Human CD14 (soluble) Recombinant Protein, PeproTech | Invitrogen 110-01-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human CD14 (soluble) Recombinant Protein, PeproTech

catalog :

110-01-50UG

quantity :

50 ug

price :

US 227.00

citations: 7

Reference
Sanjurjo L, Castelblanco E, Julve J, Villalmanzo N, T xe9 llez x, Ramírez Morros A, et al. Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14. Antioxidants (Basel). 2023;12: pubmed publisher
Chung M, Lee S, Chen D, Kim U, Kim Y, Kim S, et al. Effects of Different Calcium Silicate Cements on the Inflammatory Response and Odontogenic Differentiation of Lipopolysaccharide-Stimulated Human Dental Pulp Stem Cells. Materials (Basel). 2019;12: pubmed publisher
Saravanan R, Holdbrook D, Petrlova J, Singh S, Berglund N, Choong Y, et al. Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides. Nat Commun. 2018;9:2762 pubmed publisher
Andrukhov O, Hong J, Andrukhova O, Blufstein A, Moritz A, Rausch fan X. Response of human periodontal ligament stem cells to IFN-γ and TLR-agonists. Sci Rep. 2017;7:12856 pubmed publisher
Hu L, Hu X, Long K, Gao C, Dong H, Zhong Q, et al. Extraordinarily potent proinflammatory properties of lactoferrin-containing immunocomplexes against human monocytes and macrophages. Sci Rep. 2017;7:4230 pubmed publisher
Ishida A, Akita K, Mori Y, Tanida S, Toda M, Inoue M, et al. Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33. J Biol Chem. 2014;289:25341-50 pubmed publisher
Ranoa D, Kelley S, Tapping R. Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex. J Biol Chem. 2013;288:9729-41 pubmed publisher

product information

Product Type :

Protein

Product Name :

Human CD14 (soluble) Recombinant Protein, PeproTech

Catalog # :

110-01-50UG

Quantity :

50 ug

Price :

US 227.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Aliases :

CD 14; CD14; CD14 antigen; CD14 molecule; cd14 monocyte; lipopolysaccharide receptor; lipoprotein receptor; LPSR antibody; monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14, membrane-bound form; Monocyte differentiation antigen CD14, urinary form; monocyte differentiation antigen CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; myeloid membrane glycoprotein precursor; sCD14; soluble CD14