This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD2 Monoclonal Antibody (RM2-5), PE, eBioscience
catalog :
12-0021-82
quantity :
100 ug
price :
US 272.00
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
RM2-5

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 12
Reference
Yue R, Shen B, Morrison S. Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton. elife. 2016;5: pubmed publisher
Peterson L, Pennington L, Shaw L, Brown M, Treacy E, Friend S, et al. SLAP deficiency decreases dsDNA autoantibody production. Clin Immunol. 2014;150:201-9 pubmed publisher
Zook E, Zhang S, Gerstein R, Witte P, Le P. Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche. J Immunol. 2013;191:5583-93 pubmed publisher
Lindner J, Wong C, Möller A, Nielsen P. A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1. Mol Cell Biol. 2013;33:4628-40 pubmed publisher
Thomas L, Peterson M, Long E. Cutting edge: NK cell licensing modulates adhesion to target cells. J Immunol. 2013;191:3981-5 pubmed publisher
Newrzela S, Cornils K, Heinrich T, Schläger J, Yi J, Lysenko O, et al. Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes. Mol Med. 2011;17:1223-32 pubmed publisher
Simard N, Konforte D, Tran A, Esufali J, Leonard W, Paige C. Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow. J Immunol. 2011;186:5244-53 pubmed publisher
Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek Burchardt M, Achilles J, et al. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS ONE. 2011;6:e17314 pubmed publisher
Ferreira C, Frenzke M, Leonard V, Welstead G, Richardson C, Cattaneo R. Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). J Virol. 2010;84:3033-42 pubmed publisher
Milne C, Corfe S, Paige C. Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis. J Immunol. 2008;180:2839-47 pubmed
Matsumura Takeda K, Sogo S, Isakari Y, Harada Y, Nishioka K, Kawakami T, et al. CD41+/CD45+ cells without acetylcholinesterase activity are immature and a major megakaryocytic population in murine bone marrow. Stem Cells. 2007;25:862-70 pubmed
Dai X, Chen Y, Schuman J, Hua Z, Adamson J, Wen R, et al. Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol. 2006;26:88-99 pubmed
product information
Product Type :
Antibody
Product Name :
CD2 Monoclonal Antibody (RM2-5), PE, eBioscience
Catalog # :
12-0021-82
Quantity :
100 ug
Price :
US 272.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
RM2-5
Isotype :
IgG2b, lambda
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
Cd2; CD2 antigen; CD2 antigen (p50), sheep red blood cell receptor; CD2 molecule; CD2R; cluster of differentiation 2; Erythrocyte receptor; FLJ46032; LFA2; LFA-2; LFA-3 receptor; Ly37; Ly-37; lymphocyte antigen 37; OX34; OX-34; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; Rosette receptor; SRBC; surface immunoglobulin superfamily molecule; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA