product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD127 Monoclonal Antibody (A7R34), FITC, eBioscience
catalog :
11-1271-81
quantity :
50 ug
price :
US 120.00
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
A7R34
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 228
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 5d
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  • flow cytometry; mouse; fig 3
Braun J, Meixner A, Brachner A, Foisner R. The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis. PLoS ONE. 2016;11:e0152278 pubmed publisher
  • flow cytometry; mouse; fig 5a
Wu X, Satpathy A, Kc W, Liu P, Murphy T, Murphy K. Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PLoS ONE. 2013;8:e64800 pubmed publisher
Cui J, Wang H, Liu S, Zhao Y. New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral Hemorrhage. J Inflamm Res. 2024;17:399-415 pubmed publisher
Dar A, Kim D, Gordon S, Klinzing K, Rosen S, Guha I, et al. c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity. Nat Commun. 2023;14:7098 pubmed publisher
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Lee Y, Kim S, Jeong H, Kim K, Jeon D, Cho Y, et al. Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium-Induced Colitis. Cell Mol Gastroenterol Hepatol. 2023;16:411-429 pubmed publisher
Jakob M, Spari D, S xe0 nchez Taltavull D, Salm L, Yilmaz B, Doucet Ladev xe8 ze R, et al. ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery. Cell Rep. 2023;42:112269 pubmed publisher
Zhang Y, Liu T, Deng Z, Fang W, Zhang X, Zhang S, et al. Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils. Adv Sci (Weinh). 2023;10:e2206958 pubmed publisher
Cannons J, Villarino A, Kapnick S, Preite S, Shih H, Gomez Rodriguez J, et al. PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory. Cell Rep. 2021;37:109804 pubmed publisher
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Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018;9:1241 pubmed publisher
Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, et al. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Immunity. 2018;48:258-270.e5 pubmed publisher
Luo B, Chen K, Feng Q, Xiao W, Ma D, Yang H, et al. The interplay of BMP4 and IL?7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia?reperfusion. Int J Mol Med. 2018;41:2640-2650 pubmed publisher
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Puleston D, Zhang H, Powell T, Lipina E, Sims S, Panse I, et al. Autophagy is a critical regulator of memory CD8(+) T cell formation. elife. 2014;3: pubmed publisher
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Mollo S, Zajac A, Harrington L. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol. 2013;191:6052-9 pubmed publisher
Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, et al. IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Lett. 2013;156:82-93 pubmed publisher
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Li G, Yang Q, Zhu Y, Wang H, Chen X, Zhang X, et al. T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. PLoS ONE. 2013;8:e67401 pubmed publisher
Bhadra R, Cobb D, Khan I. Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population. Infect Immun. 2013;81:3414-25 pubmed publisher
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Chang P, Lee S, Hu X, Davey G, Duan G, Cho J, et al. Breakdown in repression of IFN-? mRNA leads to accumulation of self-reactive effector CD8+ T cells. J Immunol. 2012;189:701-10 pubmed publisher
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Pham N, Badovinac V, Harty J. Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice. Eur J Immunol. 2012;42:1488-99 pubmed publisher
Kim G, Ligons D, Hong C, Luckey M, Keller H, Tai X, et al. An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis. J Immunol. 2012;188:5859-66 pubmed publisher
Pham N, Badovinac V, Harty J. Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo. Front Immunol. 2011;2:4 pubmed publisher
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Sharma A, Chen Q, Nguyen T, Yu Q, Sen J. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188:3859-68 pubmed publisher
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Mathieu M, Cotta Grand N, Daudelin J, Boulet S, Lapointe R, Labrecque N. CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells. PLoS ONE. 2012;7:e30139 pubmed publisher
Iseki M, Omori Miyake M, Xu W, Sun X, Takaki S, Rawlings D, et al. Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4. Int Immunol. 2012;24:183-95 pubmed publisher
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Kim S, Han S, Withers D, Gaspal F, Bae J, Baik S, et al. CD117? CD3? CD56? OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues. Eur J Immunol. 2011;41:1563-72 pubmed publisher
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Yeo C, Fearon D. T-bet-mediated differentiation of the activated CD8+ T cell. Eur J Immunol. 2011;41:60-6 pubmed publisher
Divekar A, Dubey S, Gangalum P, Singh R. Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu. J Immunol. 2011;186:924-30 pubmed publisher
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Obar J, Lefrancois L. Early signals during CD8 T cell priming regulate the generation of central memory cells. J Immunol. 2010;185:263-72 pubmed publisher
Furmanov K, Elnekave M, Lehmann D, Clausen B, Kotton D, Hovav A. The role of skin-derived dendritic cells in CD8+ T cell priming following immunization with lentivectors. J Immunol. 2010;184:4889-97 pubmed publisher
Bivas Benita M, Bar L, Gillard G, Kaufman D, Simmons N, Hovav A, et al. Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization. J Virol. 2010;84:5764-74 pubmed publisher
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Hirata Y, Hamanaka S, Onodera M. Transactivation of the dopamine receptor 3 gene by a single provirus integration results in development of B-cell lymphoma in transgenic mice generated from retrovirally transduced embryonic stem cells. Blood. 2010;115:3930-8 pubmed publisher
Chappaz S, Finke D. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol. 2010;184:3562-9 pubmed publisher
Welner R, Esplin B, Garrett K, Pelayo R, Luche H, Fehling H, et al. Asynchronous RAG-1 expression during B lymphopoiesis. J Immunol. 2009;183:7768-77 pubmed publisher
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Onai N, Manz M, Schmid M. Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. Methods Mol Biol. 2010;595:195-203 pubmed publisher
Rai D, Pham N, Harty J, Badovinac V. Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts. J Immunol. 2009;183:7672-81 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD127 Monoclonal Antibody (A7R34), FITC, eBioscience
Catalog # :
11-1271-81
Quantity :
50 ug
Price :
US 120.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test
Species :
Mouse
Clone :
A7R34
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test
Aliases :
CD127; CD127 antigen; CDW127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R a; IL 7Ra; IL 7Ra; IL7 receptor; IL-7 receptor alpha chain; IL7 receptor subunit alpha; IL-7 receptor subunit alpha; IL7R; IL-7R; IL7R a; IL7R alpha; IL7R subunit alpha; IL-7R subunit alpha; IL7R a; IL7RA; IL-7RA; IL-7Ralpha; IL-7R-alpha; IL7Ra; ILRA; interleukin 7 receptor; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin7 receptor subunit alpha; interleukin-7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA