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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD11a (LFA-1alpha) Monoclonal Antibody (M17/4), FITC, eBioscience™
catalog :
11-0111-85
quantity :
500 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
M17/4
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 19
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 2
Cabrera Perez J, Condotta S, James B, Kashem S, Brincks E, Rai D, et al. Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol. 2015;194:1609-20 pubmed publisher
  • flow cytometry; mouse; fig 5d
Shindo Y, Unsinger J, Burnham C, Green J, Hotchkiss R. Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock. 2015;43:334-43 pubmed publisher
Van Braeckel Budimir N, Varga S, Badovinac V, Harty J. Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Rep. 2018;24:3374-3382.e3 pubmed publisher
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed publisher
Cauvi D, Cauvi G, Toomey C, Jacquinet E, POLLARD K. From the Cover: Interplay Between IFN-? and IL-6 Impacts the Inflammatory Response and Expression of Interferon-Regulated Genes in Environmental-Induced Autoimmunity. Toxicol Sci. 2017;158:227-239 pubmed publisher
Hobbs C, Anderson C, Neal J, Sahu T, Conteh S, Voza T, et al. Trimethoprim-Sulfamethoxazole Prophylaxis During Live Malaria Sporozoite Immunization Induces Long-Lived, Homologous, and Heterologous Protective Immunity Against Sporozoite Challenge. J Infect Dis. 2017;215:122-130 pubmed publisher
Lewis G, Wehrens E, Labarta Bajo L, Streeck H, Zuniga E. TGF-? receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016;126:3799-3813 pubmed publisher
Braach N, Buschmann K, Pflaum J, Hudalla H, Koch L, Ryschich E, et al. Anti-inflammatory functions of protein C require RAGE and ICAM-1 in a stimulus-dependent manner. Mediators Inflamm. 2014;2014:743678 pubmed publisher
Chang K, Burnham C, Compton S, Rasche D, Mazuski R, McDonough J, et al. Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care. 2013;17:R85 pubmed publisher
Xu N, Hossain M, Liu L. Pharmacological inhibition of p38 mitogen-activated protein kinases affects KC/CXCL1-induced intraluminal crawling, transendothelial migration, and chemotaxis of neutrophils in vivo. Mediators Inflamm. 2013;2013:290565 pubmed publisher
Ryu S, Kang B, Kim S, Kim T, Chang J, Choi E. Requirement of CD4 help for induction of CD8 T cell response specific for virally derived h60. Immune Netw. 2012;12:118-25 pubmed publisher
Ryu S, Jeon J, Chang J, Sproule T, Roopenian D, Choi E. A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment. Mol Cells. 2012;33:393-9 pubmed publisher
Jeon J, Jung K, Chang J, Choi E. Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen. Immune Netw. 2011;11:100-6 pubmed publisher
Uchida Y, Kawai K, Ibusuki A, Kanekura T. Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cells. J Immunol. 2011;186:6945-54 pubmed publisher
DeNucci C, Shimizu Y. ?1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory. J Immunol. 2011;186:4019-26 pubmed publisher
Schmidt N, Harty J. Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization. J Immunol. 2011;186:3836-40 pubmed publisher
Welch J, Klco J, Varghese N, Nagarajan R, Ley T. Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. Blood. 2011;117:2460-8 pubmed publisher
Zhao X, Zhang M, Li Z, Frankel F. Vaginal protection and immunity after oral immunization of mice with a novel vaccine strain of Listeria monocytogenes expressing human immunodeficiency virus type 1 gag. J Virol. 2006;80:8880-90 pubmed
Zhao X, Li Z, Gu B, Frankel F. Pathogenicity and immunogenicity of a vaccine strain of Listeria monocytogenes that relies on a suicide plasmid to supply an essential gene product. Infect Immun. 2005;73:5789-98 pubmed
product information
Product Type :
Antibody
Product Name :
CD11a (LFA-1alpha) Monoclonal Antibody (M17/4), FITC, eBioscience™
Catalog # :
11-0111-85
Quantity :
500 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
M17/4
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. CD11a is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of CD11a to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. CD11a is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of CD11a function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti- CD11a antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. Two transcript variants encoding different isoforms of CD11a have been found. Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
(p180); alpha L integrin; antigen CD11A (p180); antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; antigen CD11A p180; CD11 antigen-like family member A; CD11a; integrin alpha L; integrin alphaL; integrin alpha-L; integrin alpha-L precursor; integrin gene promoter; integrin subunit alpha L; integrin surface receptor; integrin, alpha L; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide; lymphocyte function-associated antigen 1; lymphocyte function-associated antigen 1, alpha polypeptide; lymphocyte function-associated antigen-1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA