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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD25 Monoclonal Antibody (OX39), PE, eBioscience
catalog :
12-0390-82
quantity :
100 ug
price :
US 126.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
OX39
reactivity :
rat
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 30
Published Application/Species/Sample/DilutionReference
  • flow cytometry; rat; loading ...; fig 5b
Jirsova Z, Heczkova M, Dankova H, Malinska H, Videnska P, Vespalcova H, et al. The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model. Biomed Res Int. 2019;2019:7084734 pubmed publisher
  • flow cytometry; rat; fig 5
Hu G, Yang S, Hu W, Wen Z, He D, Zeng L, et al. Effect of cold stress on immunity in rats. Exp Ther Med. 2016;11:33-42 pubmed
Yuan M, Qian X, Huang Y, Ma X, Duan F, Yang Y, et al. Th17 Activation and Th17/Treg Imbalance in Prolonged Anterior Intraocular Inflammation after Ocular Alkali Burn. Int J Mol Sci. 2022;23: pubmed publisher
Zou Q, Liu C, Hu N, Wang W, Wang H. miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg. Mol Biol Rep. 2022;49:2985-2998 pubmed publisher
Ge N, Peng J, Yu L, Huang S, Xu L, Su Y, et al. Orthodontic treatment induces Th17/Treg cells to regulate tooth movement in rats with periodontitis. Iran J Basic Med Sci. 2020;23:1315-1322 pubmed publisher
Xie D, Zhou G, Chen R, Qin X, Du J, Zhang Y, et al. Effect of Electroacupuncture at Zusanli (ST36) on Sepsis Induced by Cecal Ligation Puncture and Its Relevance to Spleen. Evid Based Complement Alternat Med. 2020;2020:1914031 pubmed publisher
Li H, Zhou Y, Zhao A, Guo L. Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis. Mediators Inflamm. 2020;2020:1320278 pubmed publisher
Du T, Yang C, Ge M, Liu Y, Zhang P, Li H, et al. M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response. Front Immunol. 2020;11:1603 pubmed publisher
Yin M, Shen Z, Yang L, Zheng W, Song H. Protective effects of CXCR3/HO‑1 gene‑modified BMMSCs on damaged intestinal epithelial cells: Role of the p38‑MAPK signaling pathway. Int J Mol Med. 2019;43:2086-2102 pubmed publisher
Jiao Y, Tan S, Xiong J. Proteomic changes of CD4+/CD25+/forkhead box p3+ regulatory T cells in a 30-day rat model of sepsis survival. Exp Ther Med. 2017;14:5619-5628 pubmed publisher
Zhang Y, Meng Q, Zhang Y, Chen X, Wang Y. Adipose-derived mesenchymal stem cells suppress of acute rejection in small bowel transplantation. Saudi J Gastroenterol. 2017;23:323-329 pubmed publisher
Xie L, Zhong X, Liu D, Liu L, Xia Z. The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model. BMC Complement Altern Med. 2017;17:511 pubmed publisher
Li Y, Li H, Cao Y, Wu F, Ma W, Wang Y, et al. Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance. Mol Med Rep. 2017;16:8137-8145 pubmed publisher
Oliveira L, Correia A, Cristina Costa A, Guerra Gomes S, Ferreirinha F, Magalhães Cardoso M, et al. Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis. Mediators Inflamm. 2015;2015:460610 pubmed publisher
Wu Y, Ye Q, Eytan D, Liu L, Rosario B, Hitchens T, et al. Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation. Circ Cardiovasc Imaging. 2013;6:965-73 pubmed publisher
Wang G, Zhang Q, Yang Y, Chen W, Liu W, Jiang N, et al. Rapamycin combined with allogenic immature dendritic cells selectively expands CD4+CD25+Foxp3+ regulatory T cells in rats. Hepatobiliary Pancreat Dis Int. 2012;11:203-8 pubmed
Kang J, de Brito Bezerra B, Pacios S, Andriankaja O, Li Y, TSIAGBE V, et al. Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis. Infect Immun. 2012;80:2247-56 pubmed publisher
