This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD8a Monoclonal Antibody (OKT8 (OKT-8)), FITC, eBioscience
catalog :
11-0086-41
quantity :
25 Tests
price :
US 97.00
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
OKT8 (OKT-8)
reactivity :
human
application :
flow cytometry
citations: 63
Reference
Federico L, Tvedt T, Gainullin M, Osen J, Chaban V, Lund K, et al. Robust spike-specific CD4+ and CD8+ T cell responses in SARS-CoV-2 vaccinated hematopoietic cell transplantation recipients: a prospective, cohort study. Front Immunol. 2023;14:1210899 pubmed publisher
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Hu Y, Chen Y, Chen Z, Zhang X, Guo C, Yu Z, et al. Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients. Front Cell Dev Biol. 2021;9:799560 pubmed publisher
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Zhang S, Jiang V, Han G, Hao D, Lian J, Liu Y, et al. Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma. Nat Commun. 2021;12:2877 pubmed publisher
Rovito D, Rerra A, Ueberschlag Pitiot V, Joshi S, Karasu N, Dacleu Siewe V, et al. Myod1 and GR coordinate myofiber-specific transcriptional enhancers. Nucleic Acids Res. 2021;49:4472-4492 pubmed publisher
Zhou J, Wang W, Liang Z, Ni B, He W, Wang D. Clinical significance of CD38 and CD101 expression in PD-1+CD8+ T cells in patients with epithelial ovarian cancer. Oncol Lett. 2020;20:724-732 pubmed publisher
Yang X, Zeng Q, Göktaş E, Gopal K, Al Aswad L, Blumberg D, et al. T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma. Invest Ophthalmol Vis Sci. 2019;60:877-888 pubmed publisher
Zhang M, Yang J, Zhou J, Gao W, Zhang Y, Lin Y, et al. Prognostic Values of CD38+CD101+PD1+CD8+ T Cells in Pancreatic Cancer. Immunol Invest. 2019;48:466-479 pubmed publisher
Guo X, Jiang H, Shi B, Zhou M, Zhang H, Shi Z, et al. Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma. Front Pharmacol. 2018;9:1118 pubmed publisher
Narasimhan P, Akabas L, Tariq S, Huda N, Bennuru S, Sabzevari H, et al. Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion. PLoS Negl Trop Dis. 2018;12:e0006404 pubmed publisher
Reber A, Music N, Kim J, Gansebom S, Chen J, York I. Extensive T cell cross-reactivity between diverse seasonal influenza strains in the ferret model. Sci Rep. 2018;8:6112 pubmed publisher
Fuery A, Leen A, Peng R, Wong M, Liu H, Ling P. Asian Elephant T Cell Responses to Elephant Endotheliotropic Herpesvirus. J Virol. 2018;92: pubmed publisher
Horn L, Ciavattone N, Atkinson R, Woldergerima N, Wolf J, Clements V, et al. CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1+ tumor cells, and extends the survival of tumor-bearing humanized mice. Oncotarget. 2017;8:57964-57980 pubmed publisher
Wang W, Cheng Z, Chen Y, Lin Y. Increased circulating IL-9-producing CD8+ T cells are associated with eosinophilia and high FeNO in allergic asthmatics. Exp Ther Med. 2016;12:4055-4060 pubmed publisher
Dendrou C, Cortes A, Shipman L, Evans H, Attfield K, Jostins L, et al. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med. 2016;8:363ra149 pubmed
Liu Z, Han H, He X, Li S, Wu C, Yu C, et al. Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncol Lett. 2016;11:1829-1834 pubmed
Hassan S, Akram M, King E, Dockrell H, Cliff J. PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment. PLoS ONE. 2015;10:e0137646 pubmed publisher
Nduom E, Wei J, Yaghi N, Huang N, Kong L, Gabrusiewicz K, et al. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol. 2016;18:195-205 pubmed publisher
Clairfeuille T, Norwood S, Qi X, Teasdale R, Collins B. Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21. J Biol Chem. 2015;290:14504-17 pubmed publisher
Reichwald K, Jørgensen T, Skov S. TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells. PLoS ONE. 2014;9:e105627 pubmed publisher
Larsen J, Brix S, Thysen A, Birch S, Rasmussen M, Bisgaard H. Children with asthma by school age display aberrant immune responses to pathogenic airway bacteria as infants. J Allergy Clin Immunol. 2014;133:1008-13 pubmed publisher
Lipp A, Juhász K, Paar C, Ogris C, Eckerstorfer P, Thuenauer R, et al. Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells. PLoS ONE. 2014;9:e85934 pubmed publisher
Hassan S, Cho J, Akram M, Fielding K, Dockrell H, Cliff J. Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cure. PLoS ONE. 2013;8:e70063 pubmed publisher
Zhang W, Nie L, Wang Y, Wang X, Zhao H, Dongol S, et al. CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues. PLoS ONE. 2013;8:e66286 pubmed publisher
Diedrich C, Mattila J, Flynn J. Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection. J Immunol. 2013;190:6320-8 pubmed publisher
Dössinger G, Bunse M, Bet J, Albrecht J, Paszkiewicz P, Weißbrich B, et al. MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy. PLoS ONE. 2013;8:e61384 pubmed publisher
Thakral D, Coman M, Bandyopadhyay A, Martin S, Riley J, Kavathas P. The human CD8? M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties. PLoS ONE. 2013;8:e59374 pubmed publisher
Azevedo R, Soares M, Albuquerque A, Tendeiro R, Soares R, Martins M, et al. Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:703-12 pubmed publisher
Freeman C, Martinez F, Han M, Washko G, McCubbrey A, Chensue S, et al. Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respir Res. 2013;14:13 pubmed publisher
Marin N, Paris S, Rojas M, Garcia L. Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB. Tuberculosis (Edinb). 2013;93:155-66 pubmed publisher
Schroeder J, Simbi B, Ford L, Cole S, Taylor M, Lawson C, et al. Live Brugia malayi microfilariae inhibit transendothelial migration of neutrophils and monocytes. PLoS Negl Trop Dis. 2012;6:e1914 pubmed publisher
Chueh F, Yu C. Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells. Biochem Biophys Res Commun. 2012;426:242-6 pubmed publisher
Marin N, Paris S, Rojas M, Garcia L. Reduced frequency of memory T cells and increased Th17 responses in patients with active tuberculosis. Clin Vaccine Immunol. 2012;19:1667-76 pubmed
Kiyasu J, Aoki R, Tanaka P, Pracchia L, Calore E, Perez N, et al. FOXP3(+) regulatory and TIA-1(+) cytotoxic T lymphocytes in HIV-associated Hodgkin lymphoma. Pathol Int. 2012;62:77-83 pubmed publisher
Biswas S, Chang H, Sarkis P, Fikrig E, Zhu Q, Marasco W. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011;134:419-33 pubmed publisher
Clement M, Ladell K, Ekeruche Makinde J, Miles J, Edwards E, Dolton G, et al. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. J Immunol. 2011;187:654-63 pubmed publisher
Coffelt S, Chen Y, Muthana M, Welford A, Tal A, Scholz A, et al. Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. J Immunol. 2011;186:4183-90 pubmed publisher
Zhou X, McElhaney J. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine. 2011;29:2169-77 pubmed publisher
Mattila J, Diedrich C, Lin P, Phuah J, Flynn J. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011;186:3527-37 pubmed publisher
Araya N, Takahashi K, Sato T, Nakamura T, Sawa C, Hasegawa D, et al. Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease. Antivir Ther. 2011;16:89-98 pubmed publisher
Zloza A, Jagoda M, Lyons G, Graves M, Kohlhapp F, O Sullivan J, et al. CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-? (TGF-?)-mediated suppression. Cancer Immunol Immunother. 2011;60:291-7 pubmed publisher
Ellebedy A, Fabrizio T, Kayali G, Oguin T, Brown S, Rehg J, et al. Contemporary seasonal influenza A (H1N1) virus infection primes for a more robust response to split inactivated pandemic influenza A (H1N1) Virus vaccination in ferrets. Clin Vaccine Immunol. 2010;17:1998-2006 pubmed publisher
Comin Anduix B, Sazegar H, Chodon T, Matsunaga D, Jalil J, von Euw E, et al. Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma. PLoS ONE. 2010;5:e12711 pubmed publisher
Lai A, Fatemi M, Dhasarathy A, Malone C, Sobol S, Geigerman C, et al. DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med. 2010;207:1939-50 pubmed publisher
Rottembourg D, Deal C, Lambert M, Mallone R, Carel J, Lacroix A, et al. 21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease. J Autoimmun. 2010;35:309-15 pubmed publisher
Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med. 2010;16:713-7 pubmed publisher
Diedrich C, Mattila J, Klein E, Janssen C, Phuah J, Sturgeon T, et al. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. PLoS ONE. 2010;5:e9611 pubmed publisher
Luo N, Wu Y, Chen Y, Yang Z, Guo S, Fei L, et al. Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus. Clin Immunol. 2009;132:349-61 pubmed publisher
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
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Chaitra M, Shaila M, Nayak R. Detection of interferon gamma-secreting CD8+ T lymphocytes in humans specific for three PE/PPE proteins of Mycobacterium tuberculosis. Microbes Infect. 2008;10:858-67 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD8a Monoclonal Antibody (OKT8 (OKT-8)), FITC, eBioscience
Catalog # :
11-0086-41
Quantity :
25 Tests
Price :
US 97.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.06 ug)/test
Species :
Human
Clone :
OKT8 (OKT-8)
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.06 ug)/test
Aliases :
BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA