product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD80 (B7-1) Monoclonal Antibody (16-10A1), FITC, eBioscience
catalog :
11-0801-81
quantity :
50 ug
price :
US 107.00
clonality :
monoclonal
host :
hamsters
conjugate :
FITC
clone name :
16-10A1
reactivity :
mouse, dogs, pigs
application :
flow cytometry
more info or order :
citations: 270
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig s10c
Stoff M, Ebbecke T, Ciurkiewicz M, Pavasutthipaisit S, Mayer Lambertz S, St xf6 rk T, et al. C-type lectin receptor DCIR contributes to hippocampal injury in acute neurotropic virus infection. Sci Rep. 2021;11:23819 pubmed publisher
  • flow cytometry; mouse; fig 3
Sun H, Zhang J, Chen F, Chen X, Zhou Z, Wang H. Activation of RAW264.7 macrophages by the polysaccharide from the roots of Actinidia eriantha and its molecular mechanisms. Carbohydr Polym. 2015;121:388-402 pubmed publisher
  • flow cytometry; mouse
Yin Y, Qin T, Wang X, Lin J, Yu Q, Yang Q. CpG DNA assists the whole inactivated H9N2 influenza virus in crossing the intestinal epithelial barriers via transepithelial uptake of dendritic cell dendrites. Mucosal Immunol. 2015;8:799-814 pubmed publisher
  • flow cytometry; mouse; fig 5
Charles E, Joshi S, Ash J, Fox B, Farris A, Bzik D, et al. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010;78:3484-92 pubmed publisher
Chen F, Chen Z, Wu H, Chen X, Zhan P, Wei Z, et al. Mesenchymal Stem Cell-Derived Exosomes Attenuate Murine Cytomegalovirus-Infected Pneumonia via NF-κB/NLRP3 Signaling Pathway. Viruses. 2024;16: pubmed publisher
De Bartolo A, Pasqua T, Romeo N, Rago V, Perrotta I, Giordano F, et al. The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure. J Transl Med. 2024;22:375 pubmed publisher
Xiao J, Xiao H, Cai Y, Liao J, Liu J, Yao L, et al. Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma. Oncol Res. 2024;32:691-702 pubmed publisher
Hu J, Zhang X, Ma F, Huang C, Jiang Y. LncRNA CASC2 Alleviates Renal Interstitial Inflammation and Fibrosis through MEF2C Downregulation-Induced Hinderance of M1 Macrophage Polarization. Nephron. 2024;148:245-263 pubmed publisher
Yao S, Weng D, Wang Y, Zhang Y, Huang Q, Wu K, et al. The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma. J Transl Med. 2023;21:898 pubmed publisher
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Qin A, Wang X, Fu J, Shen A, Huang X, Chen Z, et al. hMSCs treatment attenuates murine herpesvirus-68 (MHV-68) pneumonia through altering innate immune response via ROS/NLRP3 signaling pathway. Mol Biomed. 2023;4:27 pubmed publisher
Luo J, Ren H, Chen M, Zhao Q, Yang N, Liu Q, et al. Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization. iScience. 2023;26:107130 pubmed publisher
Tan H, Cao L. Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway. Immun Inflamm Dis. 2023;11:e830 pubmed publisher
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Xi L, Lin Z, Qiu F, Chen S, Li P, Chen X, et al. Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment. Acta Pharm Sin B. 2022;12:339-352 pubmed publisher
Lv N, Jin S, Liang Z, Wu X, Kang Y, Su L, et al. PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway. Front Immunol. 2021;12:751409 pubmed publisher
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Cousin N, Cap S, Dihr M, Tacconi C, Detmar M, Dieterich L. Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses. Cancer Res. 2021;81:4133-4144 pubmed publisher
Wang J, Chen Q, Zhang Z, Wang S, Wang Y, Xiang M, et al. Azithromycin alleviates systemic lupus erythematosus via the promotion of M2 polarisation in lupus mice. Cell Death Discov. 2021;7:82 pubmed publisher
Kim H, Park J, Park J, Yasmin F, Kim C, Oh S, et al. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. J Hematol Oncol. 2021;14:43 pubmed publisher
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Chen H, Tan J, Li X, Li H, Wu W, Wu Y, et al. Myeloid and plasmacytoid dendritic cell combined vaccines loaded with heat-treated tumor cell lysates enhance antitumor activity in murine lung cancer. Oncol Lett. 2021;21:90 pubmed publisher
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Huang J, Diao G, Zhang Q, Chen Y, Han J, Guo J. E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions. Int J Oncol. 2020;56:921-931 pubmed publisher
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Hrdý J, Alard J, Couturier Maillard A, Boulard O, Boutillier D, Delacre M, et al. Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses. Sci Rep. 2020;10:5345 pubmed publisher
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Chen L, Christian D, Kochanowsky J, Phan A, Clark J, Wang S, et al. The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses. J Exp Med. 2020;217: pubmed publisher
Ciecko A, Foda B, Barr J, Ramanathan S, Atkinson M, Serreze D, et al. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. Cell Rep. 2019;29:3073-3086.e5 pubmed publisher
Thomas A, Dong Y, Beskid N, Garcia A, Adams A, Babensee J. Brief exposure to hyperglycemia activates dendritic cells in vitro and in vivo. J Cell Physiol. 2020;235:5120-5129 pubmed publisher
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Monteiro J, Schön K, Ebbecke T, Goethe R, Ruland J, Baumgartner W, et al. The CARD9-Associated C-Type Lectin, Mincle, Recognizes La Crosse Virus (LACV) but Plays a Limited Role in Early Antiviral Responses against LACV. Viruses. 2019;11: pubmed publisher
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Lin J, Chien C, Lin C, Yao B, Chen Y, Liu Y, et al. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun. 2019;10:1057 pubmed publisher
Quan M, Song X, Liu H, Deng X, Hou H, Chen L, et al. Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses. J Neuroinflammation. 2019;16:52 pubmed publisher
Li Q, Liu C, Yue R, El Ashram S, Wang J, He X, et al. cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection. Int J Mol Sci. 2019;20: pubmed publisher
Moreira D, Adamus T, Zhao X, Su Y, Zhang Z, White S, et al. STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers. Clin Cancer Res. 2018;24:5948-5962 pubmed publisher
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
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Wang Q, He H, Chen D, Wang C, Xu Y, Song W. Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice. Oncotarget. 2017;8:93414-93425 pubmed publisher
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Foubert P, Kaneda M, Varner J. PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression. Cancer Immunol Res. 2017;5:957-968 pubmed publisher
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Hu Z, Chen J, Zhou S, Yang N, Duan S, Zhang Z, et al. Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice. Theranostics. 2017;7:1942-1952 pubmed publisher
Zhou Y, Yoshida S, Kubo Y, Yoshimura T, Kobayashi Y, Nakama T, et al. Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization. Mol Med Rep. 2017;15:3949-3956 pubmed publisher
Li Y, Liu X, Duan W, Tian H, Zhu G, He H, et al. Batf3-dependent CD8?+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. EBioMedicine. 2017;18:188-198 pubmed publisher
Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, et al. Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis. Infect Immun. 2017;85: pubmed publisher
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Wang H, Mo L, Xiao X, An S, Liu X, Ba J, et al. Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model. Sci Rep. 2017;7:43322 pubmed publisher
Ke X, Shen S, Song L, Yu C, Kikuchi M, Hirayama K, et al. Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function. Parasit Vectors. 2017;10:89 pubmed publisher
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
Seleme M, Kosmac K, Jonjic S, Britt W. Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice. J Virol. 2017;91: pubmed publisher
Perobelli S, Mercadante A, Galvani R, Gonçalves Silva T, Alves A, Pereira Neves A, et al. G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way. J Immunol. 2016;197:3725-3734 pubmed
Akhmatova N, Kurbatova E, Akhmatov E, Egorova N, Logunov D, Gening M, et al. The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses. Front Immunol. 2016;7:248 pubmed publisher
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Li J, DU Y, Yan Z, Yan J, Zhuansun Y, Chen R, et al. CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice. Exp Ther Med. 2016;11:878-884 pubmed
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Qin Q, Wang Z, Pan P, Cao Z, Xia Q, Tan H, et al. Lung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor. Exp Ther Med. 2014;8:1402-1408 pubmed
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Yan Y, Ding Y, Ming B, Du W, Kong X, Tian L, et al. Increase in hypotonic stress-induced endocytic activity in macrophages via ClC-3. Mol Cells. 2014;37:418-25 pubmed publisher
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Qian L, Zhang M, Wu S, Zhong Y, Van Tol E, Cai W. Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes. PLoS ONE. 2014;9:e96207 pubmed publisher
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Ramakrishnan R, Tyurin V, Tuyrin V, Veglia F, Condamine T, Amoscato A, et al. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol. 2014;192:2920-31 pubmed publisher
Hu Z, Wang J, Wan Y, Zhu L, Ren X, Qiu S, et al. Boosting functional avidity of CD8+ T cells by vaccinia virus vaccination depends on intrinsic T-cell MyD88 expression but not the inflammatory milieu. J Virol. 2014;88:5356-68 pubmed publisher
Mikami N, Sueda K, Ogitani Y, Otani I, Takatsuji M, Wada Y, et al. Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions. PLoS ONE. 2014;9:e86367 pubmed publisher
Nijhuis L, Olivier B, Dhawan S, Hilbers F, Boon L, Wolkers M, et al. Adrenergic ?2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro. PLoS ONE. 2014;9:e85086 pubmed publisher
Leigh N, Bian G, Ding X, Liu H, Aygun Sunar S, Burdelya L, et al. A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity. PLoS ONE. 2014;9:e85587 pubmed publisher
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Kowalczyk A, D Souza C, Zhang L. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol. 2014;44:1143-55 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Pletinckx K, Lutz M. Dendritic cells generated with Flt3L and exposed to apoptotic cells lack induction of T cell anergy and Foxp3? regulatory T cell conversion in vitro. Immunobiology. 2014;219:230-40 pubmed publisher
Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, et al. Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models. J Innate Immun. 2014;6:293-305 pubmed publisher
Maina V, Marrella V, Mantero S, Cassani B, Fontana E, Anselmo A, et al. Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol. 2013;94:1221-30 pubmed publisher
Katakai T, Habiro K, Kinashi T. Dendritic cells regulate high-speed interstitial T cell migration in the lymph node via LFA-1/ICAM-1. J Immunol. 2013;191:1188-99 pubmed publisher
Garcia J, Pino P, Mizutani M, Cardona S, Charo I, Ransohoff R, et al. Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation. J Immunol. 2013;191:1063-72 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD80 (B7-1) Monoclonal Antibody (16-10A1), FITC, eBioscience
Catalog # :
11-0801-81
Quantity :
50 ug
Price :
US 107.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Canine, Mouse, Porcine
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Canine, Mouse, Porcine
Clone :
16-10A1
Isotype :
IgG
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
Activation B7-1 antigen; B7; B7 protein; B7.1; B71; B7-1; B7-1 protein; B7-1 protein precursor; BB1; B-lymphocyte activation antigen B7; Cd28l; CD28LG; CD28LG1; CD80; Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1); CD80 anitgen; CD80 antigen; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Cd80 molecule; CD80 protein precursor; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; Ly53; Ly-53; MIC17; sCD 80; sCD80; secreted B7-1 protein precursor; soluble CD 80; soluble CD80; T-cell costimulatory molecule; T-cell co-stimulatory protein B7-1; T-lymphocyte activation antigen CD80; TS/A-1; TSA1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA