product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD133 (Prominin-1) Monoclonal Antibody (13A4), FITC, eBioscience
catalog :
11-1331-82
quantity :
100 ug
price :
US 369.00
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
13A4
reactivity :
mouse, dogs
application :
flow cytometry
more info or order :
citations: 64
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 3d
Barros Silva J, Linn D, Steiner I, Guo G, Ali A, Pakula H, et al. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep. 2018;25:3504-3518.e6 pubmed publisher
  • flow cytometry; mouse; fig 7
Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, et al. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol. 2015;17:971-983 pubmed publisher
Mkhobongo B, Chandran R, Abrahamse H. In Vitro Photodynamic Treatment Modality for A375 Melanoma Cell Line Using a Sulphonated Aluminum Phthalocyanine Chloride-Photosensitizer-Gold Nanoparticle Conjugate. Pharmaceutics. 2022;14: pubmed publisher
Serra C, Liu H, Qian J, Mori M, LU J, Cardoso W. Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium. iScience. 2022;25:104751 pubmed publisher
Liu X, Rulina A, Choi M, Pedersen L, Lepland J, Takle S, et al. C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer. Nat Commun. 2022;13:69 pubmed publisher
Velloso F, Kumari E, Buono K, Frondelli M, Levison S. Analyzing mouse neural stem cell and progenitor cell proliferation using EdU incorporation and multicolor flow cytometry. STAR Protoc. 2022;3:101065 pubmed publisher
Belenguer G, Duart Abadia P, Domingo Muelas A, Morante Redolat J, Farinas I. Cell population analysis of the adult murine subependymal neurogenic lineage by flow cytometry. STAR Protoc. 2021;2:100425 pubmed publisher
Yarmishyn A, Yang Y, Lu K, Chen Y, Chien Y, Chou S, et al. Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1. Cancer Cell Int. 2020;20:597 pubmed publisher
Liu H, Liu C, Qu Y. The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells. Bosn J Basic Med Sci. 2021;21:313-322 pubmed publisher
Gagniac L, Rusidzé M, Boudou F, Cagnet S, Adlanmerini M, Jeannot P, et al. Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium. Development. 2020;147: pubmed publisher
HWANG C, Marini S, Huber A, Stepien D, Sorkin M, Loder S, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36 pubmed publisher
Zurkirchen L, Varum S, Giger S, Klug A, Häusel J, Bossart R, et al. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019;10:2192 pubmed publisher
Wang X, Zhao Z, Zhang H, Hou J, Feng W, Zhang M, et al. Simultaneous isolation of mesenchymal stem cells and endothelial progenitor cells derived from murine bone marrow. Exp Ther Med. 2018;16:5171-5177 pubmed publisher
Sheng Z, Ju C, Li B, Chen Z, Pan X, Yan G, et al. TWEAK promotes endothelial progenitor cell vasculogenesis to alleviate acute myocardial infarction via the Fn14-NF-κB signaling pathway. Exp Ther Med. 2018;16:4019-4029 pubmed publisher
Singhal M, Liu X, Inverso D, Jiang K, Dai J, He H, et al. Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med. 2018;215:2497-2508 pubmed publisher
Edamakanti C, Do J, Didonna A, Martina M, Opal P. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018;128:2252-2265 pubmed publisher
Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, et al. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells. Cancer Sci. 2017;: pubmed publisher
Albert M, Kalebic N, Florio M, Lakshmanaperumal N, Haffner C, Brandl H, et al. Epigenome profiling and editing of neocortical progenitor cells during development. EMBO J. 2017;36:2642-2658 pubmed publisher
Yu L, Chen S, Luo N, He S. The C-terminus domain of the hepatitis B virus x protein stimulates the proliferation of mouse foetal hepatic progenitor cells, although it is not required for the formation of spheroids. Int J Mol Med. 2017;40:400-410 pubmed publisher
Shang Z, Xu Y, Liang W, Liang K, Hu X, Wang L, et al. Isolation of cancer progenitor cells from cancer stem cells in gastric cancer. Mol Med Rep. 2017;15:3637-3643 pubmed publisher
Weng L, Hu X, Kumar B, García M, Todorov I, Jung X, et al. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Sci Rep. 2016;6:38632 pubmed publisher
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher
Le Coz V, Zhu C, Devocelle A, Vazquez A, Boucheix C, Azzi S, et al. IGF-1 contributes to the expansion of melanoma-initiating cells through an epithelial-mesenchymal transition process. Oncotarget. 2016;7:82511-82527 pubmed publisher
Atapattu L, Saha N, Chheang C, Eissman M, Xu K, Vail M, et al. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med. 2016;213:1741-57 pubmed publisher
Wang K, Zhou X, Wu M, Kang F, Wang Z, Zhu Y. Role of CD133+ cells in tongue squamous carcinomas: Characteristics of 'stemness' in vivo and in vitro. Oncol Lett. 2016;12:863-870 pubmed
Park J, Park J, Park D, Kim D, Kim H. Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. Stem Cells. 2016;34:1177-87 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Siavashi V, Nassiri S, Rahbarghazi R, Vafaei R, Sariri R. ECM-Dependence of Endothelial Progenitor Cell Features. J Cell Biochem. 2016;117:1934-46 pubmed publisher
Luo Y, Coskun V, Liang A, Yu J, Cheng L, Ge W, et al. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. Cell. 2015;161:1175-1186 pubmed publisher
Zechner D, Radecke T, Amme J, Bürtin F, Albert A, Partecke L, et al. Impact of diabetes type II and chronic inflammation on pancreatic cancer. BMC Cancer. 2015;15:51 pubmed publisher
Cuevas E, Rybak Wolf A, Rohde A, Nguyen D, Wulczyn F. Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20 pubmed publisher
Das J, Voelkel N, Felty Q. ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: its implication for understanding microvascular diseases. Microvasc Res. 2015;98:126-38 pubmed publisher
Miller T, Wang J, Sukhdeo K, Horbinski C, Tesar P, Wechsler Reya R, et al. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS ONE. 2014;9:e114433 pubmed publisher
Liu B, Yang L, Lu X, Song X, Li X, Chen G, et al. Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels. J Am Soc Nephrol. 2015;26:1576-87 pubmed publisher
Ubil E, Duan J, Pillai I, Rosa Garrido M, Wu Y, Bargiacchi F, et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014;514:585-90 pubmed publisher
Quante T, Wegwitz F, Abe J, Rossi A, Deppert W, Bohn W. Aberrant Proliferation of Differentiating Alveolar Cells Induces Hyperplasia in Resting Mammary Glands of SV40-TAg Transgenic Mice. Front Oncol. 2014;4:168 pubmed publisher
Lua I, James D, Wang J, WANG K, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014;60:311-22 pubmed publisher
Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, et al. Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development. PLoS ONE. 2013;8:e75222 pubmed publisher
Adorno M, Sikandar S, Mitra S, Kuo A, Nicolis Di Robilant B, Haro Acosta V, et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013;501:380-4 pubmed publisher
Tasso R, Ulivi V, Reverberi D, Lo Sicco C, Descalzi F, Cancedda R. In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche. Stem Cells Dev. 2013;22:3178-91 pubmed publisher
Main H, Radenkovic J, Jin S, Lendahl U, Andersson E. Notch signaling maintains neural rosette polarity. PLoS ONE. 2013;8:e62959 pubmed publisher
Krelin Y, Berkovich L, Amit M, Gil Z. Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model. PLoS ONE. 2013;8:e62124 pubmed publisher
Roehrich M, Spicher A, Milano G, Vassalli G. Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity. Biomed Res Int. 2013;2013:503047 pubmed publisher
Buono K, Vadlamuri D, Gan Q, Levison S. Leukemia inhibitory factor is essential for subventricular zone neural stem cell and progenitor homeostasis as revealed by a novel flow cytometric analysis. Dev Neurosci. 2012;34:449-62 pubmed publisher
Peng X, Liu T, Wang Y, Yan Q, Jin H, Li L, et al. Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells. J Transl Med. 2012;10:196 pubmed publisher
Agrawal V, Siu B, Chao H, Hirschi K, Raborn E, Johnson S, et al. Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue Eng Part A. 2012;18:1454-63 pubmed publisher
Alfaro Cervello C, Soriano Navarro M, Mirzadeh Z, Alvarez Buylla A, Garcia Verdugo J. Biciliated ependymal cell proliferation contributes to spinal cord growth. J Comp Neurol. 2012;520:3528-52 pubmed publisher
Morimoto H, Lee J, Tanaka T, Ishii K, Toyokuni S, Kanatsu Shinohara M, et al. In vitro transformation of mouse testis cells by oncogene transfection. Biol Reprod. 2012;86:148, 1-11 pubmed publisher
Stoll E, Habibi B, Mikheev A, Lasiene J, Massey S, Swanson K, et al. Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone. Stem Cells. 2011;29:2005-17 pubmed publisher
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, et al. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011;208:949-60 pubmed publisher
Yang Y, Ahn Y, Gibbons D, Zang Y, Lin W, Thilaganathan N, et al. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest. 2011;121:1373-85 pubmed publisher
Anderson L, Boulanger C, Smith G, Carmeliet P, Watson C. Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland. Dev Dyn. 2011;240:674-81 pubmed publisher
Kim M, Koh Y, Kim K, Koh B, Nam D, Alitalo K, et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 2010;70:10411-21 pubmed publisher
Pfenninger C, Steinhoff C, Hertwig F, Nuber U. Prospectively isolated CD133/CD24-positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-term in vitro self-renewal and in vivo gene expression. Glia. 2011;59:68-81 pubmed publisher
Burger P, Gupta R, Xiong X, ONTIVEROS C, Salm S, Moscatelli D, et al. High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells. 2009;27:2220-8 pubmed publisher
Santisteban M, Reiman J, Asiedu M, Behrens M, Nassar A, Kalli K, et al. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res. 2009;69:2887-95 pubmed publisher
Zhu L, Gibson P, Currle D, Tong Y, Richardson R, Bayazitov I, et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009;457:603-7 pubmed publisher
Katebi M, Soleimani M, Cronstein B. Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development. J Leukoc Biol. 2009;85:438-44 pubmed publisher
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher
Pfenninger C, Roschupkina T, Hertwig F, Kottwitz D, Englund E, Bengzon J, et al. CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells. Cancer Res. 2007;67:5727-36 pubmed
Nakano M, Satoh K, Fukumoto Y, Ito Y, Kagaya Y, Ishii N, et al. Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res. 2007;100:662-9 pubmed
Sugiyama T, Rodriguez R, McLean G, Kim S. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A. 2007;104:175-80 pubmed
Lamerato Kozicki A, Helm K, Jubala C, Cutter G, Modiano J. Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol. 2006;34:870-8 pubmed
Lee A, Kessler J, Read T, Kaiser C, Corbeil D, Huttner W, et al. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005;8:723-9 pubmed
product information
Product Type :
Antibody
Product Name :
CD133 (Prominin-1) Monoclonal Antibody (13A4), FITC, eBioscience
Catalog # :
11-1331-82
Quantity :
100 ug
Price :
US 369.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Canine, Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Canine, Mouse
Clone :
13A4
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
The CD133 (AC133) antigen is a 97 kDa glycoprotein, with 5 transmembrane domains, that shows up as a 120 kDa band on protein gels due to glycosylation. CD133 is a cell surface marker expressed by immature hematopoietic stem cells but not mature blood cells. In addition to hematopoietic stem and progenitor cells, CD133 has been found to be a marker for other stem and progenitor cells including neural and embryonic stem cells. CD133 has been shown to be expressed in cancers, including some leukemias and brain tumors, that may be derived from stem cells. Low level expression could also be detected in the kidney, pancreas, placenta, and fetal liver. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of the CD133 gene is also associated with several types of cancer. CD133 is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner, and multiple transcript variants encoding different isoforms have been found.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
4932416E19Rik; AC133; Antigen AC133; antigen AC133 homolog; antigen CD133; CD107b; CD133; CORD12; fudenine; hematopoietic stem cell antigen; hProminin; Lamp II; Lamp2; LAMP-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-96; LGP-B; Mac3; MCDR2; MSTP061; Prom; PROM1; Prom-1; prominin 1; prominin 1.s1; Prominin1; prominin-1; prominin-1.s2; prominin-like 1; prominin-like protein 1; PROML1; RP41; STGD4
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA