This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD46 Monoclonal Antibody (8E2), PE, eBioscience
catalog :
12-0469-42
quantity :
100 Tests
price :
US 290.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
8.00E+02
reactivity :
human
application :
flow cytometry
citations: 8
Reference
Gaykema L, van Nieuwland R, Dekkers M, van Essen M, Heidt S, Zaldumbide A, et al. Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids. Front Immunol. 2022;13:1058763 pubmed publisher
Mach N, Gao J, Schaffarczyk L, Janz S, Ehrke Schulz E, Dittmar T, et al. Spectrum-Wide Exploration of Human Adenoviruses for Breast Cancer Therapy. Cancers (Basel). 2020;12: pubmed publisher
Arbore G, West E, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun. 2018;9:4186 pubmed publisher
Petkova D, Verlhac P, Rozieres A, Baguet J, Clavière M, Kretz Remy C, et al. Distinct Contributions of Autophagy Receptors in Measles Virus Replication. Viruses. 2017;9: pubmed publisher
Tan D, Jensen K, Trotter M, Connelly J, Broad S, Watt F. Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development. 2013;140:1433-44 pubmed publisher
Grossman W, Verbsky J, Barchet W, Colonna M, Atkinson J, Ley T. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity. 2004;21:589-601 pubmed
Astier A, Trescol Biemont M, Azocar O, Lamouille B, Rabourdin Combe C. Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. J Immunol. 2000;164:6091-5 pubmed
Adams E, Brown M, Nunge M, Krych M, Atkinson J. Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J Immunol. 1991;147:3005-11 pubmed
product information
Product Type :
Antibody
Product Name :
CD46 Monoclonal Antibody (8E2), PE, eBioscience
Catalog # :
12-0469-42
Quantity :
100 Tests
Price :
US 290.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.5 ug)/test
Species :
Human
Clone :
8.00E+02
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.5 ug)/test
Aliases :
AHUS2; antigen identified by monoclonal antibody TRA-2-10; brain microvascular membrane cofactor; brain microvascular membrane cofactor protein CD46; Cd46; CD46 antigen, complement regulatory protein; CD46 complement regulatory protein; CD46 molecule; CD46 molecule, complement regulatory protein; CD46 splice variant; complement membrane cofactor protein; complement regulatory protein; Mcp; MCP; complement activation regulator; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); membrane cofactor protein variant 10; membrane cofactor protein variant 7; membrane cofactor protein variant 8; membrane cofactor protein variant 9; MGC26544; MIC10; soluble membrane cofactor protein variant 11; soluble membrane cofactor protein variant 12; soluble membrane cofactor protein variant 13; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA