CD8a Monoclonal Antibody (OX8), FITC, eBioscience™ | Invitrogen 11-0084-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD8a Monoclonal Antibody (OX8), FITC, eBioscience™

catalog :

11-0084-80

quantity :

25µg

price :

US 64.5

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

OX8

reactivity :

rat

application :

flow cytometry

citations: 5

Reference
Liu Y, Sun L, Chen W, Chuai J, Shang Y, Zhang D, et al. Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells. Exp Ther Med. 2018;15:1941-1949 pubmed publisher
Zheng W, Zhang B, Shen Z, Yin M, Cao Y, Song H. Biological effects of bone marrow mesenchymal stem cells on hepatitis B virus inÂ vitro. Mol Med Rep. 2017;15:2551-2559 pubmed publisher
Berinstein N, Karkada M, Oza A, Odunsi K, Villella J, Nemunaitis J, et al. Survivin-targeted immunotherapy drives robust polyfunctional T cell generation and differentiation in advanced ovarian cancer patients. Oncoimmunology. 2015;4:e1026529 pubmed
May E, Dorris M, Satumtira N, Iqbal I, Rehman M, Lightfoot E, et al. CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol. 2003;170:1099-105 pubmed
Johnson P, Gagnon J, Barclay A, Williams A. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. EMBO J. 1985;4:2539-45 pubmed

product information

Product Type :

Antibody

Product Name :

CD8a Monoclonal Antibody (OX8), FITC, eBioscience™

Catalog # :

11-0084-80

Quantity :

25µg

Price :

US 64.5

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Rat

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Rat

Clone :

OX8

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

CD8, Leu-2, MAL, p32, CD8a