MHC Class II (I-A) Monoclonal Antibody (NIMR-4), FITC, eBioscience | Invitrogen 11-5322-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MHC Class II (I-A) Monoclonal Antibody (NIMR-4), FITC, eBioscience

catalog :

11-5322-81

quantity :

50 µg

price :

US 122

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

NIMR-4

The same clone is also sold as:

MyBioSource: MBS673637

reactivity :

mouse

application :

flow cytometry

citations: 36

Reference
Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lénárt N, et al. Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med. 2021;218: pubmed publisher
Kim H, Park J, Park J, Yasmin F, Kim C, Oh S, et al. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. J Hematol Oncol. 2021;14:43 pubmed publisher
Efimova I, Catanzaro E, Van der Meeren L, Turubanova V, Hammad H, Mishchenko T, et al. Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity. J Immunother Cancer. 2020;8: pubmed publisher
Kuznetsova T, Smolina T, Makarenkova I, Ivanushko L, Persiyanova E, Ermakova S, et al. Immunoadjuvant Activity of Fucoidans from the Brown Alga Fucus evanescens. Mar Drugs. 2020;18: pubmed publisher
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
Habib S, El Andaloussi A, Elmasry K, Handoussa A, Azab M, Elsawey A, et al. PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani. Infect Immun. 2018;86: pubmed publisher
Hu Z, Chen J, Zhou S, Yang N, Duan S, Zhang Z, et al. Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice. Theranostics. 2017;7:1942-1952 pubmed publisher
Vander Lugt B, Riddell J, Khan A, Hackney J, Lesch J, DeVoss J, et al. Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation. J Cell Biol. 2017;216:779-792 pubmed publisher
Xia L, Plachynta M, Liu T, Xiao X, Song J, Li X, et al. Pro-inflammatory effect of a traditional Chinese medicine formula with potent anti-cancer activity in vitro impedes tumor inhibitory potential in vivo. Mol Clin Oncol. 2016;5:717-723 pubmed publisher
Sulek J, Robinson S, Petrossian A, Zhou S, Goliadze E, Manjili M, et al. Role of Epigenetic Modification and Immunomodulation in a Murine Prostate Cancer Model. Prostate. 2017;77:361-373 pubmed publisher
Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed publisher
Qin Q, Wang Z, Pan P, Cao Z, Xia Q, Tan H, et al. Lung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor. Exp Ther Med. 2014;8:1402-1408 pubmed
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Kim M, Kim T. IgA+ plasma cells in murine intestinal lamina propria as a positive regulator of Treg differentiation. J Leukoc Biol. 2014;95:461-9 pubmed publisher
Sosa R, Murphey C, Ji N, Cardona A, Forsthuber T. The kinetics of myelin antigen uptake by myeloid cells in the central nervous system during experimental autoimmune encephalomyelitis. J Immunol. 2013;191:5848-57 pubmed publisher
Walline C, Deffit S, Wang N, Guindon L, Crotzer V, Liu J, et al. Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology. 2014;141:531-9 pubmed publisher
Chen Y, Chen T, Pai L, Wesoly J, Bluyssen H, Lee C. A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. J Exp Med. 2013;210:2515-22 pubmed publisher
Qin Y, Zhou P, Zhou C, Li J, Gao W. The adipose-derived lineage-negative cells are enriched mesenchymal stem cells and promote limb ischemia recovery in mice. Stem Cells Dev. 2014;23:363-71 pubmed publisher
Baird J, Fox B, Sanders K, Lizotte P, Cubillos Ruiz J, Scarlett U, et al. Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Res. 2013;73:3842-51 pubmed publisher
Cascio J, Haymaker C, Divekar R, Zaghouani S, Khairallah M, Wan X, et al. Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol. 2013;190:6004-14 pubmed publisher
Christy A, Walker M, Hessner M, Brown M. Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE. J Autoimmun. 2013;42:50-61 pubmed publisher
Treviño Villarreal J, Vera Cabrera L, Valero Guillén P, Salinas Carmona M. Nocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in BALB/c mice. Infect Immun. 2012;80:3587-601 pubmed publisher
Matsuo H, Yoshimoto N, Iijima M, Niimi T, Jung J, Jeong S, et al. Engineered hepatitis B virus surface antigen L protein particles for in vivo active targeting of splenic dendritic cells. Int J Nanomedicine. 2012;7:3341-50 pubmed publisher
Rudulier C, Kroeger D, Bretscher P. The activation, by antigen, of naïve TCR transgenic CD4 T cells cultured at physiological, rather than artificially high, frequencies more accurately reflects the in vivo activation of normal numbers of naïve CD4(+) T cells. Cell Immunol. 2012;274:115-20 pubmed publisher
Beamer C, Seaver B, Shepherd D. Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis. Toxicol Sci. 2012;126:554-68 pubmed publisher
LaCasse C, Janikashvili N, Larmonier C, Alizadeh D, Hanke N, Kartchner J, et al. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-?-dependent mechanism. J Immunol. 2011;187:6310-7 pubmed publisher
Duewell P, Kisser U, Heckelsmiller K, Hoves S, Stoitzner P, Koernig S, et al. ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells. J Immunol. 2011;187:55-63 pubmed publisher
Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek Burchardt M, Achilles J, et al. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS ONE. 2011;6:e17314 pubmed publisher
Kozako T, Hirata S, Shimizu Y, Satoh Y, Yoshimitsu M, White Y, et al. Oligomannose-coated liposomes efficiently induce human T-cell leukemia virus-1-specific cytotoxic T lymphocytes without adjuvant. FEBS J. 2011;278:1358-66 pubmed publisher
Wismar R, Brix S, Laerke H, Frøkiaer H. Comparative analysis of a large panel of non-starch polysaccharides reveals structures with selective regulatory properties in dendritic cells. Mol Nutr Food Res. 2011;55:443-54 pubmed publisher
Kozako T, Fukada K, Hirata S, White Y, Harao M, Nishimura Y, et al. Efficient induction of human T-cell leukemia virus-1-specific CTL by chimeric particle without adjuvant as a prophylactic for adult T-cell leukemia. Mol Immunol. 2009;47:606-13 pubmed publisher
Scarlett U, Cubillos Ruiz J, Nesbeth Y, Martinez D, Engle X, Gewirtz A, et al. In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res. 2009;69:7329-37 pubmed publisher
Liu H, Toh W, Lu K, MacAry P, Kemeny D, Cao T. A subpopulation of mesenchymal stromal cells with high osteogenic potential. J Cell Mol Med. 2009;13:2436-47 pubmed publisher
Fortin G, Yurchenko K, Collette C, Rubio M, Villani A, Bitton A, et al. L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. Clin Exp Immunol. 2009;156:161-71 pubmed publisher
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Mielenz D, Vettermann C, Hampel M, Lang C, Avramidou A, Karas M, et al. Lipid rafts associate with intracellular B cell receptors and exhibit a B cell stage-specific protein composition. J Immunol. 2005;174:3508-17 pubmed

product information

Product Type :

Antibody

Product Name :

MHC Class II (I-A) Monoclonal Antibody (NIMR-4), FITC, eBioscience

Catalog # :

11-5322-81

Quantity :

50 µg

Price :

US 122

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test

Species :

Mouse

Clone :

NIMR-4

Isotype :

IgG2b

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test

Aliases :

Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; IAb; I-Abeta; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1