product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD117 (c-Kit) Monoclonal Antibody (2B8), FITC, eBioscience
catalog :
11-1171-85
quantity :
500 ug
price :
US 354.00
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
2B8
reactivity :
mouse, pigs
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 96
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig 3a
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Fu Z, Dean J, Xiong L, Dougherty M, Oliff K, Chen Z, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021;12:4462 pubmed publisher
Cardenas R, Gonzalez R, Sanchez E, Ramos M, Cardenas E, Rodarte A, et al. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis. J Biol Chem. 2021;296:100268 pubmed publisher
Furuyama S, Wu Q, Varnum Finney B, Sandstrom R, Meuleman W, Stamatoyannopoulos J, et al. Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments. Stem Cell Reports. 2021;16:717-726 pubmed publisher
van den Berk P, Lancini C, Company C, Serresi M, Sanchez Bailon M, Hulsman D, et al. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. Cell Rep. 2020;33:108533 pubmed publisher
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Forte D, Garcia Fernandez M, Sanchez Aguilera A, Stavropoulou V, Fielding C, Martin Perez D, et al. Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metab. 2020;32:829-843.e9 pubmed publisher
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Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, et al. Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Cancer Cell. 2020;38:79-96.e11 pubmed publisher
Liu C, Liu X, Wang Y, Deng Z, Liu T, Sukhova G, et al. Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms. Hypertension. 2020;76:87-100 pubmed publisher
Zheng Y, Wang N, Wang S, Yang B, Situ H, Zhong L, et al. XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling. Cell Commun Signal. 2020;18:48 pubmed publisher
Majorini M, Cancila V, Rigoni A, Botti L, Dugo M, Triulzi T, et al. Infiltrating Mast Cell-Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype. Cancer Res. 2020;80:2311-2324 pubmed publisher
Venables T, Griffith A, DeAraujo A, Petrie H. Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration. Nat Commun. 2019;10:4402 pubmed publisher
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Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, et al. Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. Stem Cell Reports. 2018;11:988-997 pubmed publisher
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed publisher
Potůčková L, Dráberová L, Hálová I, Paulenda T, Draber P. Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein. Front Immunol. 2018;9:1771 pubmed publisher
Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth B, et al. The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. elife. 2018;7: pubmed publisher
Kim S, Knight D, Jones L, Vervoort S, Ng A, Seymour J, et al. JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias. Genes Dev. 2018;32:849-864 pubmed publisher
Vasiliauskaite L, Berrens R, Ivanova I, Carrieri C, Reik W, Enright A, et al. Defective germline reprogramming rewires the spermatogonial transcriptome. Nat Struct Mol Biol. 2018;25:394-404 pubmed publisher
Bergiers I, Andrews T, Vargel Bölükbaşı Ö, Buness A, Janosz E, Lopez Anguita N, et al. Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis. elife. 2018;7: pubmed publisher
Friedman B, Whitney M, Savariar E, Caneda C, Steinbach P, Xiong Q, et al. A thrombin receptor - derived imaging agent detects subclinical arthritis in mice. Arthritis Rheumatol. 2017;: pubmed publisher
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T. Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep. 2017;7:12475 pubmed publisher
Hewitt K, Katsumura K, Matson D, Devadas P, Tanimura N, Hebert A, et al. GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Dev Cell. 2017;42:213-225.e4 pubmed publisher
Hérault A, Binnewies M, Leong S, Calero Nieto F, Zhang S, Kang Y, et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544:53-58 pubmed publisher
Ryu D, Lim J, Lee S, Park G, Min C. Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis. Immune Netw. 2016;16:358-365 pubmed publisher
Strandmark J, Steinfelder S, Berek C, Kühl A, Rausch S, Hartmann S. Eosinophils are required to suppress Th2 responses in Peyer's patches during intestinal infection by nematodes. Mucosal Immunol. 2017;10:661-672 pubmed publisher
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016;126:4537-4553 pubmed publisher
Bellio M, Rodrigues C, Landin A, Hatzistergos K, Kuznetsov J, Florea V, et al. Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration. Am J Physiol Heart Circ Physiol. 2016;311:H1509-H1519 pubmed publisher
Wysoczynski M, Dassanayaka S, Zafir A, Ghafghazi S, Long B, Noble C, et al. A New Method to Stabilize C-Kit Expression in Reparative Cardiac Mesenchymal Cells. Front Cell Dev Biol. 2016;4:78 pubmed publisher
Shi Y, Wu W, Chai Q, Li Q, Hou Y, Xia H, et al. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun. 2016;7:12369 pubmed publisher
Mian Y, Zeleznik Le N. The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1. Leuk Res. 2016;46:51-60 pubmed publisher
Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
Bambousková M, Polakovičová I, Hálová I, Goel G, Dráberová L, Bugajev V, et al. New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. Mol Cell Biol. 2016;36:1366-82 pubmed publisher
Crisan M, Solaimani Kartalaei P, Neagu A, Karkanpouna S, Yamada Inagawa T, Purini C, et al. BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo. Stem Cell Reports. 2016;6:383-95 pubmed publisher
Thoms J, Knezevic K, Liu J, Glaros E, Thai T, Qiao Q, et al. Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr. Mol Cell Biol. 2016;36:1222-36 pubmed publisher
Johnson K, Kong G, Gao X, Chang Y, Hewitt K, Sanalkumar R, et al. Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv. 2015;1:e1500503 pubmed publisher
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Acar M, Kocherlakota K, Murphy M, Peyer J, Oguro H, Inra C, et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature. 2015;526:126-30 pubmed publisher
Zoch A, Mayerl S, Schulz A, Greither T, Frappart L, Rübsam J, et al. Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation. PLoS ONE. 2015;10:e0129151 pubmed publisher
Suzuki M, Morita R, Hirata Y, Shichita T, Yoshimura A. Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells. J Immunol. 2015;195:1273-81 pubmed publisher
Giannou A, Marazioti A, Spella M, Kanellakis N, Apostolopoulou H, Psallidas I, et al. Mast cells mediate malignant pleural effusion formation. J Clin Invest. 2015;125:2317-34 pubmed publisher
Song N, Gao L, Qiu H, Huang C, Cheng H, Zhou H, et al. Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant. Int J Mol Med. 2015;36:139-49 pubmed publisher
Hadland B, Varnum Finney B, Poulos M, Moon R, Butler J, Rafii S, et al. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest. 2015;125:2032-45 pubmed publisher
Rodriguez A, Plascencia Villa G, Witt C, Yu J, José Yacamán M, Chambers J, et al. Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. Cell Immunol. 2015;295:83-91 pubmed publisher
Danelli L, Frossi B, Gri G, Mion F, Guarnotta C, Bongiovanni L, et al. Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment. Cancer Immunol Res. 2015;3:85-95 pubmed publisher
Hodgkinson C, Gomez J, Payne A, Zhang L, Wang X, Dal Pra S, et al. Abi3bp regulates cardiac progenitor cell proliferation and differentiation. Circ Res. 2014;115:1007-16 pubmed publisher
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Duong K, Das S, Yu S, Barr J, Jena S, Kim E, et al. Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells. Exp Hematol. 2014;42:761-72.e1-10 pubmed publisher
Gilmour J, Assi S, Jaegle U, Kulu D, van de Werken H, Clarke D, et al. A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. Development. 2014;141:2391-401 pubmed publisher
Lin Q, Wesson R, Maeda H, Wang Y, Cui Z, Liu J, et al. Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus. J Invest Dermatol. 2014;134:2458-2468 pubmed publisher
Honarpour N, Rose C, Brumbaugh J, Anderson J, Graham R, Sweredoski M, et al. F-box protein FBXL16 binds PP2A-B55? and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics. 2014;13:780-91 pubmed publisher
Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
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Mikami N, Miyagi Y, Sueda K, Takatsuji M, Fukada S, Yamamoto H, et al. Calcitonin gene-related peptide and cyclic adenosine 5'-monophosphate/protein kinase A pathway promote IL-9 production in Th9 differentiation process. J Immunol. 2013;190:4046-55 pubmed publisher
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Koyano Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen T, Borges L, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30:1611-23 pubmed publisher
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Gu P, Min J, Wang Y, Huang C, Peng T, Chai W, et al. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012;31:2309-21 pubmed publisher
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Rodriguez A, Yu J, Guentzel M, Navara C, Klose K, Forsthuber T, et al. Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis. J Immunol. 2012;188:5604-11 pubmed publisher
Zisa D, Shabbir A, Mastri M, Taylor T, Aleksic I, McDaniel M, et al. Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair. Am J Physiol Heart Circ Physiol. 2011;301:H2422-32 pubmed publisher
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Mahlios J, Zhuang Y. Contribution of IL-13 to early exocrinopathy in Id3-/- mice. Mol Immunol. 2011;49:227-33 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD117 (c-Kit) Monoclonal Antibody (2B8), FITC, eBioscience
Catalog # :
11-1171-85
Quantity :
500 ug
Price :
US 354.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse, Porcine
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse, Porcine
Clone :
2B8
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA