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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FOXP3 Monoclonal Antibody (236A/E7), FITC, eBioscience
catalog :
11-4777-42
quantity :
100 Tests
price :
US 352.00
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
236a/E7
reactivity :
human, mouse, rhesus macaque
application :
flow cytometry
more info or order :
citations: 65
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s7c
Thompson P, Shah A, Ntranos V, Van Gool F, Atkinson M, Bhushan A. Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes. Cell Metab. 2019;29:1045-1060.e10 pubmed publisher
  • flow cytometry; human; loading ...
Stikvoort A, Sundin M, Uzunel M, Gertow J, Sundberg B, Schaffer M, et al. Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?. PLoS ONE. 2016;11:e0154737 pubmed publisher
Salvatore B, Resop R, Gordon B, Epeldegui M, Martinez Maza O, Comin Anduix B, et al. Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals. Cells. 2023;12: pubmed publisher
Teng F, Cui G, Qian L, Zhao L. Changes of T Lymphocyte Subsets in Peripheral Blood of Patients with Intermediate and Advanced Cervical Cancer before and after Nimotuzumab Combined with Chemoradiotherapy. Int Arch Allergy Immunol. 2023;184:85-97 pubmed publisher
van der Woude L, Gorris M, Wortel I, Creemers J, Verrijp K, Monkhorst K, et al. Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination. J Immunother Cancer. 2022;10: pubmed publisher
Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, et al. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022;55:65-81.e9 pubmed publisher
von Schoenfeld A, Bronsert P, Poc M, Fuller A, Filby A, Kraft S, et al. Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol. Int J Mol Sci. 2021;23: pubmed publisher
Phillips D, Matusiak M, Gutierrez B, Bhate S, Barlow G, Jiang S, et al. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma. Nat Commun. 2021;12:6726 pubmed publisher
Tomalka J, Pelletier A, Fourati S, Latif M, Sharma A, Furr K, et al. The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination. Nat Immunol. 2021;22:1294-1305 pubmed publisher
Barbosa A, Martinho O, Nogueira R, Campos J, Lobo L, Pinto H, et al. Increased CD3+, CD8+, or FoxP3+ T Lymphocyte Infiltrations Are Associated with the Pathogenesis of Colorectal Cancer but Not with the Overall Survival of Patients. Biology (Basel). 2021;10: pubmed publisher
Sacrist xe1 n G xf3 mez P, Serrano Somavilla A, Gonz xe1 lez Amaro R, Mart xed nez Hern xe1 ndez R, Marazuela M. Analysis of Expression of Different Histone Deacetylases in Autoimmune Thyroid Disease. J Clin Endocrinol Metab. 2021;106:3213-3227 pubmed publisher
Xydia M, Rahbari R, Ruggiero E, Macaulay I, Tarabichi M, Lohmayer R, et al. Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients. Nat Commun. 2021;12:1119 pubmed publisher
Gómez Aleza C, Nguyen B, Yoldi G, Ciscar M, Barranco A, Hernandez Jimenez E, et al. Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells. Nat Commun. 2020;11:6335 pubmed publisher
Todorova D, Zhang Y, Chen Q, Liu J, He J, Fu X, et al. hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts. EBioMedicine. 2020;62:103120 pubmed publisher
Mi H, Gong C, Sulam J, Fertig E, Szalay A, Jaffee E, et al. Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer. Front Physiol. 2020;11:583333 pubmed publisher
Kanjana K, Chevaisrakul P, Matangkasombut P, Paisooksantivatana K, Lumjiaktase P. Inhibitory activity of FOXP3+ regulatory T cells reveals high specificity for displaying immune tolerance in remission state rheumatoid arthritis. Sci Rep. 2020;10:19789 pubmed publisher
Zhang M, Liu Y, Chen J, Chen L, Meng J, Yang C, et al. Single-cell multi-omics analysis presents the landscape of peripheral blood T-cell subsets in human chronic prostatitis/chronic pelvic pain syndrome. J Cell Mol Med. 2020;24:14099-14109 pubmed publisher
Scherer A, Stephens V, McGivney G, Gutierrez W, Laverty E, Knepper Adrian V, et al. Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Genes (Basel). 2020;11: pubmed publisher
Court A, Le Gatt A, Luz Crawford P, Parra E, Aliaga Tobar V, Batiz L, et al. Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response. EMBO Rep. 2020;21:e48052 pubmed publisher
Gernoux G, Gruntman A, Blackwood M, Zieger M, Flotte T, Mueller C. Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans. Mol Ther. 2020;28:747-757 pubmed publisher
Silva M, Triltsch N, Leis S, Kanchev I, Tan T, Van Peel B, et al. Biomarker recommendation for PD-1/PD-L1 immunotherapy development in pediatric cancer based on digital image analysis of PD-L1 and immune cells. J Pathol Clin Res. 2020;6:124-137 pubmed publisher
Jensen K, Jacobsen M, Schrøder H, Aagaard P, Nielsen J, Jørgensen A, et al. The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training. Arthritis Res Ther. 2019;21:293 pubmed publisher
Triozzi P, Schoenfield L, Plesec T, Saunthararajah Y, Tubbs R, Singh A. Molecular profiling of primary uveal melanomas with tumor-infiltrating lymphocytes. Oncoimmunology. 2019;8:e947169 pubmed publisher
Zhang Y, Du X, Liu M, Tang F, Zhang P, Ai C, et al. Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy. Cell Res. 2019;29:609-627 pubmed publisher
Kim I, Koh C, Jeon I, Shin K, Kang T, Bae E, et al. GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses. Cancer Immunol Res. 2019;7:498-509 pubmed publisher
Roelofsen T, Wefers C, Gorris M, Textor J, Massuger L, de Vries I, et al. Spontaneous Regression of Ovarian Carcinoma After Septic Peritonitis; A Unique Case Report. Front Oncol. 2018;8:562 pubmed publisher
Lopatina T, Favaro E, Grange C, Cedrino M, Ranghino A, Occhipinti S, et al. PDGF enhances the protective effect of adipose stem cell-derived extracellular vesicles in a model of acute hindlimb ischemia. Sci Rep. 2018;8:17458 pubmed publisher
Kelly D, Li X, Kilday C, Feldman S, Clark S, Liu F, et al. Increased circulating regulatory T cells in medicated people with schizophrenia. Psychiatry Res. 2018;269:517-523 pubmed publisher
Whiteoak S, Claridge A, Balendran C, Harris R, Gwiggner M, Bondanese V, et al. MicroRNA-31 Targets Thymic Stromal Lymphopoietin in Mucosal Infiltrated CD4+ T Cells: A Role in Achieving Mucosal Healing in Ulcerative Colitis?. Inflamm Bowel Dis. 2018;24:2377-2385 pubmed publisher
Onion D, Isherwood M, Shridhar N, Xenophontos M, Craze M, Day L, et al. Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer. Oncotarget. 2018;9:1760-1771 pubmed publisher
Terranova Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, et al. HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget. 2017;8:114156-114172 pubmed publisher
Lecciso M, Ocadlikova D, Sangaletti S, Trabanelli S, De Marchi E, Orioli E, et al. ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells. Front Immunol. 2017;8:1918 pubmed publisher
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed publisher
Jiang X, Seo Y, Chang J, Coveler A, Nigjeh E, Pan S, et al. Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment. Oncoimmunology. 2017;6:e1333210 pubmed publisher
Zanin Zhorov A, Weiss J, Trzeciak A, Chen W, Zhang J, Nyuydzefe M, et al. Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10. J Immunol. 2017;198:3809-3814 pubmed publisher
Syed Khaja A, Toor S, El Salhat H, Faour I, Ul Haq N, Ali B, et al. Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment. Oncotarget. 2017;8:33159-33171 pubmed publisher
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
Elias S, Schmidt A, Kannan V, Andersson J, Tegner J. TGF-? Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol. 2016;7:603 pubmed publisher
Weingartner E, Courneya J, Keegan A, Golding A. A novel method for assaying human regulatory T cell direct suppression of B cell effector function. J Immunol Methods. 2017;441:1-7 pubmed publisher
Kovacsovics Bankowski M, Kelley T, Efimova O, Kim S, Wilson A, Swierczek S, et al. Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2V617F allelic burden. Exp Hematol Oncol. 2015;5:28 pubmed
Miyan M, Schmidt Mende J, Kiessling R, Poschke I, de Boniface J. Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer. J Transl Med. 2016;14:227 pubmed publisher
Liang D, Hou Y, Luo L, Ao L. Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. Int J Mol Med. 2016;38:131-8 pubmed publisher
Ghosh S, Taylor A, Chin M, Huang H, Conery A, Mertz J, et al. Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition. J Biol Chem. 2016;291:13014-27 pubmed publisher
Macdonald K, Hoeppli R, Huang Q, Gillies J, Luciani D, Orban P, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest. 2016;126:1413-24 pubmed publisher
Thompson E, Taube J, Elwood H, Sharma R, Meeker A, Warzecha H, et al. The immune microenvironment of breast ductal carcinoma in situ. Mod Pathol. 2016;29:249-58 pubmed publisher
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
Katawa G, Layland L, Debrah A, von Horn C, Batsa L, Kwarteng A, et al. Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells. PLoS Negl Trop Dis. 2015;9:e3414 pubmed publisher
Skogberg G, Lundberg V, Lindgren S, Gudmundsdottir J, Sandström K, Kämpe O, et al. Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype. J Immunol. 2014;193:2187-95 pubmed publisher
Ye S, Li Z, Luo D, Huang B, Chen Y, Zhang X, et al. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014;5:5439-52 pubmed
Schmidt H, Ge Y, Hartmann F, Conrad H, Klug F, Nittel S, et al. HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. Oncoimmunology. 2013;2:e24962 pubmed
Dokić J, Tomic S, Markovic M, Milosavljević P, Colic M. Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells. Eur J Immunol. 2013;43:1862-72 pubmed publisher
Tuxun T, Wang J, Lin R, Shan J, Tai Q, Li T, et al. Th17/Treg imbalance in patients with liver cystic echinococcosis. Parasite Immunol. 2012;34:520-7 pubmed publisher
Sucher R, Fischler K, Oberhuber R, Kronberger I, Margreiter C, Ollinger R, et al. IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival. J Immunol. 2012;188:37-46 pubmed publisher
Mohebtash M, Tsang K, Madan R, Huen N, Poole D, Jochems C, et al. A pilot study of MUC-1/CEA/TRICOM poxviral-based vaccine in patients with metastatic breast and ovarian cancer. Clin Cancer Res. 2011;17:7164-73 pubmed publisher
Green A, Mattila J, Bigbee C, Bongers K, Lin P, Flynn J. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. J Infect Dis. 2010;202:533-41 pubmed publisher
Akimova T, Ge G, Golovina T, Mikheeva T, Wang L, Riley J, et al. Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs. Clin Immunol. 2010;136:348-63 pubmed publisher
Law J, Hirschkorn D, Owen R, Biswas H, Norris P, Lanteri M. The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells. Cytometry A. 2009;75:1040-50 pubmed publisher
Kasprzycka M, Zhang Q, Witkiewicz A, Marzec M, Potoczek M, Liu X, et al. Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes. J Immunol. 2008;181:2506-12 pubmed
Estes J, Gordon S, Zeng M, Chahroudi A, Dunham R, Staprans S, et al. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J Immunol. 2008;180:6798-807 pubmed
Qin S, Sui Y, Soloff A, Junecko B, Kirschner D, Murphey Corb M, et al. Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection. J Immunol. 2008;180:5530-6 pubmed
Wolf D, Wolf A, Rumpold H, Fiegl H, Zeimet A, Muller Holzner E, et al. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res. 2005;11:8326-31 pubmed
Ahmadzadeh M, Rosenberg S. IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood. 2006;107:2409-14 pubmed
Roncador G, Garcia J, Maestre L, Lucas E, Menarguez J, Ohshima K, et al. FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma. Leukemia. 2005;19:2247-53 pubmed
Roncador G, Brown P, Maestre L, Hue S, Martinez Torrecuadrada J, Ling K, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol. 2005;35:1681-91 pubmed
Alvaro T, Lejeune M, Salvadó M, Bosch R, Garcia J, Jaén J, et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res. 2005;11:1467-73 pubmed
product information
Product Type :
Antibody
Product Name :
FOXP3 Monoclonal Antibody (236A/E7), FITC, eBioscience
Catalog # :
11-4777-42
Quantity :
100 Tests
Price :
US 352.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Non-human primate, Rhesus Monkey
Applications :
Flow Cytometry: 5 µL (0.25 µg)/test
Species :
Human, Non-human primate, Rhesus Monkey
Clone :
236A/E7
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.25 µg)/test
Aliases :
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA