NKG2A/C/E Monoclonal Antibody (20d5), FITC, eBioscience™ | Invitrogen 11-5896-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NKG2A/C/E Monoclonal Antibody (20d5), FITC, eBioscience™

catalog :

11-5896-85

quantity :

500 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

20d5

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 2	Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed publisher
	Wang X, Piersma S, Nelson C, Dai Y, Christensen T, Lazear E, et al. A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement. elife. 2018;7: pubmed publisher
	Riese P, Trittel S, May T, Cicin Sain L, Chambers B, Guzman C. Activated NKT cells imprint NK-cell differentiation, functionality and education. Eur J Immunol. 2015;45:1794-807 pubmed publisher
	Pyzik M, Dumaine A, Dumaine A, Charbonneau B, Fodil Cornu N, Jonjic S, et al. Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo. J Immunol. 2014;193:6061-9 pubmed publisher
	Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
	Sohlberg E, Saghafian Hedengren S, Rasul E, Marchini G, Nilsson C, Klein E, et al. Cytomegalovirus-seropositive children show inhibition of in vitro EBV infection that is associated with CD8+CD57+ T cell enrichment and IFN-?. J Immunol. 2013;191:5669-76 pubmed publisher
	Trotta R, Chen L, Costinean S, Josyula S, Mundy Bosse B, Ciarlariello D, et al. Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells. Blood. 2013;121:3126-34 pubmed publisher
	Alvarez Breckenridge C, Yu J, Price R, Wojton J, Pradarelli J, Mao H, et al. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med. 2012;18:1827-34 pubmed publisher
	Yang R, Kalogriopoulos N, Rakhmilevich A, Ranheim E, Seo S, Kim K, et al. Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention. J Immunol. 2012;189:2656-64 pubmed publisher
	Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, et al. Tyrosine kinase Btk is required for NK cell activation. J Biol Chem. 2012;287:23769-78 pubmed publisher
	Yoshizawa K, Nakajima S, Notake T, Miyagawa S, Hida S, Taki S. IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice. J Immunol. 2011;187:5162-9 pubmed publisher
	Pegram H, Haynes N, Smyth M, Kershaw M, Darcy P. Characterizing the anti-tumor function of adoptively transferred NK cells in vivo. Cancer Immunol Immunother. 2010;59:1235-46 pubmed publisher
	Lucas M, Vonarbourg C, Aichele P, Diefenbach A. Studying NK cell/dendritic cell interactions. Methods Mol Biol. 2010;612:97-126 pubmed publisher
	Aust J, Gays F, Mickiewicz K, Buchanan E, Brooks C. The expression and function of the NKRP1 receptor family in C57BL/6 mice. J Immunol. 2009;183:106-16 pubmed publisher
	Jänner N, Hahnke K, Mollenkopf H, Steinhoff U, Kaufmann S, Mittrücker H. Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology. 2008;125:38-47 pubmed publisher
	Shiraishi K, Ishiwata Y, Nakagawa K, Yokochi S, Taruki C, Akuta T, et al. Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha. Clin Cancer Res. 2008;14:1159-66 pubmed publisher
	Cho J, Boyman O, Kim H, Hahm B, Rubinstein M, Ramsey C, et al. An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med. 2007;204:1787-801 pubmed
	Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, et al. The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood. 2007;110:3202-8 pubmed
	Boos M, Yokota Y, Eberl G, Kee B. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med. 2007;204:1119-30 pubmed
	Das G, Das J, Eynott P, Zhang Y, Bothwell A, Van Kaer L, et al. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med. 2006;203:2603-11 pubmed
	Rogers S, Rouhi A, Takei F, Mager D. A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells. J Immunol. 2006;177:414-21 pubmed
	Claassen E, Van der Kant P, Rychnavska Z, van Bleek G, Easton A, van der Most R. Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J Immunol. 2005;175:6597-604 pubmed
	Uldrich A, Crowe N, Kyparissoudis K, Pellicci D, Zhan Y, Lew A, et al. NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge. J Immunol. 2005;175:3092-3101 pubmed
	Gays F, Martin K, Kenefeck R, Aust J, Brooks C. Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J Immunol. 2005;175:2938-47 pubmed
	Tassi I, Presti R, Kim S, Yokoyama W, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol. 2005;175:749-54 pubmed

product information

Product Type :

Antibody

Product Name :

NKG2A/C/E Monoclonal Antibody (20d5), FITC, eBioscience™

Catalog # :

11-5896-85

Quantity :

500 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 µg/test

Species :

Mouse

Clone :

20d5

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test

Aliases :

CD159a; cd159c; cd159e; Cluster of Differentiation 159a; killer cell lectin-like receptor subfamily C, member 1; killer cell lectin-like receptor subfamily C, member 2; killer cell lectin-like receptor subfamily C, member 3; Klrc1; Klrc2; Klrc3; natural killer cell group 2E cell receptor; NKG2; NKG2A; NKG2-A/NKG2-B type II integral membrane protein; NKG2B; NKG2C; Nkg2e

more info or order :

Invitrogen product webpage