CD43 Monoclonal Antibody (eBioR2/60), PE, eBioscience | Invitrogen 12-0431-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD43 Monoclonal Antibody (eBioR2/60), PE, eBioscience

catalog :

12-0431-81

quantity :

50 ug

price :

US 132.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

eBioR2/60

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 30

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s3a	Svensson M, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody K, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020;6:eaba4353 pubmed publisher
flow cytometry; mouse; 1:200; loading ...; fig s12b	Grootjans J, Krupka N, Hosomi S, Matute J, Hanley T, Saveljeva S, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019;363:993-998 pubmed publisher
flow cytometry; mouse; loading ...; fig s3b	Tang C, Chang S, Paton A, Paton J, Gabrilovich D, Ploegh H, et al. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. J Cell Biol. 2018;217:1739-1755 pubmed publisher
flow cytometry; mouse; 1:100; loading ...; fig 1a	Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M. Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM. Int Immunol. 2017;29:431-438 pubmed publisher
flow cytometry; mouse	Mercadante A, Perobelli S, Alves A, Gonçalves Silva T, Mello W, Gomes Santos A, et al. Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance. J Immunol. 2014;192:1928-37 pubmed publisher
	Sayson S, Fan J, Ku C, Lo J, Chou S. DNAJA3 regulates B cell development and immune function. Biomed J. 2024;47:100628 pubmed publisher
	Azzoni E, Frontera V, Anselmi G, Rode C, James C, Deltcheva E, et al. The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition. Cell Rep. 2021;37:110103 pubmed publisher
	Sun A, Xu K, Liu H, Li H, Shi Y, Zhu X, et al. The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates. Sci Rep. 2020;10:4126 pubmed publisher
	Hidalgo San Jose L, Sunshine M, Dillingham C, Chua B, Krutá M, Hong Y, et al. Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. Cell Rep. 2020;30:69-80.e6 pubmed publisher
	Gal Oz S, Maier B, Yoshida H, Seddu K, Elbaz N, Czysz C, et al. ImmGen report: sexual dimorphism in the immune system transcriptome. Nat Commun. 2019;10:4295 pubmed publisher
	Ghezraoui H, Oliveira C, Becker J, Bilham K, Moralli D, Anzilotti C, et al. 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ. Nature. 2018;560:122-127 pubmed publisher
	Wang Y, Xiao M, Tao C, Chen J, Wang Z, Yang J, et al. Inactivation of mTORC1 Signaling in Osterix-expressing Cells Impairs B-cell Differentiation. J Bone Miner Res. 2017;: pubmed publisher
	Boulianne B, Robinson M, May P, Castellano L, Blighe K, Thomas J, et al. Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors. Cell Rep. 2017;18:1687-1698 pubmed publisher
	Cho W, Shin S, Kim S, Hong C, Choi C, Park W, et al. Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells. Radiat Oncol J. 2016;34:223-229 pubmed
	Souilhol C, Gonneau C, Lendínez J, Batsivari A, Rybtsov S, Wilson H, et al. Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. Nat Commun. 2016;7:10784 pubmed publisher
	Li Z, Scott M, Fan E, Li Y, Liu J, Xiao G, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23:1428-47 pubmed publisher
	Shrestha S, Noh J, Kim S, Ham H, Kim Y, Yun Y, et al. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype. Oncoimmunology. 2016;5:e1067744 pubmed
	Ying W, Tseng A, Chang R, Wang H, Lin Y, Kanameni S, et al. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep. 2016;6:20176 pubmed publisher
	Fiala G, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, et al. Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med. 2015;212:1693-708 pubmed publisher
	Liu X, Qian Y, Jung Y, Chen P. Isolation and immunomodulatory activity of bursal peptide, a novel bursal peptide from the chicken bursa of Fabricius. J Vet Sci. 2015;16:501-7 pubmed publisher
	Matsuda T, Yanase S, Takaoka A, Maruyama M. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Immun Ageing. 2015;12:1 pubmed publisher
	Lindner J, Kayo H, Hedlund S, Fukuda Y, Fukao T, Nielsen P. Cutting edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells. J Immunol. 2014;192:4483-6 pubmed publisher
	Vanoaica L, Richman L, Jaworski M, Darshan D, Luther S, Kühn L. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS ONE. 2014;9:e89270 pubmed publisher
	Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
	Gómez Herreros F, Romero Granados R, Zeng Z, Alvarez Quilón A, Quintero C, Ju L, et al. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet. 2013;9:e1003226 pubmed publisher
	Austin W, Armijo A, Campbell D, Singh A, Hsieh T, Nathanson D, et al. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012;209:2215-28 pubmed publisher
	Balkhi M, Willette Brown J, Zhu F, Chen Z, Liu S, Guttridge D, et al. IKK?-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012;119:5467-77 pubmed publisher
	Barao I, Alvarez M, Redelman D, Weiss J, Ortaldo J, Wiltrout R, et al. Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2011;17:1754-64 pubmed publisher
	Barao I, Alvarez M, Ames E, Orr M, Stefanski H, Blazar B, et al. Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC. Blood. 2011;117:7032-41 pubmed publisher
	Caddle L, Hasham M, Schott W, Shirley B, Mills K. Homologous recombination is necessary for normal lymphocyte development. Mol Cell Biol. 2008;28:2295-303 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD43 Monoclonal Antibody (eBioR2/60), PE, eBioscience

Catalog # :

12-0431-81

Quantity :

50 ug

Price :

US 132.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

eBioR2/60

Isotype :

IgM

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen

more info or order :

Invitrogen product webpage