TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), FITC, eBioscience™ | Invitrogen 11-5796-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), FITC, eBioscience™

catalog :

11-5796-80

quantity :

25 µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

MR9-4

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Das D, Feng Y, Mallis R, Li X, Keskin D, Hussey R, et al. Force-dependent transition in the T-cell receptor Î²-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015;112:1517-22 pubmed publisher
	Wang Q, He H, Chen D, Wang C, Xu Y, Song W. Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice. Oncotarget. 2017;8:93414-93425 pubmed publisher
	Joedicke J, Dietze K, Zelinskyy G, Dittmer U. The phenotype and activation status of regulatory T cells during Friend retrovirus infection. Virol Sin. 2014;29:48-60 pubmed publisher
	Pletinckx K, Lutz M. Dendritic cells generated with Flt3L and exposed to apoptotic cells lack induction of T cell anergy and Foxp3? regulatory T cell conversion in vitro. Immunobiology. 2014;219:230-40 pubmed publisher
	Oda H, Tamehiro N, Patrick M, Hayakawa K, Suzuki H. Differential requirement for RhoH in development of TCR?? CD8?? IELs and other types of T cells. Immunol Lett. 2013;151:1-9 pubmed publisher
	Kaluza K, Kottke T, Diaz R, Rommelfanger D, Thompson J, Vile R. Adoptive transfer of cytotoxic T lymphocytes targeting two different antigens limits antigen loss and tumor escape. Hum Gene Ther. 2012;23:1054-64 pubmed publisher
	Kaluza K, Thompson J, Kottke T, Flynn Gilmer H, Knutson D, Vile R. Adoptive T cell therapy promotes the emergence of genomically altered tumor escape variants. Int J Cancer. 2012;131:844-54 pubmed publisher
	Savage A, Constantinides M, Bendelac A. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol. 2011;186:5801-6 pubmed publisher
	Li L, Kim J, Boussiotis V. IL-1?-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol. 2010;185:4148-53 pubmed publisher
	Kenna T, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, et al. Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function. J Immunol. 2010;184:598-606 pubmed publisher
	Seavey M, Mosmann T. Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization. Vaccine. 2009;27:2342-9 pubmed publisher
	del Rio M, Rodriguez Barbosa J, Kremmer E, Forster R. CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol. 2007;178:6861-6 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), FITC, eBioscience™

Catalog # :

11-5796-80

Quantity :

25 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

MR9-4

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

TCR V beta5.1; TCR V beta5.2; TCRV beta 5.1; TCRV beta 5.2; TCRV beta5.1; TCRV beta5.2; Vb5.1; Vb5.2; Vbeta5.1; Vbeta5.2

more info or order :

Invitrogen product webpage