemic antigen-specific immune responses by oral antigen in humans. Eur J Immunol. 2010;40:3128-37 pubmed publisher
Chen W, Evans E, McEver R, Zhu C. Monitoring receptor-ligand interactions between surfaces by thermal fluctuations. Biophys J. 2008;94:694-701 pubmed
Sinauridze E, Kireev D, Popenko N, Pichugin A, Panteleev M, Krymskaya O, et al. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost. 2007;97:425-34 pubmed

product information

Product Type :

Antibody

Product Name :

CD62P (P-Selectin) Monoclonal Antibody (AK-4), PE, eBioscience

Catalog # :

12-0628-42

Quantity :

100 Tests

Price :

US 290.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.125 ug)/test

Species :

Human

Clone :

AK-4

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.125 ug)/test

Aliases :

CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; CD62P; CD62 homolog; FLJ45155; GMP140; GMP-140; GMRP; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; Grmp; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; PSELECT; P-selectin; P-selectin precursor; RP1-86F14.2; selectin P; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; Selp