This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD18 (LFA-1 beta) Monoclonal Antibody (M18/2), FITC, eBioscience
catalog :
11-0181-82
quantity :
100 ug
price :
US 198.00
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
M18/2

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 15
Reference
Huang F, Du Y, Chen Y, Qiu Z, Wang Z, Fan Y, et al. Cellular Membrane-Engineered Nanovesicles as a Three-Stage Booster to Target the Lesion Core. Adv Mater. 2023;35:e2302801 pubmed publisher
Veazey J, Wong G, Eliseeva S, Smyth T, Chapman T, Lim K, et al. Protein kinase D3 promotes neutrophil migration during viral infection. Immunol Cell Biol. 2023;101:130-141 pubmed publisher
Ivan D, Walthert S, Locatelli G. Central Nervous System Barriers Impact Distribution and Expression of iNOS and Arginase-1 in Infiltrating Macrophages During Neuroinflammation. Front Immunol. 2021;12:666961 pubmed publisher
Ives A, Le Roy D, Th xe9 roude C, Bernhagen J, Roger T, Calandra T. Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway. FASEB J. 2021;35:e21418 pubmed publisher
Kim H, Park J, Park J, Yasmin F, Kim C, Oh S, et al. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. J Hematol Oncol. 2021;14:43 pubmed publisher
Li W, Chen S, Luo Y, Xia Y, Ma Q, Yao Q, et al. Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease. Exp Ther Med. 2020;20:1021-1029 pubmed publisher
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro Oonuma T, Hwang Y, et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. 2017;2:e90905 pubmed publisher
Hersrud S, Kovács A, Pearce D. Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis. Biochim Biophys Acta. 2016;1862:1324-36 pubmed publisher
Gawden Bone C, West M, Morrison V, Edgar A, McMillan S, Dill B, et al. A crucial role for ?2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells. J Cell Sci. 2014;127:4213-24 pubmed publisher
Costola de Souza C, Ribeiro A, Ferraz de Paula V, Calefi A, Aloia T, Gimenes Júnior J, et al. Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. PLoS ONE. 2013;8:e77706 pubmed publisher
Hellvard A, Maresz K, Schilling S, Graubner S, Heiser U, Jonsson R, et al. Glutaminyl cyclases as novel targets for the treatment of septic arthritis. J Infect Dis. 2013;207:768-77 pubmed publisher
Fock R, Vinolo M, Blatt S, Borelli P. Impairment of the hematological response and interleukin-1β production in protein-energy malnourished mice after endotoxemia with lipopolysaccharide. Braz J Med Biol Res. 2012;45:1163-71 pubmed
Fogelstrand P, Feral C, Zargham R, Ginsberg M. Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2). J Exp Med. 2009;206:2397-406 pubmed publisher
Nobumoto A, Nagahara K, Oomizu S, Katoh S, Nishi N, Takeshita K, et al. Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices. Glycobiology. 2008;18:735-44 pubmed publisher
Godek M, Michel R, Chamberlain L, Castner D, Grainger D. Adsorbed serum albumin is permissive to macrophage attachment to perfluorocarbon polymer surfaces in culture. J Biomed Mater Res A. 2009;88:503-19 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD18 (LFA-1 beta) Monoclonal Antibody (M18/2), FITC, eBioscience
Catalog # :
11-0181-82
Quantity :
100 ug
Price :
US 198.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test
Species :
Mouse
Clone :
M18/2
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test
Aliases :
2E6; AI528527; antigen CD18; B-2 integrin; CD18; CD18 leukocyte adhesion molecule; CD18 subunit; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta 2; integrin beta chain, beta 2; integrin beta-2; integrin subunit beta 2; integrin, beta 2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit); integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITGB2; LAD; LCAMB; Leu-CAM receptor; leukocyte cell adhesion molecule CD18; leukocyte surface protein; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; Lfa1; LFA-1; lymphocyte function associated antigen 1; MAC-1; Mac-1 beta; macrophage antigen 1 (mac-1) beta subunit); macrophage antigen-1 beta; MF17; MFI7
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA