CD48 Monoclonal Antibody (HM48-1), PE, eBioscience™ | Invitrogen 12-0481-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD48 Monoclonal Antibody (HM48-1), PE, eBioscience™

catalog :

12-0481-82

quantity :

100 µg

price :

US 309.00

clonality :

monoclonal

host :

hamsters

conjugate :

clone name :

HM48-1

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 36

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Xu Y, Swartz K, Siu K, Bhattacharyya M, Minella A. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene. 2014;33:3161-71 pubmed publisher
	Soukup A, Zheng Y, Mehta C, Wu J, Liu P, Cao M, et al. Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer. J Clin Invest. 2019;129:1180-1192 pubmed publisher
	Guo X, Chu L, Ke F, Mu L, Li Z, Cai J, et al. Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells. Oncotarget. 2017;8:108981-108988 pubmed publisher
	Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez N, Birbrair A, et al. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol. 2017;19:214-223 pubmed publisher
	Siu K, Xu Y, Swartz K, Bhattacharyya M, Gurbuxani S, Hua Y, et al. Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014;34:3244-58 pubmed publisher
	Gerhardt D, Pajcini K, D Altri T, Tu L, Jain R, Xu L, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev. 2014;28:576-93 pubmed publisher
	Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun K, et al. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014;211:209-15 pubmed publisher
	Nakata J, Nakano K, Okumura A, Mizutani Y, Kinoshita H, Iwai M, et al. In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity. Leukemia. 2014;28:1316-25 pubmed publisher
	Campaner S, Viale A, De Fazio S, Doni M, De Franco F, D Artista L, et al. A non-redundant function of cyclin E1 in hematopoietic stem cells. Cell Cycle. 2013;12:3663-72 pubmed publisher
	Luo B, Tseng C, Adams G, Lee A. Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells. Stem Cells Dev. 2013;22:3062-73 pubmed publisher
	Singh R, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, et al. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 2013;121:5158-66 pubmed publisher
	Sato T, Ikeda M, Yotsumoto S, Shimada Y, Higuchi T, Kobayashi H, et al. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood. 2013;121:3267-73 pubmed publisher
	Johnson K, Hsu A, Ryu M, Wang J, Gao X, Boyer M, et al. Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity. J Clin Invest. 2012;122:3692-704 pubmed publisher
	Gasparetto M, Sekulovic S, Zakaryan A, Imren S, Kent D, Humphries R, et al. Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status. Exp Hematol. 2012;40:857-66.e5 pubmed publisher
	Liu J, Mercher T, Scholl C, Brumme K, Gilliland D, Zhu N. A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells. Exp Hematol. 2012;40:487-98.e3 pubmed publisher
	Yuan H, Wang Z, Li L, Zhang H, Modi H, Horne D, et al. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood. 2012;119:1904-14 pubmed publisher
	Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed publisher
	Carbonneau C, Despars G, Rojas Sutterlin S, Fortin A, Le O, Hoang T, et al. Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. Blood. 2012;119:717-26 pubmed publisher
	Bungartz G, Land H, Scadden D, Emerson S. NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood. 2012;119:1380-9 pubmed publisher
	Kobayashi M, Srour E. Regulation of murine hematopoietic stem cell quiescence by Dmtf1. Blood. 2011;118:6562-71 pubmed publisher
	Li L, Bailey E, Greenblatt S, Huso D, Small D. Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice. Blood. 2011;118:4935-45 pubmed publisher
	Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Iwaki R, Uemura Y, et al. Low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells. Stem Cells. 2011;29:1783-91 pubmed publisher
	Glotzbach J, Januszyk M, Vial I, Wong V, Gelbard A, Kalisky T, et al. An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS ONE. 2011;6:e21211 pubmed publisher
	Prajeeth C, Haeberlein S, Sebald H, Schleicher U, Bogdan C. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun. 2011;79:2699-708 pubmed publisher
	Abbas H, Maccio D, Coskun S, Jackson J, Hazen A, SILLS T, et al. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010;7:606-17 pubmed publisher
	Wilhelm B, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, et al. RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity. Blood. 2011;117:e27-38 pubmed publisher
	Tzeng Y, Li H, Kang Y, Chen W, Cheng W, Lai D. Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood. 2011;117:429-39 pubmed publisher
	Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009;15:696-700 pubmed publisher
	Hartner J, Walkley C, Lu J, Orkin S. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol. 2009;10:109-15 pubmed publisher
	Levi B, Yilmaz O, Duester G, Morrison S. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood. 2009;113:1670-80 pubmed publisher
	Yang Q, Kardava L, St Leger A, Martincic K, Varnum Finney B, Bernstein I, et al. E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol. 2008;181:5885-94 pubmed
	Milne C, Corfe S, Paige C. Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis. J Immunol. 2008;180:2839-47 pubmed
	Sugano Y, Takeuchi M, Hirata A, Matsushita H, Kitamura T, Tanaka M, et al. Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker for long-term repopulating hematopoietic stem cells. Blood. 2008;111:1167-72 pubmed
	Taniguchi R, Guzior D, Kumar V. 2B4 inhibits NK-cell fratricide. Blood. 2007;110:2020-3 pubmed
	Desponts C, Hazen A, Paraiso K, Kerr W. SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation. Blood. 2006;107:4338-45 pubmed
	Priestley G, Scott L, Ulyanova T, Papayannopoulou T. Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity. Blood. 2006;107:2959-67 pubmed

product information

Product Type :

Antibody

Product Name :

CD48 Monoclonal Antibody (HM48-1), PE, eBioscience™

Catalog # :

12-0481-82

Quantity :

100 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 µg/test

Species :

Mouse

Clone :

HM48-1

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily that includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of the Ig family, thus mediating homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Further, signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases. CD48 is strongly expressed on lymphocytes and monocytes, weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. 2B4-CD48 interaction may be involved in the pathology of allergic airway diseases and provide a pharmacological target for the treatment of diseases such as allergic rhinitis and asthma.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test

Aliases :

AI449234; AW610730; BCM1; Bcm-1; BCM1 surface antigen; BLAST; BLAST1; BLAST-1; B-lymphocyte activation marker BLAST-1; Cd48; CD48 antigen; CD48 antigen (B-cell membrane protein); Cd48 molecule; CD48d; hCD48; HM48-1; leukocyte antigen MEM-102; mCD48; MEM-102; MRC OX-45 surface antigen; sCD 48; sCD48; Sgp-60; Signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF2; soluble CD 48; soluble CD48; TCT.1

more info or order :

Invitrogen product webpage