This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD95 (APO-1/Fas) Monoclonal Antibody (DX2), FITC, eBioscience™
catalog :
11-0959-41
quantity :
25Tests
price :
US 123
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
DX2
reactivity :
human, dogs
application :
flow cytometry
citations: 9
Reference
Zhang M, Wang J, Jia L, Huang J, He C, Hu F, et al. Transmembrane TNF-? promotes activation-induced cell death by forward and reverse signaling. Oncotarget. 2017;8:63799-63812 pubmed publisher
Kong F, Feng B, Zhang H, Rao H, Wang J, Cong X, et al. Abnormal phenotypic features of IgM+B cell subsets in patients with chronic hepatitis C virus infection. Exp Ther Med. 2017;14:1846-1852 pubmed publisher
Mou H, Moore J, Malonia S, Li Y, Ozata D, Hough S, et al. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2017;114:3648-3653 pubmed publisher
Sun J, Shen Q, Lu H, Jiang Z, Xu W, Feng L, et al. Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance. Oncotarget. 2015;6:41997-2007 pubmed publisher
Lim D, Yawata N, Selva K, Li N, Tsai C, Yeong L, et al. The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. J Immunol. 2014;193:5065-75 pubmed publisher
Shi L, Wang H, Wang F, Feng M, Wang M, Guan W. Effects of gastrokine‑2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways. Mol Med Rep. 2014;10:2898-904 pubmed publisher
Li Q, Wang Y, Wang Y, Zhou Q, Chen K, Wang Y, et al. Distinct different sensitivity of Treg and Th17 cells to Fas-mediated apoptosis signaling in patients with acute coronary syndrome. Int J Clin Exp Pathol. 2013;6:297-307 pubmed
Dompe N, Rivers C, Li L, Cordes S, Schwickart M, Punnoose E, et al. A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2011;108:E943-51 pubmed publisher
Orbach A, Rachmilewitz J, Shani N, Isenberg Y, Parnas M, Huang J, et al. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol. 2010;177:3159-68 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD95 (APO-1/Fas) Monoclonal Antibody (DX2), FITC, eBioscience™
Catalog # :
11-0959-41
Quantity :
25Tests
Price :
US 123
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Canine, Human
Applications :
Flow Cytometry: 5 µL (0.5 µg)/test
Species :
Canine, Human
Clone :
DX2
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.5 µg)/test
Aliases :
ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA