SIGLEC H Monoclonal Antibody (eBio440c), PE, eBioscience | Invitrogen 12-0333-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SIGLEC H Monoclonal Antibody (eBio440c), PE, eBioscience

catalog :

12-0333-82

quantity :

100 ug

price :

US 395.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

eBio440c

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 1d	Chopin M, Lun A, Zhan Y, Schreuder J, Coughlan H, D Amico A, et al. Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT. Immunity. 2019;50:77-90.e5 pubmed publisher
flow cytometry; mouse	Sullivan B, Teijaro J, de la Torre J, Oldstone M. Early virus-host interactions dictate the course of a persistent infection. PLoS Pathog. 2015;11:e1004588 pubmed publisher
	Groh J, Abdelwahab T, Kattimani Y, H xf6 rner M, Loserth S, Gudi V, et al. Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nat Commun. 2023;14:6911 pubmed publisher
	Xu H, Li Z, Kuo C, G xf6 tz K, Look T, de Toledo M, et al. A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation. elife. 2023;12: pubmed publisher
	Anderson D, Ou F, Kim S, Murphy T, Murphy K. Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8. J Exp Med. 2022;219: pubmed publisher
	Jamali A, Hu K, Sendra V, Blanco T, Lopez M, Ortiz G, et al. Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis. Cell Rep. 2020;32:108099 pubmed publisher
	Camell C, Günther P, Lee A, Goldberg E, Spadaro O, Youm Y, et al. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019;30:1024-1039.e6 pubmed publisher
	Zwick M, Ulas T, Cho Y, Ried C, Grosse L, Simon C, et al. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells. Front Immunol. 2019;10:222 pubmed publisher
	Cousin C, Oberkampf M, Félix T, Rosenbaum P, Weil R, Fabrega S, et al. Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses. Cell Rep. 2019;26:1242-1257.e7 pubmed publisher
	Hensel J, Khattar V, Ashton R, Ponnazhagan S. Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations. Lab Invest. 2019;99:93-106 pubmed publisher
	Millet A, Martin K, Bonnefoy F, Saas P, Mocek J, Alkan M, et al. Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis. J Clin Invest. 2015;125:4107-21 pubmed publisher
	Riepsaame J, van Oudenaren A, den Broeder B, van Ijcken W, Pothof J, Leenen P. MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells. Front Immunol. 2013;4:353 pubmed publisher
	Liu H, Ramachandran I, Gabrilovich D. Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor. Immunol Cell Biol. 2014;92:200-3 pubmed publisher
	Maina V, Marrella V, Mantero S, Cassani B, Fontana E, Anselmo A, et al. Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol. 2013;94:1221-30 pubmed publisher
	Baccarella A, Fontana M, Chen E, Kim C. Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun. 2013;81:4431-42 pubmed publisher
	Oderup C, Lajevic M, Butcher E. Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. J Immunol. 2013;190:6126-34 pubmed publisher
	Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, et al. Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal Immunol. 2013;6:847-56 pubmed publisher
	Kim C, Nelson C, Wilson E, Hou B, DeFranco A, Derisi J. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS ONE. 2012;7:e48126 pubmed publisher
	Crother T, Ma J, Jupelli M, Chiba N, Chen S, Slepenkin A, et al. Plasmacytoid dendritic cells play a role for effective innate immune responses during Chlamydia pneumoniae infection in mice. PLoS ONE. 2012;7:e48655 pubmed publisher
	Ho A, Prabhu N, Betts R, Ge M, Dai X, Hutchinson P, et al. Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells. J Immunol. 2011;187:6011-21 pubmed publisher
	Davidson S, Kaiko G, Loh Z, Lalwani A, Zhang V, Spann K, et al. Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway. J Immunol. 2011;186:5938-48 pubmed publisher
	Bao Y, Han Y, Chen Z, Xu S, Cao X. IFN-?-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells. Eur J Immunol. 2011;41:657-68 pubmed publisher
	Charles E, Joshi S, Ash J, Fox B, Farris A, Bzik D, et al. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010;78:3484-92 pubmed publisher
	Hermesh T, Moltedo B, Moran T, LOPEZ C. Antiviral instruction of bone marrow leukocytes during respiratory viral infections. Cell Host Microbe. 2010;7:343-53 pubmed publisher
	Provoost S, Maes T, Willart M, Joos G, Lambrecht B, Tournoy K. Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells. J Immunol. 2010;184:426-32 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SIGLEC H Monoclonal Antibody (eBio440c), PE, eBioscience

Catalog # :

12-0333-82

Quantity :

100 ug

Price :

US 395.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 ug/test

Species :

Mouse

Clone :

eBio440c

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 ug/test

Aliases :

6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein

more info or order :

Invitrogen product webpage