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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD45RO Monoclonal Antibody (UCHL1), FITC, eBioscience
catalog :
11-0457-42
quantity :
100 Tests
price :
US 217.00
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
UCHL1
reactivity :
human
application :
flow cytometry
more info or order :
citations: 63
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Qi Y, Operario D, Georas S, Mosmann T. The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PLoS ONE. 2012;7:e39072 pubmed publisher
Ye X, Shih D, Ku Z, Hong J, Barrett D, Rupp R, et al. Transcriptional signature of durable effector T cells elicited by a replication defective HCMV vaccine. NPJ Vaccines. 2024;9:70 pubmed publisher
Kendirli A, de la Rosa C, L xe4 mmle K, Eglseer K, Bauer I, Kavaka V, et al. A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model. Nat Neurosci. 2023;26:1713-1725 pubmed publisher
Zhang Y, Luo F, Dong K. Soluble NKG2D ligands impair CD8+ T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncol Lett. 2023;26:297 pubmed publisher
Gigliotti C, Boggio E, Favero F, Incarnato D, Santoro C, Oliviero S, et al. Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4+ T cells. Front Immunol. 2022;13:915963 pubmed publisher
Dhariwala M, Karthikeyan D, Vasquez K, Farhat S, Weckel A, Taravati K, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020;1:100132 pubmed publisher
Gartner M, Gorry P, Tumpach C, Zhou J, Dantanarayana A, Chang J, et al. Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection. Retrovirology. 2020;17:24 pubmed publisher
de Macedo Abdo L, Barros L, Saldanha Viegas M, Vieira Codeço Marques L, de Sousa Ferreira P, Chicaybam L, et al. Development of CAR-T cell therapy for B-ALL using a point-of-care approach. Oncoimmunology. 2020;9:1752592 pubmed publisher
Lowe M, Boothby I, Clancy S, Ahn R, Liao W, Nguyen D, et al. Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019;4: pubmed publisher
Novak P, Schmidt R, Kontsekova E, Kovacech B, Smolek T, Katina S, et al. FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease. Alzheimers Res Ther. 2018;10:108 pubmed publisher
Bock C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn M, et al. Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells. Front Cell Infect Microbiol. 2017;7:261 pubmed publisher
Li X, Dai D, Song X, Liu J, Zhu L, Zhu X, et al. A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma. Oncol Lett. 2017;13:3291-3298 pubmed publisher
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed publisher
Sheng S, Gu Y, Lu C, Tang Y, Zou J, Zhang Y, et al. The Characteristics of Naive-like T Cells in Tumor-infiltrating Lymphocytes From Human Lung Cancer. J Immunother. 2017;40:1-10 pubmed
Alfaro C, Echeveste J, Rodriguez Ruiz M, Solorzano J, Perez Gracia J, Idoate M, et al. Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology. 2015;4:e1054597 pubmed
Broos C, van Nimwegen M, Kleinjan A, Ten Berge B, Muskens F, In t Veen J, et al. Impaired survival of regulatory T cells in pulmonary sarcoidosis. Respir Res. 2015;16:108 pubmed publisher
Catelas I, Lehoux E, Hurda I, Baskey S, Gala L, Foster R, et al. Do patients with a failed metal-on-metal hip implant with a pseudotumor present differences in their peripheral blood lymphocyte subpopulations?. Clin Orthop Relat Res. 2015;473:3903-14 pubmed publisher
Wyluda E, Cheng J, Schell T, Haley J, Mallon C, Neves R, et al. Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy. Cancer Biol Ther. 2015;16:662-70 pubmed publisher
Katawa G, Layland L, Debrah A, von Horn C, Batsa L, Kwarteng A, et al. Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells. PLoS Negl Trop Dis. 2015;9:e3414 pubmed publisher
Liu M, Wang C. Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus erythematosus. Lupus Sci Med. 2014;1:e000062 pubmed publisher
Ivanova I, Seledtsova G, Mamaev S, Shishkov A, Seledtsov V. Immune responses induced by T-cell vaccination in patients with rheumatoid arthritis. Hum Vaccin Immunother. 2014;10:1221-7 pubmed publisher
Sutavani R, Bradley R, Ramage J, Jackson A, Durrant L, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol. 2013;191:5895-903 pubmed publisher
Valentine M, Song K, Maresh G, Mack H, Huaman M, Polacino P, et al. Expression of the memory marker CD45RO on helper T cells in macaques. PLoS ONE. 2013;8:e73969 pubmed publisher
Fang L, Lowther D, Meizlish M, Anderson R, Bruce J, Devine L, et al. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro Oncol. 2013;15:1479-90 pubmed publisher
Kumar S, Naqvi R, Ali R, Rani R, Khanna N, Rao D. CD4+CD25+ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy. Mol Immunol. 2013;56:513-20 pubmed publisher
Jenks J, Seki S, Kanai T, Huang J, Morgan A, Scalco R, et al. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013;148:227-36 pubmed publisher
Gooden M, Wiersma V, Samplonius D, Gerssen J, van Ginkel R, Nijman H, et al. Galectin-9 activates and expands human T-helper 1 cells. PLoS ONE. 2013;8:e65616 pubmed publisher
Kamburova E, Koenen H, Borgman K, ten Berge I, Joosten I, Hilbrands L. A single dose of rituximab does not deplete B cells in secondary lymphoid organs but alters phenotype and function. Am J Transplant. 2013;13:1503-11 pubmed publisher
Feuth T, Arends J, Fransen J, Nanlohy N, van Erpecum K, Siersema P, et al. Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection. PLoS ONE. 2013;8:e59302 pubmed publisher
Nikiforow S, Kim H, Bindra B, McDonough S, Glotzbecker B, Armand P, et al. Phase I study of alemtuzumab for therapy of steroid-refractory chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2013;19:804-11 pubmed publisher
Chang S, Thomas M, Sova P, Green R, Palermo R, Katze M. Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microrna expression patterns and candidate novel microRNAs differentially expressed upon infection. MBio. 2013;4:e00549-12 pubmed publisher
Na I, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, et al. Rabbit antithymocyte globulin (thymoglobulin) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica. 2013;98:23-30 pubmed publisher
Sage P, Varghese L, Martinelli R, Sciuto T, Kamei M, Dvorak A, et al. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol. 2012;188:3686-99 pubmed publisher
Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed publisher
Fogal B, Yi T, Wang C, Rao D, Lebastchi A, Kulkarni S, et al. Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells. J Immunol. 2011;187:6268-80 pubmed publisher
Simhadri V, Mariano J, Zhou Q, DeBell K, Borrego F. Differential expression of CD300a/c on human TH1 and TH17 cells. BMC Immunol. 2011;12:62 pubmed publisher
Hildebrandt M, Dijkstra D, Gollasch H, Daemen K, Stevanovic Meyer M, Ludwig W. Apheresis-related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation. Transfusion. 2012;52:765-76 pubmed publisher
Aly L, Yousef S, Schippling S, Jelcic I, Breiden P, Matschke J, et al. Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome. Brain. 2011;134:2687-702 pubmed publisher
Landrigan A, Wong M, Utz P. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-43 pubmed publisher
Bentebibel S, Schmitt N, Banchereau J, Ueno H. Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. Proc Natl Acad Sci U S A. 2011;108:E488-97 pubmed publisher
Ciccone E, Greenwald J, Lee P, Biancotto A, Read S, Yao M, et al. CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors. J Virol. 2011;85:5880-8 pubmed publisher
Mackroth M, Malhotra I, Mungai P, Koech D, Muchiri E, King C. Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens. J Immunol. 2011;186:2780-91 pubmed publisher
Llanos Cuentas A, Calderon W, Cruz M, Ashman J, Alves F, Coler R, et al. A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis. Vaccine. 2010;28:7427-35 pubmed publisher
Kaur G, Goodall J, Jarvis L, Hill Gaston J. Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells--identification of Foxp3?7 in human regulatory T cells. Mol Immunol. 2010;48:321-32 pubmed publisher
Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri V, DeBell K, et al. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE. 2010;5:e10636 pubmed publisher
Beriou G, Bradshaw E, Lozano E, Costantino C, Hastings W, Orban T, et al. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010;185:46-54 pubmed publisher
Brucklacher Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J Immunol. 2009;183:5494-501 pubmed publisher
Huarte E, Fisher J, Turk M, Mellinger D, Foster C, Wolf B, et al. Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma. Cancer Lett. 2009;285:80-8 pubmed publisher
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
Cummings K, Rosen H, Hahn Y. Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol. 2009;132:401-11 pubmed publisher
Sereti I, Dunham R, Spritzler J, Aga E, Proschan M, Medvik K, et al. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood. 2009;113:6304-14 pubmed publisher
Gang C, Jiahui Y, Huaizhou W, Qing C, Dongbao Z, Qian S. Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4(+) and CD8(+) T-cell dysfunction in patients with active SLE. Cell Immunol. 2009;258:83-9 pubmed publisher
Horlock C, Stott B, Dyson P, Morishita M, Coombes R, Savage P, et al. The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer. Br J Cancer. 2009;100:1061-7 pubmed publisher
Thakkar N, Pirrone V, Passic S, Zhu W, Kholodovych V, Welsh W, et al. Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection. Antimicrob Agents Chemother. 2009;53:631-8 pubmed publisher
Azevedo R, Soares M, Barata J, Tendeiro R, Serra Caetano A, Victorino R, et al. IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner. Blood. 2009;113:2999-3007 pubmed publisher
Figueroa Tentori D, Querol S, Dodi I, Madrigal A, Duggleby R. High purity and yield of natural Tregs from cord blood using a single step selection method. J Immunol Methods. 2008;339:228-35 pubmed publisher
Chiba H, Ishii G, Ito T, Aoyagi K, Sasaki H, Nagai K, et al. CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. Stem Cells. 2008;26:2523-30 pubmed publisher
Butte M, Pena Cruz V, Kim M, Freeman G, Sharpe A. Interaction of human PD-L1 and B7-1. Mol Immunol. 2008;45:3567-72 pubmed publisher
Thakral D, Dobbins J, Devine L, Kavathas P. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 2008;180:7431-42 pubmed
van Mierlo G, Scherer H, Hameetman M, Morgan M, Flierman R, Huizinga T, et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol. 2008;180:2747-51 pubmed
Saada J, Pinchuk I, Barrera C, Adegboyega P, Suarez G, Mifflin R, et al. Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa. J Immunol. 2006;177:5968-79 pubmed
Bossaller L, Burger J, Draeger R, Grimbacher B, Knoth R, Plebani A, et al. ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol. 2006;177:4927-32 pubmed
product information
Product Type :
Antibody
Product Name :
CD45RO Monoclonal Antibody (UCHL1), FITC, eBioscience
Catalog # :
11-0457-42
Quantity :
100 Tests
Price :
US 217.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.5 ug)/test
Species :
Human
Clone :
UCHL1
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.5 ug)/test
Aliases :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA