product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD25 Monoclonal Antibody (BC96), PE, eBioscience
catalog :
12-0259-42
quantity :
100 Tests
price :
US 269.00
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
BC96
reactivity :
human, mouse
application :
flow cytometry
more info or order :
citations: 128
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, et al. T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer. J Immunother Cancer. 2022;10: pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...
Li N, Torres M, Spetz M, Wang R, Peng L, Tian M, et al. CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Rep Med. 2021;2:100297 pubmed publisher
  • flow cytometry; human; loading ...; fig s1c
Zhang Q, He Y, Luo N, Patel S, Han Y, Gao R, et al. Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma. Cell. 2019;179:829-845.e20 pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Lim S, Kim J, Jeon S, Shin M, Kwon J, Kim T, et al. Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients. Front Immunol. 2019;10:496 pubmed publisher
  • flow cytometry; human; loading ...; tbl 1
Zheng C, Zheng L, Yoo J, Guo H, Zhang Y, Guo X, et al. Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. Cell. 2017;169:1342-1356.e16 pubmed publisher
  • flow cytometry; human; fig 5
Su S, Hu B, Shao J, Shen B, Du J, Du Y, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep. 2016;6:20070 pubmed publisher
  • flow cytometry; human; fig 1
Ziblat A, Domaica C, Spallanzani R, Iraolagoitia X, Rossi L, Avila D, et al. IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness. Eur J Immunol. 2015;45:192-202 pubmed publisher
Schmitz C, Alt C, Azares A, Pearce D, Facile T, Furia J, et al. The Composition of Adipose-Derived Regenerative Cells Isolated from Lipoaspirate Using a Point of Care System Does Not Depend on the Subject's Individual Age, Sex, Body Mass Index and Ethnicity. Cells. 2022;12: pubmed publisher
Hu Y, Chen Y, Chen Z, Zhang X, Guo C, Yu Z, et al. Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients. Front Cell Dev Biol. 2021;9:799560 pubmed publisher
Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, et al. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. Gastroenterology. 2021;161:575-591.e16 pubmed publisher
Yu C, Littleton S, Giroux N, Mathew R, Ding S, Kalnitsky J, et al. Mucosal-associated invariant T cell responses differ by sex in COVID-19. Med (N Y). 2021;2:755-772.e5 pubmed publisher
Tewari R, Shayahati B, Fan Y, Akimzhanov A. T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. J Biol Chem. 2021;:100311 pubmed publisher
Zu J, Yao L, Song Y, Cui Y, Guan M, Chen R, et al. Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa. Front Immunol. 2020;11:570888 pubmed publisher
Henderson L, Hoyt K, Lee P, Rao D, Jonsson A, Nguyen J, et al. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020;5: pubmed publisher
Agarwal S, Kraus Z, Dement Brown J, Alabi O, Starost K, Tolnay M. Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA. Cell Rep. 2020;30:1292-1299.e3 pubmed publisher
Zhou Z, Chen H, Xie R, Wang H, Li S, Xu Q, et al. Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer. Mol Oncol. 2019;13:873-893 pubmed publisher
Tomic S, Ilic N, Kokol V, Gruden Movsesijan A, Mihajlović D, Bekić M, et al. Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells. Int J Nanomedicine. 2018;13:6941-6960 pubmed publisher
Guo X, Jiang H, Shi B, Zhou M, Zhang H, Shi Z, et al. Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma. Front Pharmacol. 2018;9:1118 pubmed publisher
Ding J, Zhou T, Zheng X, Wang X, Tong X, Luo C, et al. The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis. Acta Cardiol Sin. 2018;34:399-408 pubmed publisher
Whiteoak S, Claridge A, Balendran C, Harris R, Gwiggner M, Bondanese V, et al. MicroRNA-31 Targets Thymic Stromal Lymphopoietin in Mucosal Infiltrated CD4+ T Cells: A Role in Achieving Mucosal Healing in Ulcerative Colitis?. Inflamm Bowel Dis. 2018;24:2377-2385 pubmed publisher
Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, et al. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. J Clin Invest. 2018;128:2551-2568 pubmed publisher
Albert B, Niu A, Ramani R, Marshall G, Wender P, Williams R, et al. Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation. Sci Rep. 2017;7:7456 pubmed publisher
Su S, Zou Z, Chen F, Ding N, Du J, Shao J, et al. CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology. 2017;6:e1249558 pubmed publisher
