MHC Class II (I-Ek) Monoclonal Antibody (14-4-4S), FITC, eBioscience | Invitrogen 11-5980-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MHC Class II (I-Ek) Monoclonal Antibody (14-4-4S), FITC, eBioscience

catalog :

11-5980-82

quantity :

100 µg

price :

US 156

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

14-4-4S

The same clone is also sold as:

BioLegend: 110211, 110205

reactivity :

mouse, rat

application :

flow cytometry

citations: 11

Reference
Clubb J, Kudling T, Girych M, Haybout L, Pakola S, Hamdan F, et al. Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting. Front Immunol. 2023;14:1060540 pubmed publisher
Quixabeira D, Zafar S, Santos J, Cervera Carrascon V, Havunen R, Kudling T, et al. Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control. Front Immunol. 2021;12:674400 pubmed publisher
Hay C, Sult E, Huang Q, Mulgrew K, Fuhrmann S, McGlinchey K, et al. Targeting CD73 in the tumor microenvironment with MEDI9447. Oncoimmunology. 2016;5:e1208875 pubmed publisher
Pamir N, Liu N, Irwin A, Becker L, Peng Y, Ronsein G, et al. Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion. J Biol Chem. 2015;290:14656-67 pubmed publisher
Lewkowich I, Lajoie S, Stoffers S, Suzuki Y, Richgels P, Dienger K, et al. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunol. 2013;6:728-39 pubmed publisher
Farquhar C, Paterson A, Cobbold S, Garcia Rueda H, Fairchild P, Yates S, et al. Tolerogenicity is not an absolute property of a dendritic cell. Eur J Immunol. 2010;40:1728-37 pubmed publisher
Liu J, Ruckwardt T, Chen M, Johnson T, Graham B. Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model. J Virol. 2009;83:4934-41 pubmed publisher
Turnquist H, Sumpter T, Tsung A, Zahorchak A, Nakao A, Nau G, et al. IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol. 2008;181:62-72 pubmed
Robbins C, Franco F, Mouded M, Cernadas M, Shapiro S. Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J Immunol. 2008;180:6623-8 pubmed
Tseng S, Liu M, Dustin M. CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J Immunol. 2005;175:7829-36 pubmed
Augello A, Tasso R, Negrini S, Amateis A, Indiveri F, Cancedda R, et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol. 2005;35:1482-90 pubmed

product information

Product Type :

Antibody

Product Name :

MHC Class II (I-Ek) Monoclonal Antibody (14-4-4S), FITC, eBioscience

Catalog # :

11-5980-82

Quantity :

100 µg

Price :

US 156

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse, Rat

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse, Rat

Clone :

14-4-4S

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

AI323765; cell surface glycoprotein; E-alpha-f; H-2 class II histocompatibility antigen, E-D alpha chain; H-2 class II histocompatibility antigen, E-K alpha chain; H-2 class II histocompatibility antigen, E-U alpha chain; H-2 class II histocompatibility antigen, I-E beta chain; H-2Ea; H2-Ea; H2-Ea-ps; H2Eb; H-2Eb; H2-Eb1; H2-IE-alpha; histocompatibility 2, class II antigen E alpha; histocompatibility 2, class II antigen E alpha, pseudogene; histocompatibility 2, class II antigen E beta; Ia3; Ia-3; Ia4; Ia-4; I-E alpha MHC class II; I-E beta MHC class II; I-Ealpha; major histocompatibility complex H-2E beta chain; MGC117888; MHC class II antigen E alpha; MHC class II IE-b; MHC class II protein; MHC H2-IE-beta cell surface glycoprotein