IL-1 beta Monoclonal Antibody (CRM56), FITC, eBioscience™ | Invitrogen 11-7018-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-1 beta Monoclonal Antibody (CRM56), FITC, eBioscience™

catalog :

11-7018-41

quantity :

25 Tests

price :

US 116

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

CRM56

reactivity :

human

application :

flow cytometry

citations: 8

Reference
Falc xf3 n Cama V, Montero Gonz xe1 lez T, Acosta Medina E, Guillen Nieto G, Berlanga Acosta J, Fern xe1 ndez Ortega C, et al. Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis. Arch Virol. 2023;168:96 pubmed publisher
Kahraman T, Gucluler G, Simsek I, Yagci F, Yildirim M, Ozen C, et al. Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity. J Extracell Vesicles. 2017;6:1284449 pubmed publisher
Rohnalter V, Roth K, Finkernagel F, Adhikary T, Obert J, Dorzweiler K, et al. A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype. Oncotarget. 2015;6:40005-25 pubmed publisher
Sullivan J, Jankowska Gan E, Shi L, Roenneburg D, Hegde S, Greenspan D, et al. Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses. Am J Transplant. 2014;14:1512-22 pubmed publisher
Krishnan S, Wilson E, Sheikh V, Rupert A, Mendoza D, Yang J, et al. Evidence for innate immune system activation in HIV type 1-infected elite controllers. J Infect Dis. 2014;209:931-9 pubmed publisher
Mirza R, Fang M, Ennis W, Koh T. Blocking interleukin-1? induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes. 2013;62:2579-87 pubmed publisher
Vohra P, Poxton I. Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile. FEMS Immunol Med Microbiol. 2012;65:96-104 pubmed publisher
Meyers A, Shah R, Gottlieb P, Zipris D. Altered Toll-like receptor signaling pathways in human type 1 diabetes. J Mol Med (Berl). 2010;88:1221-31 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-1 beta Monoclonal Antibody (CRM56), FITC, eBioscience™

Catalog # :

11-7018-41

Quantity :

25 Tests

Price :

US 116

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.125 µg)/test

Species :

Human

Clone :

CRM56

Isotype :

IgG1

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.125 µg)/test

Aliases :

catabolin; cytokine; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; Il-1b; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 beta-like; Interleukin-1b; interleukin-beta; LOC100052414; lymphocyte proliferation-potentiating factor; preinterleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta