CD21 Monoclonal Antibody (HB5), PE, eBioscience | Invitrogen 12-0219-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD21 Monoclonal Antibody (HB5), PE, eBioscience

catalog :

12-0219-42

quantity :

100 Tests

price :

US 268

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HB5

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; tbl 2	ChovancovÃ¡ J, Bernard T, StehlÃkovÃ¡ O, SÃ¡lek D, JanÃkovÃ¡ A, Mayer J, et al. Detection of Minimal Residual Disease in Mantle Cell Lymphoma. Establishment of Novel 8-Color Flow Cytometry Approach. Cytometry B Clin Cytom. 2014;: pubmed publisher
	Golinski M, Demeules M, Derambure C, Riou G, Maho Vaillant M, Boyer O, et al. CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors. Front Immunol. 2020;11:32 pubmed publisher
	Kang Y, Pietras E, Passegue E. Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia. J Exp Med. 2020;217: pubmed publisher
	Hu H, Luo M, Desmedt C, Nabavi S, Yadegarynia S, Hong A, et al. Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation. EBioMedicine. 2016;9:148-160 pubmed publisher
	Volk T, Pannicke U, Reisli I, Bulashevska A, Ritter J, BjÃ¶rkman A, et al. DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency. Hum Mol Genet. 2015;24:7361-72 pubmed publisher
	Portugal S, Tipton C, Sohn H, Kone Y, Wang J, Li S, et al. Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function. elife. 2015;4: pubmed publisher
	Ndungu F, Lundblom K, Rono J, Illingworth J, Eriksson S, Farnert A. Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers. Eur J Immunol. 2013;43:2919-29 pubmed publisher
	Muellenbeck M, Ueberheide B, Amulic B, Epp A, Fenyo D, Busse C, et al. Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies. J Exp Med. 2013;210:389-99 pubmed publisher
	Illingworth J, Butler N, Roetynck S, Mwacharo J, Pierce S, Bejon P, et al. Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol. 2013;190:1038-47 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD21 Monoclonal Antibody (HB5), PE, eBioscience

Catalog # :

12-0219-42

Quantity :

100 Tests

Price :

US 268

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.125 µg)/test

Species :

Human

Clone :

HB5

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.125 µg)/test

Aliases :

C3b/C4b receptor; C3-binding protein; C3BR; C3DR; C4BR; CD21; CD35; CD35 antigen; cell surface receptor for C3d; complement C3b/C4b receptor 1 (Knops blood group); complement C3d receptor; Complement C3d receptor (C3DR); complement C3d receptor 2; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3d/Epstein Barr virus) receptor 2; complement component 3b/4b receptor 1 (Knops blood group); complement component 3d receptor 2; complement component receptor 2; complement receptor 1 long isoform; complement receptor 2; complement receptor type 1; complement receptor type 1-like protein; complement receptor type 2; Complement Receptor type 2 (CR2); CR; CR1; Cr-1; CR1-L; Cr2; Cr-2; CVID7; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; expressed in B lymphocytes; KN; Knops blood group antigen; LOW QUALITY PROTEIN: complement receptor type 1; SLEB9

more info or order :

Invitrogen product webpage