CD21/CD35 Monoclonal Antibody (eBio4E3 (4E3)), PE, eBioscience | Invitrogen 12-0212-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD21/CD35 Monoclonal Antibody (eBio4E3 (4E3)), PE, eBioscience

catalog :

12-0212-82

quantity :

100 ug

price :

US 265.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

eBio4E3 (4E3)

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s3d	Baens M, Stirparo R, Lampi Y, Verbeke D, Vandepoel R, Cools J, et al. Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice. Eur J Immunol. 2018;48:1728-1738 pubmed publisher
flow cytometry; mouse; loading ...; fig 1c	Stengel K, Barnett K, Wang J, Liu Q, Hodges E, Hiebert S, et al. Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development. Proc Natl Acad Sci U S A. 2017;114:8608-8613 pubmed publisher
	Graham J, Yoachim S, Gould K. Estrogen Receptor Alpha Signaling Is Responsible for the Female Sex Bias in the Loss of Tolerance and Immune Cell Activation Induced by the Lupus Susceptibility Locus Sle1b. Front Immunol. 2020;11:582214 pubmed publisher
	Nguyen T, Schneppenheim J, Rudnik S, LÃ¼llmann Rauch R, Bernreuther C, Hermans Borgmeyer I, et al. Functional characterization of the lysosomal membrane protein TMEM192 in mice. Oncotarget. 2017;8:43635-43652 pubmed publisher
	ScottÃ C, Fanelli G, Hoong S, Romano M, Lamperti E, Sukthankar M, et al. Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells. Haematologica. 2016;101:91-100 pubmed publisher
	Huang L, Kong Y, Wang J, Sun J, Shi Q, Qiu Y. Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway. Mol Med Rep. 2015;12:4187-4195 pubmed publisher
	Bell C, Sun Y, Nowak U, Clark J, Howlett S, Pekalski M, et al. Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. J Autoimmun. 2015;56:66-80 pubmed publisher
	Peterson L, Pennington L, Shaw L, Brown M, Treacy E, Friend S, et al. SLAP deficiency decreases dsDNA autoantibody production. Clin Immunol. 2014;150:201-9 pubmed publisher
	Turner J, Narang P, Coles M, Mountford A. Blood flukes exploit Peyer's Patch lymphoid tissue to facilitate transmission from the mammalian host. PLoS Pathog. 2012;8:e1003063 pubmed publisher
	Szczepanek S, McNamara J, Secor E, Natarajan P, Guernsey L, Miller L, et al. Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease. Am J Pathol. 2012;181:1725-34 pubmed publisher
	Balkhi M, Willette Brown J, Zhu F, Chen Z, Liu S, Guttridge D, et al. IKK?-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012;119:5467-77 pubmed publisher
	Rahman Z, Shao W, Khan T, Zhen Y, Cohen P. Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J Immunol. 2010;185:5859-68 pubmed publisher
	Bryan M, Norris K. Genetic immunization converts the trypanosoma cruzi B-Cell mitogen proline racemase to an effective immunogen. Infect Immun. 2010;78:810-22 pubmed publisher
	Kozono Y, Abe R, Kozono H, Kelly R, Azuma T, Holers V. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J Immunol. 1998;160:1565-72 pubmed

product information

Product Type :

Antibody

Product Name :

CD21/CD35 Monoclonal Antibody (eBio4E3 (4E3)), PE, eBioscience

Catalog # :

12-0212-82

Quantity :

100 ug

Price :

US 265.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

eBio4E3 (4E3)

Isotype :

IgG2a, lambda

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

C3b/C4b receptor; C3-binding protein; C3DR; CD21; CD35; CD35 antigen; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2; complement receptor type 1; complement receptor type 2; CR; Cr1; Cr-1; Cr2; Cr-2; CVID7; EBV receptor; Epstein-Barr virus receptor; expressed in B lymphocytes; SLEB9

more info or order :

Invitrogen product webpage