IgM Monoclonal Antibody (II/41), FITC, eBioscience™ | Invitrogen 11-5790-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IgM Monoclonal Antibody (II/41), FITC, eBioscience™

catalog :

11-5790-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

II/41

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 37

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 1b	Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
	Fallet B, Hao Y, Florova M, Cornille K, de Los Aires A, Girelli Zubani G, et al. Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses. Cell Rep. 2020;30:1013-1026.e7 pubmed publisher
	Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, et al. TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells. FEBS J. 2019;286:3566-3581 pubmed publisher
	Weng Q, Hu F, Zhang M, Dong Y, Lv C, Wang Y, et al. A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regen (Lond). 2018;7:7-15 pubmed publisher
	Stark A, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, et al. PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nat Commun. 2018;9:3174 pubmed publisher
	Wang X, Zhang Y, Wang Z, Liu X, Zhu G, Han G, et al. Anti?IL?39 (IL?23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus?like mice. Mol Med Rep. 2017;: pubmed publisher
	Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz V. TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017;214:1269-1280 pubmed publisher
	Ikawa T, Masuda K, Endo T, Endo M, Isono K, Koseki Y, et al. Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes Dev. 2016;30:2475-2485 pubmed
	Lund P, Elias J, Davis M. Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells. J Immunol. 2016;197:3086-3098 pubmed
	van der Velden D, Lagraauw H, Wezel A, Launay P, Kuiper J, Huizinga T, et al. Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile. Arthritis Res Ther. 2016;18:138 pubmed publisher
	Cheong T, Compagno M, Chiarle R. Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Nat Commun. 2016;7:10934 pubmed publisher
	Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, et al. Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A. 2016;113:1256-60 pubmed publisher
	Tomokatsu I, Masuda K, Huijskens M, Satoh R, Kakugawa K, Agata Y, et al. Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells. Stem Cell Reports. 2015;5:716-27 pubmed
	Canver M, SMITH E, Sher F, Pinello L, Sanjana N, Shalem O, et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature. 2015;527:192-7 pubmed publisher
	Palmer V, Aziz Seible R, Kassmeier M, Rothermund M, Perry G, Swanson P. VprBP Is Required for Efficient Editing and Selection of IgÎº+ B Cells, but Is Dispensable for IgÎ»+ and Marginal Zone B Cell Maturation and Selection. J Immunol. 2015;195:1524-37 pubmed publisher
	Weindel C, Richey L, Bolland S, Mehta A, Kearney J, Huber B. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy. 2015;11:1010-24 pubmed publisher
	Li W, Yu R, Ma B, Yang Y, Jiao X, Liu Y, et al. Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production. J Immunol. 2015;194:2596-606 pubmed publisher
	Khoo L, Thiam C, Soh S, Angeli V. Splenic extrafollicular reactions and BM plasma cells sustain IgM response associated with hypercholesterolemia. Eur J Immunol. 2015;45:1300-12 pubmed publisher
	Cho J, Seo J, Lim C, Yang L, Shiratsuchi T, Lee M, et al. Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ. 2015;22:1437-50 pubmed publisher
	Vettermann C, Timblin G, Lim V, Lai E, Schlissel M. The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination. PLoS ONE. 2015;10:e0113824 pubmed publisher
	Reynolds A, Kuraoka M, Kelsoe G. Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. J Immunol. 2015;194:231-42 pubmed publisher
	Kläsener K, Maity P, Hobeika E, Yang J, Reth M. B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. elife. 2014;3:e02069 pubmed publisher
	Rouaud P, Saintamand A, Saad F, Carrion C, Lecardeur S, Cogne M, et al. Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region. J Exp Med. 2014;211:975-85 pubmed publisher
	Olive V, SABIO E, Bennett M, De Jong C, Biton A, McGann J, et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. elife. 2013;2:e00822 pubmed publisher
	Jones D, Jones M, Deiulio G, Racine R, MacNamara K, Winslow G. B cell activating factor inhibition impairs bacterial immunity by reducing T cell-independent IgM secretion. Infect Immun. 2013;81:4490-7 pubmed publisher
	Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
	Austin W, Armijo A, Campbell D, Singh A, Hsieh T, Nathanson D, et al. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012;209:2215-28 pubmed publisher
	Yu M, Chen Y, He Y, Podd A, Fu G, Wright J, et al. Critical role of B cell lymphoma 10 in BAFF-regulated NF-?B activation and survival of anergic B cells. J Immunol. 2012;189:5185-93 pubmed publisher
	McNamee E, Masterson J, Jedlicka P, Collins C, Williams I, Rivera Nieves J. Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis. Gut. 2013;62:53-62 pubmed publisher
	Todd E, Deady L, Morley S. The actin-bundling protein L-plastin is essential for marginal zone B cell development. J Immunol. 2011;187:3015-25 pubmed publisher
	Wuerzberger Davis S, Chen Y, Yang D, Kearns J, Bates P, Lynch C, et al. Nuclear export of the NF-?B inhibitor I?B? is required for proper B cell and secondary lymphoid tissue formation. Immunity. 2011;34:188-200 pubmed publisher
	Racine R, McLaughlin M, Jones D, Wittmer S, MacNamara K, Woodland D, et al. IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection. J Immunol. 2011;186:1011-21 pubmed publisher
	Santiago M, Benitez R, Montano M, Hasenkrug K, Greene W. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J Immunol. 2010;185:1114-23 pubmed publisher
	Capasso M, Bhamrah M, Henley T, Boyd R, Langlais C, Cain K, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol. 2010;11:265-72 pubmed publisher
	Olive V, Bennett M, Walker J, Ma C, Jiang I, Cordon Cardo C, et al. miR-19 is a key oncogenic component of mir-17-92. Genes Dev. 2009;23:2839-49 pubmed publisher
	Schuman J, Chen Y, Podd A, Yu M, Liu H, Wen R, et al. A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood. 2009;113:4566-74 pubmed publisher
	Bai L, Chen Y, He Y, Dai X, Lin X, Wen R, et al. Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. Mol Cell Biol. 2007;27:5957-67 pubmed

product information

Product Type :

Antibody

Product Name :

IgM Monoclonal Antibody (II/41), FITC, eBioscience™

Catalog # :

11-5790-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test, Immunocytochemistry: 10 µg/mL, Immunohistochemistry: Assay-Dependent

Species :

Mouse

Clone :

II/41

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

IgM (Immunoglobulin M) is expressed intracellularly during the early stages of B lymphopoiesis, and then on the surface of more mature B cells in the bone marrow and peripheral B cells. The isotype of a primary antibody and its application can result in background staining. Primary antibody background noise can be caused by binding to Fc receptors on target cells; by non-specific interactions with cellular proteins, carbohydrates, and lipids; or by cell autofluorescence. Isotype control antibodies can act as negative controls to help differentiate non-specific background signal from specific antibody signal because they have no relevant specificity to a target antigen. While isotype controls are most commonly used in flow cytometry, they are also useful in other applications such as chromatin immunoprecipitation (ChIP), immunohistochemistry, and gel shifts. Isotype controls should match with the primary antibody species and isotype so that the level of specific staining by the primary antibody may be accurately determined. If using directly labeled primary antibodies, the isotype control works best if conjugated with the same label as the test antibody.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test, Immunocytochemistry: 10 µg/mL, Immunohistochemistry: Assay-Dependent

Aliases :

AGM1; AI326478; Igh6; Igh-6; Ighm; Igh-M; Igm; immunoglobulin heavy constant mu; MU; muH; VH

more info or order :

Invitrogen product webpage