CD21/CD35 Monoclonal Antibody (eBio8D9 (8D9)), PE, eBioscience™ | Invitrogen 12-0211-83 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD21/CD35 Monoclonal Antibody (eBio8D9 (8D9)), PE, eBioscience™

catalog :

12-0211-83

quantity :

200 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

clone name :

eBio8D9 (8D9)

reactivity :

mouse

application :

flow cytometry

citations: 12

Reference
Tang H, Wang H, Lin Q, Fan F, Zhang F, Peng X, et al. Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function. J Immunol. 2017;199:570-580 pubmed publisher
HÃ¼ttl S, KlÃ¤sener K, Schweizer M, Schneppenheim J, Oberg H, Kabelitz D, et al. Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells. J Immunol. 2015;195:1548-63 pubmed publisher
Jurkin J, Henkel T, Nielsen A, Minnich M, Popow J, Kaufmann T, et al. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 2014;33:2922-36 pubmed publisher
Promphet P, Bunarsa S, Sutheerawattananonda M, Kunthalert D. Immune enhancement activities of silk lutein extract from Bombyx mori cocoons. Biol Res. 2014;47:15 pubmed publisher
Holl T, Yang G, Kuraoka M, Verkoczy L, Alam S, Moody M, et al. Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. J Immunol. 2014;192:3269-79 pubmed publisher
Stolp J, Marino E, Batten M, Sierro F, Cox S, Grey S, et al. Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice. J Immunol. 2013;191:97-109 pubmed publisher
Gao H, Wu X, Sun Y, Zhou S, Silberstein L, Zhu Z. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012;287:29979-87 pubmed publisher
Birjandi S, Ippolito J, Ramadorai A, Witte P. Alterations in marginal zone macrophages and marginal zone B cells in old mice. J Immunol. 2011;186:3441-51 pubmed publisher
Holl T, Haynes B, Kelsoe G. Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. J Immunol Methods. 2010;354:53-67 pubmed publisher
Evans D, Connor M, Moss L, Lackay S, Leary J, Krunkosky T, et al. Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor. J Leukoc Biol. 2009;86:133-41 pubmed publisher
Vaitaitis G, Wagner D. High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. PLoS ONE. 2008;3:e2076 pubmed publisher
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD21/CD35 Monoclonal Antibody (eBio8D9 (8D9)), PE, eBioscience™

Catalog # :

12-0211-83

Quantity :

200 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

eBio8D9 (8D9)

Isotype :

IgG2a, lambda

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

C3b/C4b receptor; C3-binding protein; C3DR; CD21; CD35; CD35 antigen; complement C3d receptor; complement receptor 2; complement receptor type 1; complement receptor type 2; Cr1; Cr-1; Cr2; Cr-2; EBV receptor; expressed in B lymphocytes