CD45RB Monoclonal Antibody (C363.16A), PE, eBioscience™ | Invitrogen 12-0455-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45RB Monoclonal Antibody (C363.16A), PE, eBioscience™

catalog :

12-0455-82

quantity :

100 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

C363.16A

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 4	Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck M, et al. A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Oncotarget. 2016;7:51107-51123 pubmed publisher
flow cytometry; mouse; fig 3	Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed publisher
	Yu L, Yang F, Zhang F, Guo D, Li L, Wang X, et al. CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production. Cell Death Dis. 2018;9:905 pubmed publisher
	Sood S, Brownlie R, Garcia C, Cowan G, Salmond R, Sakaguchi S, et al. Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice. J Immunol. 2016;197:429-40 pubmed publisher
	Schippers A, Muschaweck M, Clahsen T, Tautorat S, Grieb L, Tenbrock K, et al. Î²7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon. Mucosal Immunol. 2016;9:527-38 pubmed publisher
	Yang B, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, et al. Foxp3(+) T cells expressing RORÎ³t represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2016;9:444-57 pubmed publisher
	Boland C, Li D, Shah S, Haberstock S, Dötsch V, Bernhard F, et al. Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination. Cell Mol Life Sci. 2014;71:4895-4910 pubmed publisher
	Mikami N, Sueda K, Ogitani Y, Otani I, Takatsuji M, Wada Y, et al. Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions. PLoS ONE. 2014;9:e86367 pubmed publisher
	Zanello G, Goethel A, Forster K, Geddes K, Philpott D, Croitoru K. Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis. PLoS ONE. 2013;8:e82623 pubmed publisher
	Xu M, Hou R, Sato Hayashizaki A, Man R, Zhu C, Wakabayashi C, et al. Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease. J Immunol. 2013;190:5436-45 pubmed publisher
	Lee S, Li X, Kim J, Lee J, Gonzalez Navajas J, Hong S, et al. Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Gastroenterology. 2012;143:145-54 pubmed publisher
	Zhen Y, Sun L, Liu H, Duan K, Zeng C, Zhang L, et al. Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes. Cell Mol Immunol. 2012;9:75-85 pubmed publisher
	Liu L, Duan L, Gong M, Dai H, Gong Q, Zheng F, et al. Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells. Cell Mol Immunol. 2011;8:31-40 pubmed publisher
	Kitamura K, Farber J, Kelsall B. CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype. J Immunol. 2010;185:3295-304 pubmed publisher
	Tan J, Quah B, Griffiths K, Periasamy P, Hey Y, O Neill H. Identification of a novel antigen cross-presenting cell type in spleen. J Cell Mol Med. 2011;15:1189-99 pubmed publisher
	Isomura I, Palmer S, Grumont R, Bunting K, Hoyne G, Wilkinson N, et al. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med. 2009;206:3001-14 pubmed publisher
	Sonawane S, Kim J, Lee M, Lee S, Duff P, Moore D, et al. GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation. 2009;88:1169-77 pubmed publisher
	Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger E, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol. 2009;182:259-73 pubmed
	Ciabattini A, Pettini E, Andersen P, Pozzi G, Medaglini D. Primary activation of antigen-specific naive CD4+ and CD8+ T cells following intranasal vaccination with recombinant bacteria. Infect Immun. 2008;76:5817-25 pubmed publisher
	Li X, McKinstry K, Swain S, Dalton D. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol. 2007;179:939-49 pubmed
	Witsch E, Cao H, Fukuyama H, Weigert M. Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. J Exp Med. 2006;203:1761-72 pubmed

product information

Product Type :

Antibody

Product Name :

CD45RB Monoclonal Antibody (C363.16A), PE, eBioscience™

Catalog # :

12-0455-82

Quantity :

100 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

C363.16A

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; Leukocyte common antigen; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen

more info or order :

Invitrogen product webpage