Bezerra B, Andriankaja O, Kang J, Pacios S, Bae H, Li Y, et al. A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium. J Clin Periodontol. 2012;39:333-41 pubmed publisher
Schu S, Nosov M, O Flynn L, Shaw G, Treacy O, Barry F, et al. Immunogenicity of allogeneic mesenchymal stem cells. J Cell Mol Med. 2012;16:2094-103 pubmed publisher
Wang G, Yang Y, Li H, Zhang J, Li M, Zhang Q, et al. Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4(+) CD25(+) Foxp3(+) regulatory T cell expansion. Hepatol Res. 2012;42:192-202 pubmed publisher
Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung Y, Gera L, et al. Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res. 2011;109:867-79 pubmed publisher
Wu C, Xia Y, Wang P, Lu L, Zhang F. Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production. Int Immunopharmacol. 2011;11:1564-72 pubmed publisher
Takabatake Y, Li X, Mizui M, Miyasato K, Matsui I, Kawada N, et al. A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats. Mol Med. 2011;17:686-96 pubmed publisher
Dominguez M, Lorenzo N, Barbera A, Darrasse Jèze G, Hernández M, Torres A, et al. An altered peptide ligand corresponding to a novel epitope from heat-shock protein 60 induces regulatory T cells and suppresses pathogenic response in an animal model of adjuvant-induced arthritis. Autoimmunity. 2011;44:471-82 pubmed publisher
Visser J, Hillebrands J, Walther Boer M, Bos N, Rozing J. Prevention of diabetes by a hydrolysed casein-based diet in diabetes-prone BioBreeding rats does not involve restoration of the defective natural regulatory T cell function. Diabetologia. 2009;52:1445-7 pubmed publisher
Brugman S, Visser J, Hillebrands J, Bos N, Rozing J. Prolonged exclusive breastfeeding reduces autoimmune diabetes incidence and increases regulatory T-cell frequency in bio-breeding diabetes-prone rats. Diabetes Metab Res Rev. 2009;25:380-7 pubmed publisher
Tischner D, Weishaupt A, van den Brandt J, Müller N, Beyersdorf N, Ip C, et al. Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis. Brain. 2006;129:2635-47 pubmed
Beyersdorf N, Balbach K, Hunig T, Kerkau T. Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation. Immunology. 2006;119:441-50 pubmed
Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka K, Lin C, et al. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med. 2005;202:445-55 pubmed
Paterson D, Jefferies W, Green J, Brandon M, Corthesy P, Puklavec M, et al. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol. 1987;24:1281-90 pubmed
product information
Product Type :
Antibody
Product Name :
CD25 Monoclonal Antibody (OX39), PE, eBioscience
Catalog # :
12-0390-82
Quantity :
100 ug
Price :
US 126.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Rat
Applications :
Flow Cytometry: 0.125 ug/test
Species :
Rat
Clone :
OX39
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 ug/test
Aliases :
ADA; ADA1; Adenosine aminohydrolase; adenosine deaminase; CD25; CD25 antigen; cytokine receptor; IDDM10; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; il-2 receptor alpha; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL2 receptor subunit alpha; IL-2 receptor subunit alpha; IL2R; IL-2R alpha; IL-2R alpha chain; IL2R subunit alpha; IL-2R subunit alpha; Il2ra; IL-2RA; IL-2-RA; IL2-RA; Il2ra antibody; IL2RAC; IMD41; interleukin 2 receptor; interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor alpha subunit; interleukin-2 receptor beta chain; Interleukin2 receptor subunit alpha; interleukin-2 receptor subunit alpha; Ly-43; p55; p55 chain; sIL 2R; soluble IL 2 receptor; TAC antigen; TCGFR
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA