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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-4 Monoclonal Antibody (BVD6-24G2), FITC, eBioscience™
catalog :
11-7042-81
quantity :
50 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
BVD6-24G2
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 87
Published Application/Species/Sample/Dilution | Reference |
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| Boyoglu Barnum S, Chirkova T, Todd S, Barnum T, Gaston K, Jorquera P, et al. Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice. J Virol. 2014;88:10569-83 pubmed publisher
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| Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
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Chen Y, Zhang J, Li C, Sun Q, Jiang X. Obesity enhances Th2 inflammatory response via natural killer T cells in a murine model of allergic asthma. Int J Clin Exp Med. 2015;8:15403-12 pubmed
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Morris K, Castillo E, Ray A, Weston L, Nofchissey R, Hanson J, et al. Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses. Oncotarget. 2015;6:22338-47 pubmed
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Paveley R, Aynsley S, Turner J, Bourke C, Jenkins S, Cook P, et al. The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFN? production. Int J Parasitol. 2011;41:1335-45 pubmed publisher
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Besche V, Wiechmann N, Castor T, Trojandt S, Höhn Y, Kunkel H, et al. Dendritic cells lentivirally engineered to overexpress interleukin-10 inhibit contact hypersensitivity responses, despite their partial activation induced by transduction-associated physical stress. J Gene Med. 2010;12:231-43 pubmed publisher
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Voehringer D, Liang H, Locksley R. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol. 2008;180:4742-53 pubmed
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Rankin A, Reed A, Oh S, Cozzo Picca C, Guay H, Larkin J, et al. CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis. J Immunol. 2008;180:833-41 pubmed
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Castilow E, Olson M, Meyerholz D, Varga S. Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus. J Virol. 2008;82:2196-207 pubmed
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Olson M, Varga S. CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease. J Immunol. 2007;179:5415-24 pubmed
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Kin N, Sanders V. CD86 regulates IgG1 production via a CD19-dependent mechanism. J Immunol. 2007;179:1516-23 pubmed
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Mayol K, Munier S, Beck A, Verrier B, Guillon C. Design and characterization of an HIV-1 Tat mutant: inactivation of viral and cellular functions but not antigenicity. Vaccine. 2007;25:6047-60 pubmed
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Denkinger C, Denkinger M, Forsthuber T. Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation. Cell Immunol. 2007;246:46-54 pubmed
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Mutou Y, Ibuki Y, Kojima S. Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in NC/Nga mice. Photodermatol Photoimmunol Photomed. 2007;23:135-44 pubmed
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Grigorian A, Lee S, Tian W, Chen I, Gao G, Mendelsohn R, et al. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem. 2007;282:20027-35 pubmed
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Kroenke M, Segal B. Th17 and Th1 responses directed against the immunizing epitope, as opposed to secondary epitopes, dominate the autoimmune repertoire during relapses of experimental autoimmune encephalomyelitis. J Neurosci Res. 2007;85:1685-93 pubmed
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Puertas M, Carrillo J, Pastor X, Ampudia R, Alba A, Planas R, et al. Phenotype and functional characteristics of islet-infiltrating B-cells suggest the existence of immune regulatory mechanisms in islet milieu. Diabetes. 2007;56:940-9 pubmed
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Maruyama T, Shiba T, Iizuka H, Matsuda T, Kurohane K, Imai Y. Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity. Microbiol Immunol. 2007;51:321-6 pubmed
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Maruyama T, Iizuka H, Tobisawa Y, Shiba T, Matsuda T, Kurohane K, et al. Influence of local treatments with capsaicin or allyl isothiocyanate in the sensitization phase of a fluorescein-isothiocyanate-induced contact sensitivity model. Int Arch Allergy Immunol. 2007;143:144-54 pubmed
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Joyee A, Qiu H, Wang S, Fan Y, Bilenki L, Yang X. Distinct NKT cell subsets are induced by different Chlamydia species leading to differential adaptive immunity and host resistance to the infections. J Immunol. 2007;178:1048-58 pubmed
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Sakai T, Kogiso M, Mitsuya K, Komatsu T, Yamamoto S. Genistein enhances antigen-specific cytokine production in female DO11.10 transgenic mice. J Nutr Sci Vitaminol (Tokyo). 2006;52:327-32 pubmed
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Kubota K. A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection. J Immunol. 2006;176:7576-88 pubmed
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Tanaka T, Tago F, Fang S, Shimura N, Kojima S. Repeated 0.5-Gy gamma-ray irradiation attenuates autoimmune manifestations in MRL-lpr/lpr mice. Int J Radiat Biol. 2005;81:731-40 pubmed
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Kort J, Kawamura K, Fugger L, Weissert R, Forsthuber T. Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice. J Neuroimmunol. 2006;173:23-34 pubmed
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Haring J, Badovinac V, Olson M, Varga S, Harty J. In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor. J Immunol. 2005;175:3117-22 pubmed
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Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, et al. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J Immunol. 2005;175:2374-80 pubmed
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Machlenkin A, Goldberger O, Tirosh B, Paz A, Volovitz I, Bar Haim E, et al. Combined dendritic cell cryotherapy of tumor induces systemic antimetastatic immunity. Clin Cancer Res. 2005;11:4955-61 pubmed
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Fang S, Tago F, Tanaka T, Simura N, Muto Y, Goto R, et al. Repeated irradiations with gamma-rays at a Dose of 0.5 Gy may exacerbate asthma. J Radiat Res. 2005;46:151-6 pubmed
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Fang S, Tanaka T, Tago F, Okamoto T, Kojima S. Immunomodulatory effects of gyokuheifusan on INF-gamma/IL-4 (Th1/Th2) balance in ovalbumin (OVA)-induced asthma model mice. Biol Pharm Bull. 2005;28:829-33 pubmed
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Anderson C, Mendez S, Sacks D. Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice. J Immunol. 2005;174:2934-41 pubmed
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product information
Product Type :
Antibody
Product Name :
IL-4 Monoclonal Antibody (BVD6-24G2), FITC, eBioscience™
Catalog # :
11-7042-81
Quantity :
50 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
BVD6-24G2
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
more info or order :
company information

Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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