TCR gamma/delta Monoclonal Antibody (UC7-13D5), FITC, eBioscience™ | Invitrogen 11-5811-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR gamma/delta Monoclonal Antibody (UC7-13D5), FITC, eBioscience™

catalog :

11-5811-82

quantity :

100 µg

price :

US 309.00

clonality :

monoclonal

host :

hamsters

conjugate :

FITC

clone name :

UC7-13D5

reactivity :

mouse

application :

flow cytometry, mass cytometry

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
mass cytometry; mouse; 1:100; loading ...; fig 3, s2	Rosshart S, Herz J, Vassallo B, Hunter A, Wall M, Badger J, et al. Laboratory mice born to wild mice have natural microbiota and model human immune responses. Science. 2019;365: pubmed publisher
	Kim H, Jang S, Lee W, Kim K, Sohn H, Hwang S, et al. PTEN drives Th17 cell differentiation by preventing IL-2 production. J Exp Med. 2017;214:3381-3398 pubmed publisher
	Schaffert S, Loh C, Wang S, Arnold C, Axtell R, Newell E, et al. mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol. 2015;195:1470-9 pubmed publisher
	Akitsu A, Ishigame H, Kakuta S, Chung S, Ikeda S, Shimizu K, et al. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)VÎ³6(+)Î³Î´ T cells. Nat Commun. 2015;6:7464 pubmed publisher
	Park S, Mathur R, Long M, Hosh N, Hao L, Hayden M, et al. T regulatory cells maintain intestinal homeostasis by suppressing ?? T cells. Immunity. 2010;33:791-803 pubmed publisher
	Blache C, Adriouch S, Calbo S, Drouot L, Dulauroy S, Arnoult C, et al. Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells. J Immunol. 2009;183:4182-6 pubmed publisher
	Koenecke C, Chennupati V, Schmitz S, Malissen B, Forster R, Prinz I. In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells. Eur J Immunol. 2009;39:372-9 pubmed publisher
	Dupré S, Redelman D, Hunter K. Microenvironment of the murine mammary carcinoma 4T1: endogenous IFN-gamma affects tumor phenotype, growth, and metastasis. Exp Mol Pathol. 2008;85:174-88 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TCR gamma/delta Monoclonal Antibody (UC7-13D5), FITC, eBioscience™

Catalog # :

11-5811-82

Quantity :

100 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

UC7-13D5

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@

more info or order :

Invitrogen product webpage