CD183 (CXCR3) Monoclonal Antibody (CXCR3-173), FITC, eBioscience™ | Invitrogen 11-1831-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD183 (CXCR3) Monoclonal Antibody (CXCR3-173), FITC, eBioscience™

catalog :

11-1831-82

quantity :

100 µg

price :

US 348

clonality :

monoclonal

host :

hamsters

conjugate :

FITC

clone name :

CXCR3-173

reactivity :

African green monkey, mouse

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 40

Published Application/Species/Sample/Dilution	Reference
flow cytometry; African green monkey; loading ...; fig s11a immunocytochemistry; African green monkey; loading ...; fig 7g	Ferrando Martinez S, Moysi E, Pegu A, Andrews S, Nganou Makamdop K, Ambrozak D, et al. Accumulation of follicular CD8+ T cells in pathogenic SIV infection. J Clin Invest. 2018;128:2089-2103 pubmed publisher
	Vonderhaar E, Barnekow N, McAllister D, McOlash L, Eid M, Riese M, et al. STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:41-58 pubmed publisher
	Chen J, Chen Y, Shi Y, Ding S, Shen L, Wang R, et al. VX-765 reduces neuroinflammation after spinal cord injury in mice. Neural Regen Res. 2021;16:1836-1847 pubmed publisher
	Eslamizar L, Petrovas C, Leggat D, Furr K, Lifton M, Levine G, et al. Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center. NPJ Vaccines. 2021;6:15 pubmed publisher
	Gu M, Zhou X, Sohn J, Zhu L, Jie Z, Yang J, et al. NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nat Immunol. 2021;22:193-204 pubmed publisher
	Ferrere G, Tidjani Alou M, Liu P, Goubet A, Fidelle M, Kepp O, et al. Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade. JCI Insight. 2021;6: pubmed publisher
	Zhao K, Tian Y, Wang J, Chen C, Pan B, Yan Z, et al. Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2. Biomed Res Int. 2020;2020:7619849 pubmed publisher
	Wang Y, Wang Q, Wang B, Gu Y, Yu H, Yang W, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells. Cell Death Dis. 2020;11:1024 pubmed publisher
	Nguyen H, Ticer T, Bastian D, Kuril S, Li H, Du H, et al. Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease. Cell Rep. 2020;33:108316 pubmed publisher
	Van Braeckel Budimir N, Varga S, Badovinac V, Harty J. Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Rep. 2018;24:3374-3382.e3 pubmed publisher
	García Nores G, Ly C, Cuzzone D, Kataru R, Hespe G, Torrisi J, et al. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema. Nat Commun. 2018;9:1970 pubmed publisher
	Lindenstrøm T, Moguche A, Damborg M, Agger E, URDAHL K, Andersen P. T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties. EBioMedicine. 2018;27:27-39 pubmed publisher
	Levine A, Mendoza A, Hemmers S, Moltedo B, Niec R, Schizas M, et al. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017;546:421-425 pubmed publisher
	Young C, Rorke E, Adhikary G, Xu W, Eckert R. Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype. Cell Death Dis. 2017;8:e2840 pubmed publisher
	Vladimer G, Snijder B, Krall N, Bigenzahn J, Huber K, Lardeau C, et al. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017;13:681-690 pubmed publisher
	Dende C, Meena J, Nagarajan P, Panda A, Rangarajan P, Padmanaban G. Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria. Sci Rep. 2015;5:12671 pubmed publisher
	Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, et al. Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy. 2014;10:1301-15 pubmed publisher
	Roebrock K, Sunderkotter C, Münck N, Wolf M, Nippe N, Barczyk K, et al. Epidermal expression of I-TAC (Cxcl11) instructs adaptive Th2-type immunity. FASEB J. 2014;28:1724-34 pubmed publisher
	Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein C, et al. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS ONE. 2013;8:e75737 pubmed publisher
	Peperzak V, Veraar E, Xiao Y, Babala N, Thiadens K, Brugmans M, et al. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol. 2013;191:3025-36 pubmed publisher
	Radulovic K, Rossini V, Manta C, Holzmann K, Kestler H, Niess J. The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. PLoS ONE. 2013;8:e65413 pubmed publisher
	Breser M, Motrich R, Sanchez L, Mackern Oberti J, Rivero V. Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of chronic prostatitis/chronic pelvic pain syndrome. J Immunol. 2013;190:3121-33 pubmed publisher
	Metcalf T, Baxter V, Nilaratanakul V, Griffin D. Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis. J Virol. 2013;87:2420-9 pubmed publisher
	Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, et al. Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal Immunol. 2013;6:847-56 pubmed publisher
	Herzig D, Guo Y, Fang G, Toliver Kinsky T, Sherwood E. Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis. Crit Care. 2012;16:R168 pubmed publisher
	Piehler D, Grahnert A, Eschke M, Richter T, Kohler G, Stenzel W, et al. T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Mucosal Immunol. 2013;6:405-14 pubmed publisher
	Choi J, Ziga E, Ritchey J, Collins L, Prior J, Cooper M, et al. IFN?R signaling mediates alloreactive T-cell trafficking and GVHD. Blood. 2012;120:4093-103 pubmed publisher
	Domingos Pereira S, Decrausaz L, DerrÃ© L, Bobst M, Romero P, Schiller J, et al. Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol. 2013;6:393-404 pubmed publisher
	Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
	Sharma A, Chen Q, Nguyen T, Yu Q, Sen J. T cell factor-1 and Î²-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188:3859-68 pubmed publisher
	Wilson J, Pack C, Lin E, Frost E, Albrecht J, Hadley A, et al. CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion. J Immunol. 2012;188:4340-8 pubmed publisher
	Herzig D, Driver B, Fang G, Toliver Kinsky T, Shute E, Sherwood E. Regulation of lymphocyte trafficking by CXC chemokine receptor 3 during septic shock. Am J Respir Crit Care Med. 2012;185:291-300 pubmed publisher
	Gonzaga R, Matzinger P, Perez Diez A. Resident peritoneal NK cells. J Immunol. 2011;187:6235-42 pubmed publisher
	Yoshizawa K, Nakajima S, Notake T, Miyagawa S, Hida S, Taki S. IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice. J Immunol. 2011;187:5162-9 pubmed publisher
	Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol. 2011;187:4581-8 pubmed publisher
	Hayakawa Y, Sato Matsushita M, Takeda K, Iwakura Y, Tahara H, Irimura T. Early activation and interferon-? production of tumor-infiltrating mature CD27 high natural killer cells. Cancer Sci. 2011;102:1967-71 pubmed publisher
	Qu Y, Taylor J, Bose A, Storkus W. Therapeutic effectiveness of intratumorally delivered dendritic cells engineered to express the pro-inflammatory cytokine, interleukin (IL)-32. Cancer Gene Ther. 2011;18:663-73 pubmed publisher
	Haworth O, Cernadas M, Levy B. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. J Immunol. 2011;186:6129-35 pubmed publisher
	Sharma R, Sung S, Abaya C, Ju A, Fu S, Ju S. IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation. J Immunol. 2009;183:1065-73 pubmed publisher
	Uppaluri R, Sheehan K, Wang L, Bui J, Brotman J, Lu B, et al. Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody. Transplantation. 2008;86:137-47 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD183 (CXCR3) Monoclonal Antibody (CXCR3-173), FITC, eBioscience™

Catalog # :

11-1831-82

Quantity :

100 µg

Price :

US 348

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

CXCR3-173

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

an; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; Cmkar3; CXC; C-X-C chemokine receptor type 3; CXC motif chemokine; C-X-C motif chemokine receptor 3; CXCR3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP10; IP10 receptor; IP-10 receptor; IP10-R; Mig receptor; MigR; Mig-R

more info or order :

Invitrogen product webpage