Blewett M, Xie J, Zaro B, Backus K, Altman A, Teijaro J, et al. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci Signal. 2016;9:rs10 pubmed publisher
Zhao J, Ma J, Zhang X, Li Q, Yang X. Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Exp Ther Med. 2016;11:2300-2304 pubmed
Ghosh S, Taylor A, Chin M, Huang H, Conery A, Mertz J, et al. Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition. J Biol Chem. 2016;291:13014-27 pubmed publisher
Macdonald K, Hoeppli R, Huang Q, Gillies J, Luciani D, Orban P, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest. 2016;126:1413-24 pubmed publisher
Younis R, Han K, Webb T. Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. J Immunol. 2016;196:1419-29 pubmed publisher
Pedroza Gonzalez A, Zhou G, Singh S, Boor P, Pan Q, Grunhagen D, et al. GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo. Oncoimmunology. 2015;4:e1051297 pubmed
Teteloshvili N, Kluiver J, van der Geest K, van der Lei R, Jellema P, Pawelec G, et al. Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing. PLoS ONE. 2015;10:e0137556 pubmed publisher
Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, et al. Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors. J Immunol. 2015;195:2141-8 pubmed publisher
Lipson E, Sharfman W, Chen S, McMiller T, Pritchard T, Salas J, et al. Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting. J Transl Med. 2015;13:214 pubmed publisher
Servais S, Menten Dedoyart C, Beguin Y, Seidel L, Gothot A, Daulne C, et al. Impact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation. PLoS ONE. 2015;10:e0130026 pubmed publisher
Burns J, Touma R, Song Y, Padilla R, Tremoulet A, Sidney J, et al. Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease. Autoimmunity. 2015;48:181-8 pubmed publisher
Sotiropoulos C, Theodorou G, Repa C, Marinakis T, Verigou E, Solomou E, et al. Severe impairment of regulatory T-cells and Th1-lymphocyte polarization in patients with Gaucher disease. JIMD Rep. 2015;18:107-15 pubmed publisher
Gründemann C, Lengen K, Sauer B, Garcia Käufer M, Zehl M, Huber R. Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells. BMC Complement Altern Med. 2014;14:283 pubmed publisher
Tang Y, Xu X, Guo S, Zhang C, Tang Y, Tian Y, et al. An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma. PLoS ONE. 2014;9:e91551 pubmed publisher
Ivanova I, Seledtsova G, Mamaev S, Shishkov A, Seledtsov V. Immune responses induced by T-cell vaccination in patients with rheumatoid arthritis. Hum Vaccin Immunother. 2014;10:1221-7 pubmed publisher
Legat A, Speiser D, Pircher H, Zehn D, Fuertes Marraco S. Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8?T Cells. Front Immunol. 2013;4:455 pubmed publisher
Renand A, Milpied P, Rossignol J, Bruneau J, Lemonnier F, Dussiot M, et al. Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs. PLoS ONE. 2013;8:e85589 pubmed publisher
Tittarelli A, Mendoza Naranjo A, Farías M, Guerrero I, Ihara F, Wennerberg E, et al. Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity. J Immunol. 2014;192:1313-9 pubmed publisher
Arandi N, Mirshafiey A, Jeddi Tehrani M, Shaghaghi M, Sadeghi B, Abolhassani H, et al. Alteration in frequency and function of CD4?CD25?FOXP3? regulatory T cells in patients with immune thrombocytopenic purpura. Iran J Allergy Asthma Immunol. 2014;13:85-92 pubmed
Gui T, Chen C, Zhang Z, Tang W, Qian R, Ma X, et al. The disturbance of TH17-Treg cell balance in adenomyosis. Fertil Steril. 2014;101:506-14 pubmed publisher
Kumar S, Naqvi R, Ali R, Rani R, Khanna N, Rao D. FoxP3 provides competitive fitness to CD4?CD25? T cells in leprosy patients via transcriptional regulation. Eur J Immunol. 2014;44:431-9 pubmed publisher
Sutavani R, Bradley R, Ramage J, Jackson A, Durrant L, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol. 2013;191:5895-903 pubmed publisher
Ji N, Somanaboeina A, Dixit A, Kawamura K, Hayward N, Self C, et al. Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis. J Immunol. 2013;191:5074-84 pubmed publisher
Fang L, Lowther D, Meizlish M, Anderson R, Bruce J, Devine L, et al. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro Oncol. 2013;15:1479-90 pubmed publisher
Kumar S, Naqvi R, Ali R, Rani R, Khanna N, Rao D. CD4+CD25+ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy. Mol Immunol. 2013;56:513-20 pubmed publisher
Burns J, Song Y, Bujold M, Shimizu C, Kanegaye J, Tremoulet A, et al. Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin. Clin Exp Immunol. 2013;174:337-44 pubmed publisher
Matsumoto T, Hasegawa H, Onishi S, Ishizaki J, Suemori K, Yasukawa M. Protein kinase C inhibitor generates stable human tolerogenic dendritic cells. J Immunol. 2013;191:2247-57 pubmed publisher
Liu X, Gao N, Li M, Xu D, Hou Y, Wang Q, et al. Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS ONE. 2013;8:e64531 pubmed publisher
Jenks J, Seki S, Kanai T, Huang J, Morgan A, Scalco R, et al. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013;148:227-36 pubmed publisher
Hannon M, Lechanteur C, Lucas S, Somja J, Seidel L, Belle L, et al. Infusion of clinical-grade enriched regulatory T cells delays experimental xenogeneic graft-versus-host disease. Transfusion. 2014;54:353-63 pubmed publisher
Zhai R, Jiang A, Wang H, Ma L, Ren X, Jiang J, et al. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells. Virology. 2013;442:163-72 pubmed publisher
Arandi N, Mirshafiey A, Jeddi Tehrani M, Abolhassani H, Sadeghi B, Mirminachi B, et al. Evaluation of CD4+CD25+FOXP3+ regulatory T cells function in patients with common variable immunodeficiency. Cell Immunol. 2013;281:129-33 pubmed publisher
Pihl M, Akerman L, Axelsson S, Chéramy M, Hjorth M, Mallone R, et al. Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes. Clin Exp Immunol. 2013;172:394-402 pubmed publisher
Lim S, Kim T, Lee J, Sonn C, Kim K, Kim J, et al. Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res. 2013;73:2598-607 pubmed publisher
Hedges J, Kimmel E, Snyder D, Jerome M, Jutila M. Solute carrier 11A1 is expressed by innate lymphocytes and augments their activation. J Immunol. 2013;190:4263-73 pubmed publisher
Miyatake Y, Oliveira A, Jarboui M, Ota S, Tomaru U, Teshima T, et al. Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. Am J Pathol. 2013;182:1832-42 pubmed publisher
Arandi N, Mirshafiey A, Abolhassani H, Jeddi Tehrani M, Edalat R, Sadeghi B, et al. Frequency and expression of inhibitory markers of CD4(+) CD25(+) FOXP3(+) regulatory T cells in patients with common variable immunodeficiency. Scand J Immunol. 2013;77:405-12 pubmed publisher
Bruck F, Belle L, Lechanteur C, de Leval L, Hannon M, Dubois S, et al. Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease. Cytotherapy. 2013;15:267-79 pubmed publisher
Tatura R, Zeschnigk M, Adamzik M, Probst Kepper M, Buer J, Kehrmann J. Quantification of regulatory T cells in septic patients by real-time PCR-based methylation assay and flow cytometry. PLoS ONE. 2012;7:e49962 pubmed publisher
Terme M, Pernot S, Marcheteau E, Sandoval F, Benhamouda N, Colussi O, et al. VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. Cancer Res. 2013;73:539-49 pubmed publisher
Huang Z, Yang B, Shi Y, Cai B, Li Y, Feng W, et al. Anti-TNF-? therapy improves Treg and suppresses Teff in patients with rheumatoid arthritis. Cell Immunol. 2012;279:25-9 pubmed publisher
Soheili H, Abolhassani H, Arandi N, Khazaei H, Shahinpour S, Hirbod Mobarakeh A, et al. Evaluation of natural regulatory T cells in subjects with selective IgA deficiency: from senior idea to novel opportunities. Int Arch Allergy Immunol. 2013;160:208-14 pubmed publisher
Xiao J, Zhu F, Liu X, Xiong J. Th1/Th2/Th17/Treg expression in cultured PBMCs with antiphospholipid antibodies. Mol Med Rep. 2012;6:1035-9 pubmed publisher
Trabanelli S, Ocadlikova D, Gulinelli S, Curti A, Salvestrini V, Vieira R, et al. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol. 2012;189:1303-10 pubmed publisher
Winnall W, Sexton A, Alcantara S, Roath S, De Rose R, Kent S. Characterisation of simian immunodeficiency virus-infected cells in pigtail macaques. Virology. 2012;428:11-20 pubmed publisher
Horowitz A, Hafalla J, King E, Lusingu J, Dekker D, Leach A, et al. Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine. J Immunol. 2012;188:5054-62 pubmed publisher
Wang L, Kang N, Zhou J, Guo Y, Zhang X, Cui L, et al. Downregulation of CD94/NKG2A inhibitory receptor on decreased ?? T cells in patients with systemic lupus erythematosus. Scand J Immunol. 2012;76:62-9 pubmed publisher
Tremoulet A, Pancoast P, Franco A, Bujold M, Shimizu C, Onouchi Y, et al. Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2012;161:506-512.e1 pubmed publisher
Müller A, Jun E, Conlon H, Sadiq S. Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis. BMC Neurosci. 2012;13:30 pubmed publisher
Liu L, Deng S, Teng L, Fu Q, Wang C, He X. Absolute of CD4(+)CD25(+)FOXP3(+) regulatory T-cell count rather than its ratio in peripheral blood is related to long-term survival of renal allografts. Transplant Proc. 2012;44:284-6 pubmed publisher
de Kivit S, Saeland E, Kraneveld A, van de Kant H, Schouten B, van Esch B, et al. Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Allergy. 2012;67:343-52 pubmed publisher
Yarkoni S, Prigozhina T, Slavin S, Askenasy N. IL-2-targeted therapy ameliorates the severity of graft-versus-host disease: ex vivo selective depletion of host-reactive T cells and in vivo therapy. Biol Blood Marrow Transplant. 2012;18:523-35 pubmed publisher
Legorreta Haquet M, Chavez Rueda K, Montoya Díaz E, Arriaga Pizano L, Silva Garcia R, Chavez Sanchez L, et al. Prolactin down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans. J Mol Endocrinol. 2012;48:77-85 pubmed publisher
Rossi L, Avila D, Spallanzani R, Ziblat A, Fuertes M, Lapyckyj L, et al. Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. J Leukoc Biol. 2012;91:321-31 pubmed publisher
Brindley S, Lanham A, Karrer F, Tucker R, Fontenot A, Mack C. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012;55:1130-8 pubmed publisher
Rudnicka K, Włodarczyk M, Moran A, Rechcinski T, Miszczyk E, Matusiak A, et al. Helicobacter pylori antigens as potential modulators of lymphocytes' cytotoxic activity. Microbiol Immunol. 2012;56:62-75 pubmed publisher
Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, et al. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl). 2012;90:175-86 pubmed publisher
Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, et al. IL-1? and TNF?-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int Immunol. 2011;23:701-12 pubmed publisher
Li Y, Shi Y, Huang Z, Bai Y, Niu Q, Cai B, et al. CNI induced Th17/Treg imbalance and susceptibility to renal dysfunction in renal transplantation. Int Immunopharmacol. 2011;11:2033-8 pubmed publisher
Landrigan A, Wong M, Utz P. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-43 pubmed publisher
Niu Q, Cai B, Huang Z, Shi Y, Wang L. Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatol Int. 2012;32:2731-6 pubmed publisher
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Plet A, et al. Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice. Eur J Immunol. 2011;41:2883-93 pubmed publisher
Kalache S, Dinavahi R, Pinney S, Mehrotra A, Cunningham M, Heeger P. Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients. J Immunol. 2011;187:1023-30 pubmed publisher
Li J, Chen Q, Mo H, Zhang Y, Huang Z, Zeng Y. Immunophenotyping at the time of diagnosis distinguishes two groups of nasopharyngeal carcinoma patients: implications for adoptive immunotherapy. Int J Biol Sci. 2011;7:607-17 pubmed
Kim S, Han S, Withers D, Gaspal F, Bae J, Baik S, et al. CD117? CD3? CD56? OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues. Eur J Immunol. 2011;41:1563-72 pubmed publisher
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Mention J, et al. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A. 2011;108:6217-22 pubmed publisher
Coffelt S, Chen Y, Muthana M, Welford A, Tal A, Scholz A, et al. Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. J Immunol. 2011;186:4183-90 pubmed publisher
He X, Smeets R, Koenen H, Vink P, Wagenaars J, Boots A, et al. Mycophenolic acid-mediated suppression of human CD4+ T cells: more than mere guanine nucleotide deprivation. Am J Transplant. 2011;11:439-49 pubmed publisher
Araya N, Takahashi K, Sato T, Nakamura T, Sawa C, Hasegawa D, et al. Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease. Antivir Ther. 2011;16:89-98 pubmed publisher
Mackroth M, Malhotra I, Mungai P, Koech D, Muchiri E, King C. Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens. J Immunol. 2011;186:2780-91 pubmed publisher
Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, et al. Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Blood. 2011;117:2839-46 pubmed publisher
Bjoern J, Brimnes M, Andersen M, thor Straten P, Svane I. Changes in peripheral blood level of regulatory T cells in patients with malignant melanoma during treatment with dendritic cell vaccination and low-dose IL-2. Scand J Immunol. 2011;73:222-33 pubmed publisher
Cubillos Ruiz J, Martinez D, Scarlett U, Rutkowski M, Nesbeth Y, Camposeco Jacobs A, et al. CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. Oncotarget. 2010;1:329-38 pubmed
Rogers N, Kireta S, Coates P. Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol. 2010;162:460-73 pubmed publisher
Takao S, Ishikawa T, Yamashita K, Uchiyama T. The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells. J Immunol. 2010;185:6031-40 pubmed publisher
Marwaha A, Crome S, Panagiotopoulos C, Berg K, Qin H, Ouyang Q, et al. Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol. 2010;185:3814-8 pubmed publisher
De Latour R, Visconte V, Takaku T, Wu C, Erie A, Sarcon A, et al. Th17 immune responses contribute to the pathophysiology of aplastic anemia. Blood. 2010;116:4175-84 pubmed publisher
Wang D, Zhang H, Liang J, Gu Z, Zhou Q, Fan X, et al. CD4+ CD25+ but not CD4+ Foxp3+ T cells as a regulatory subset in primary biliary cirrhosis. Cell Mol Immunol. 2010;7:485-90 pubmed publisher
Antonelli L, Mahnke Y, Hodge J, Porter B, Barber D, DerSimonian R, et al. Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood. 2010;116:3818-27 pubmed publisher
Gu Z, Akiyama K, Ma X, Zhang H, Feng X, Yao G, et al. Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus. 2010;19:1502-14 pubmed publisher
Martin J, Perry J, Jakhete N, Wang X, Bielekova B. An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol. 2010;185:1311-20 pubmed publisher
Ratajczak P, Janin A, Peffault De Latour R, Leboeuf C, Desveaux A, Keyvanfar K, et al. Th17/Treg ratio in human graft-versus-host disease. Blood. 2010;116:1165-71 pubmed publisher
Denecke C, Bedi D, Ge X, Kim I, Jurisch A, Weiland A, et al. Prolonged graft survival in older recipient mice is determined by impaired effector T-cell but intact regulatory T-cell responses. PLoS ONE. 2010;5:e9232 pubmed publisher
Flanagan K, Halliday A, Burl S, Landgraf K, Jagne Y, Noho Konteh F, et al. The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth. Eur J Immunol. 2010;40:1062-72 pubmed publisher
Jury E, Flores Borja F, Kalsi H, Lazarus M, Isenberg D, Mauri C, et al. Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus. Eur J Immunol. 2010;40:569-78 pubmed publisher
McGee H, Stallworth A, Agrawal T, Shao Z, Lorence L, Agrawal D. Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice. Am J Respir Cell Mol Biol. 2010;43:520-9 pubmed publisher
Zahorchak A, Raimondi G, Thomson A. Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells. Transplantation. 2009;88:1057-64 pubmed publisher
Sagiv Y, Kaminitz A, Lorberboum Galski H, Askenasy N, Yarkoni S. A fusion protein composed of IL-2 and caspase-3 ameliorates the outcome of experimental inflammatory colitis. Ann N Y Acad Sci. 2009;1173:791-7 pubmed publisher
Iikuni N, Lourenço E, Hahn B, La Cava A. Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus. J Immunol. 2009;183:1518-22 pubmed publisher
Kang N, Tang L, Li X, Wu D, Li W, Chen X, et al. Identification and characterization of Foxp3(+) gammadelta T cells in mouse and human. Immunol Lett. 2009;125:105-13 pubmed publisher
Mor A, Kloog Y, Keren G, George J. Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. Eur J Pharmacol. 2009;616:301-5 pubmed publisher
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
McGee H, Edwan J, Agrawal D. Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice. Am J Respir Cell Mol Biol. 2010;42:331-40 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD25 Monoclonal Antibody (BC96), PE, eBioscience
Catalog # :
12-0259-42
Quantity :
100 Tests
Price :
US 269.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.125 µg)/test
Species :
Human
Clone :
BC96
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.125 µg)/test
Aliases :
ADA; ADA1; Adenosine aminohydrolase; adenosine deaminase; CD25; CD25 antigen; cytokine receptor; IDDM10; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; il-2 receptor alpha; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL2 receptor subunit alpha; IL-2 receptor subunit alpha; IL2R; IL-2R alpha; IL-2R alpha chain; IL2R subunit alpha; IL-2R subunit alpha; Il2ra; IL-2RA; IL-2-RA; IL2-RA; Il2ra antibody; IL2RAC; IMD41; interleukin 2 receptor; interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor alpha subunit; interleukin-2 receptor beta chain; Interleukin2 receptor subunit alpha; interleukin-2 receptor subunit alpha; Ly-43; p55; p55 chain; sIL 2R; soluble IL 2 receptor; TAC antigen; TCGFR
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA