CD49d (Integrin alpha 4) Monoclonal Antibody (9F10), PE, eBioscience™ | Invitrogen 12-0499-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD49d (Integrin alpha 4) Monoclonal Antibody (9F10), PE, eBioscience™

catalog :

12-0499-41

quantity :

25 Tests

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

9F10

reactivity :

human

application :

flow cytometry

citations: 13

Reference
Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett P, et al. Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. Stem Cells. 2019;37:1293-1306 pubmed publisher
Huang N, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, et al. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun. 2017;8:423 pubmed publisher
Swindle E, Brown J, Radinger M, Deleo F, Metcalfe D. Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus. Immunology. 2015;146:470-85 pubmed publisher
Bing T, Shangguan D, Wang Y. Facile Discovery of Cell-Surface Protein Targets of Cancer Cell Aptamers. Mol Cell Proteomics. 2015;14:2692-700 pubmed publisher
Ruiter B, Patil S, Shreffler W. Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells. Clin Exp Allergy. 2015;45:1214-25 pubmed publisher
Byrareddy S, Sidell N, Arthos J, Cicala C, Zhao C, Little D, et al. Species-specific differences in the expression and regulation of Î±4Î²7 integrin in various nonhuman primates. J Immunol. 2015;194:5968-79 pubmed publisher
Achour A, Baychelier F, Besson C, Arnoux A, Marty M, Hannoun L, et al. Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients. J Immunol. 2014;192:503-11 pubmed publisher
Spring F, Griffiths R, Mankelow T, Agnew C, Parsons S, Chasis J, et al. Tetraspanins CD81 and CD82 facilitate ?4?1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1. PLoS ONE. 2013;8:e62654 pubmed publisher
Indumathi S, Mishra R, Harikrishnan R, Rajkumar J, Kantawala N, Dhanasekaran M. Lineage depletion of stromal vascular fractions isolated from human adipose tissue: a novel approach towards cell enrichment technology. Cytotechnology. 2014;66:219-28 pubmed publisher
Lind A, Siersema P, Kusters J, van der Linden J, Knol E, Koenderman L. The immune cell composition in Barrett's metaplastic tissue resembles that in normal duodenal tissue. PLoS ONE. 2012;7:e33899 pubmed publisher
Dhanasekaran M, Indumathi S, Kanmani A, Poojitha R, Revathy K, Rajkumar J, et al. Surface antigenic profiling of stem cells from human omentum fat in comparison with subcutaneous fat and bone marrow. Cytotechnology. 2012;: pubmed
Betts G, Jones E, Junaid S, El Shanawany T, Scurr M, Mizen P, et al. Suppression of tumour-specific CD4? T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut. 2012;61:1163-71 pubmed publisher
Noborio Hatano K, Kikuchi J, Takatoku M, Shimizu R, Wada T, Ueda M, et al. Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma. Oncogene. 2009;28:231-42 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD49d (Integrin alpha 4) Monoclonal Antibody (9F10), PE, eBioscience™

Catalog # :

12-0499-41

Quantity :

25 Tests

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.125 µg)/test

Species :

Human

Clone :

9F10

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.125 µg)/test

Aliases :

269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; IA4; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITGA4; Itga4B; ITGA-IV; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha