CD33 Monoclonal Antibody (WM-53 (WM53)), FITC, eBioscience | Invitrogen 11-0338-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD33 Monoclonal Antibody (WM-53 (WM53)), FITC, eBioscience

catalog :

11-0338-42

quantity :

100 Tests

price :

US 252.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

WM-53 (WM53)

reactivity :

human

application :

flow cytometry

citations: 22

Reference
Wan Y, Mu X, Zhao J, Li L, Xu W, Zhang M. Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomed Rep. 2024;20:68 pubmed publisher
Zhou J, Wang H, Shu T, Wang J, Yang W, Li J, et al. Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. iScience. 2023;26:107626 pubmed publisher
Jianyi D, Haili G, Bo Y, Meiqin Y, Baoyou H, Haoran H, et al. Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer. Cancer Immunol Immunother. 2023;72:73-85 pubmed publisher
Schmitz C, Alt C, Azares A, Pearce D, Facile T, Furia J, et al. The Composition of Adipose-Derived Regenerative Cells Isolated from Lipoaspirate Using a Point of Care System Does Not Depend on the Subject's Individual Age, Sex, Body Mass Index and Ethnicity. Cells. 2022;12: pubmed publisher
Hudec M, Riegerov xe1 K, Pala J, K xfa tna V, x10c ern xe1 M, O Leary V. Celiac Disease Defined by Over-Sensitivity to Gliadin Activation and Superior Antigen Presentation of Dendritic Cells. Int J Mol Sci. 2021;22: pubmed publisher
Ombrato L, Nolan E, Passaro D, Kurelac I, Bridgeman V, Waclawiczek A, et al. Generation of neighbor-labeling cells to study intercellular interactions in vivo. Nat Protoc. 2021;16:872-892 pubmed publisher
Ni H, Zhang L, Huang H, Dai S, Li J. Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer. J Transl Med. 2020;18:393 pubmed publisher
Zhang C, Huang D, Baloche V, Zhang L, Xu J, Li B, et al. Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation. Oncogenesis. 2020;9:65 pubmed publisher
Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, et al. iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity. Stem Cell Reports. 2020;14:49-59 pubmed publisher
Pathangey L, McCurry D, Gendler S, Dominguez A, Gorman J, Pathangey G, et al. Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens. Oncotarget. 2017;8:10785-10808 pubmed publisher
KyttÃ¤lÃ¤ A, Moraghebi R, Valensisi C, Kettunen J, Andrus C, Pasumarthy K, et al. Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential. Stem Cell Reports. 2016;6:200-12 pubmed publisher
Breton G, Lee J, Liu K, Nussenzweig M. Defining human dendritic cell progenitors by multiparametric flow cytometry. Nat Protoc. 2015;10:1407-22 pubmed publisher
Pallett L, Gill U, Quaglia A, Sinclair L, Jover Cobos M, Schurich A, et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat Med. 2015;21:591-600 pubmed publisher
Koba C, Haruta M, Matsunaga Y, Matsumura K, Haga E, Sasaki Y, et al. Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-? against peritoneally disseminated cancer in xenograft models. PLoS ONE. 2013;8:e67567 pubmed publisher
Cloke T, Munder M, Taylor G, Muller I, Kropf P. Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection. PLoS ONE. 2012;7:e48939 pubmed publisher
Radomska H, Alberich Jorda M, Will B, Gonzalez D, Delwel R, Tenen D. Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBP?. J Clin Invest. 2012;122:2955-66 pubmed publisher
Braunstein I, Goodman N, Rosenbach M, Okawa J, Shah A, Krathen M, et al. Lenalidomide therapy in treatment-refractory cutaneous lupus erythematosus: histologic and circulating leukocyte profile and potential risk of a systemic lupus flare. J Am Acad Dermatol. 2012;66:571-82 pubmed publisher
Zhang H, Zhao C, Li X, Zhu Y, Gan C, Wang Y, et al. Study of monocyte membrane proteome perturbation during lipopolysaccharide-induced tolerance using iTRAQ-based quantitative proteomic approach. Proteomics. 2010;10:2780-9 pubmed publisher
Shamsasenjan K, Otsuyama K, Abroun S, Iqbal M, Mahmoud M, Asaoku H, et al. IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells. Int J Hematol. 2009;89:310-318 pubmed publisher
Schenk M, Bouchon A, Seibold F, Mueller C. TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest. 2007;117:3097-106 pubmed
McCully M, Chau T, Luke P, Blake P, Madrenas J. Characterization of human peritoneal dendritic cell precursors and their involvement in peritonitis. Clin Exp Immunol. 2005;139:513-25 pubmed
Schenk M, Bouchon A, Birrer S, Colonna M, Mueller C. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol. 2005;174:517-24 pubmed

product information

Product Type :

Antibody

Product Name :

CD33 Monoclonal Antibody (WM-53 (WM53)), FITC, eBioscience

Catalog # :

11-0338-42

Quantity :

100 Tests

Price :

US 252.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Human

Clone :

WM-53 (WM53)

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3