CD1a Monoclonal Antibody (HI149), PE, eBioscience | Invitrogen 12-0019-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD1a Monoclonal Antibody (HI149), PE, eBioscience

catalog :

12-0019-42

quantity :

100 Tests

price :

US 310

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HI149

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Ziblat A, Domaica C, Spallanzani R, Iraolagoitia X, Rossi L, Avila D, et al. IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness. Eur J Immunol. 2015;45:192-202 pubmed publisher
	Bonte S, De Munter S, Billiet L, Goetgeluk G, Ingels J, Jansen H, et al. In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality. Oncoimmunology. 2021;10:1954800 pubmed publisher
	Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, et al. Regulatory Dendritic Cells Restrain NK Cell IFN-Î³ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors. J Immunol. 2015;195:2141-8 pubmed publisher
	Kowalczyk A, D Souza C, Zhang L. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol. 2014;44:1143-55 pubmed publisher
	Singh V, Prajeeth C, Gudi V, Benardais K, Voss E, Stangel M. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells. Clin Exp Immunol. 2013;173:288-97 pubmed publisher
	Hamilton E, Pearce L, Morgan L, Robinson S, Ware V, Brennan P, et al. Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells. Br J Haematol. 2012;158:589-99 pubmed publisher
	Ramanathapuram L, Hopkin D, Kurago Z. Dendritic Cells (DC) Facilitate Detachment of Squamous Carcinoma Cells (SCC), While SCC Promote an Immature CD16(+) DC Phenotype and Control DC Migration. Cancer Microenviron. 2013;6:41-55 pubmed publisher
	Li W, Katz B, Spinola S. Haemophilus ducreyi lipooligosaccharides induce expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase via type I interferons and tumor necrosis factor alpha in human dendritic cells. Infect Immun. 2011;79:3338-47 pubmed publisher
	Lechner M, Liebertz D, Epstein A. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol. 2010;185:2273-84 pubmed publisher
	Van Pottelberge G, Bracke K, Demedts I, De Rijck K, Reinartz S, van Drunen C, et al. Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD. Respir Res. 2010;11:35 pubmed publisher
	Shimura C, Satoh T, Igawa K, Aritake K, Urade Y, Nakamura M, et al. Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. Am J Pathol. 2010;176:227-37 pubmed publisher
	Pedersen A, Holmstrøm K, Jensen S, Fuchs D, Rasmussen S, Kvistborg P, et al. Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells. Clin Exp Immunol. 2009;157:48-59 pubmed publisher
	Watanabe M, Kashiwakura Y, Huang P, Ochiai K, Futami J, Li S, et al. Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression. Int J Oncol. 2009;34:657-63 pubmed
	Ohta S, Ueda Y, Yaguchi M, Matsuzaki Y, Nakamura M, Toyama Y, et al. Isolation and characterization of dendritic cells from common marmosets for preclinical cell therapy studies. Immunology. 2008;123:566-74 pubmed
	Martínez Pomar N, Raga S, Ferrer J, Pons J, Munoz Saá I, Julià M, et al. Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene. Clin Exp Immunol. 2006;144:233-8 pubmed
	McCully M, Chau T, Luke P, Blake P, Madrenas J. Characterization of human peritoneal dendritic cell precursors and their involvement in peritonitis. Clin Exp Immunol. 2005;139:513-25 pubmed

product information

Product Type :

Antibody

Product Name :

CD1a Monoclonal Antibody (HI149), PE, eBioscience

Catalog # :

12-0019-42

Quantity :

100 Tests

Price :

US 310

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human

Clone :

HI149

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a

more info or order :

Invitrogen product webpage