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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD81 Monoclonal Antibody (M38)
catalog :
10630D
quantity :
200 uL
price :
US 336.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
M38
reactivity :
human, mouse
application :
western blot
more info or order :
citations: 64
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 5c
Liu C, Chen Q, Shang Y, Chen L, Myers J, Awadallah A, et al. Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche. Theranostics. 2022;12:2894-2907 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 6b
Tabariès S, Annis M, Lazaris A, Petrillo S, Huxham J, Abdellatif A, et al. Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern. Commun Biol. 2021;4:657 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s1d
Jang S, Economides K, Moniz R, Sia C, Lewis N, McCoy C, et al. ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance. Commun Biol. 2021;4:497 pubmed publisher
  • western blot; human; fig 3
Guo H, Petrin D, Zhang Y, Bergeron C, Goodyer C, LeBlanc A. Caspase-1 activation of caspase-6 in human apoptotic neurons. Cell Death Differ. 2006;13:285-92 pubmed
Schindler C, H xf6 rauf J, Weber B, Schaible I, Marzi I, Henrich D, et al. Identification of novel blood-based extracellular vesicles biomarker candidates with potential specificity for traumatic brain injury in polytrauma patients. Front Immunol. 2024;15:1347767 pubmed publisher
Carreras Mascaro A, Grochowska M, Boumeester V, Dits N, Bilgi x4ab E, Breedveld G, et al. LRP10 and α-synuclein transmission in Lewy body diseases. Cell Mol Life Sci. 2024;81:75 pubmed publisher
Lee K, Beatson E, Knechel M, Sommer E, Napoli G, Risdon E, et al. Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3. J Cancer. 2024;15:615-622 pubmed publisher
Huang C, Zhao Y, Lin S, Li L, Guo X, Yumiseba S, et al. Characterization of human placenta-derived exosome (pExo) as a potential osteoarthritis disease modifying therapeutic. Arthritis Res Ther. 2023;25:229 pubmed publisher
Son J, Weon J, Baek G, Ahn H, Choi J, Yoon M, et al. Circulating small extracellular vesicle-derived splicing factor 3b subunit 4 as a non-invasive diagnostic biomarker of early hepatocellular carcinoma. J Exp Clin Cancer Res. 2023;42:288 pubmed publisher
Soccio P, Moriondo G, Scioscia G, Leo V, Tondo P, Salerno L, et al. Searching for airways biomarkers useful to identify progressive pulmonary fibrosis. BMC Pulm Med. 2023;23:407 pubmed publisher
Takeda N, Tsuchiya A, Mito M, Natsui K, Natusi Y, Koseki Y, et al. Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis. Inflamm Regen. 2023;43:48 pubmed publisher
Bernuz M, Pallar xe8 s Rusi xf1 ol A, Rossi R, Fern xe1 ndez Senac C, Mart xed M, Pividori M. Magnetic Separation of Cell-Secreted Vesicles with Tailored Magnetic Particles and Downstream Applications. Methods Mol Biol. 2023;2668:257-276 pubmed publisher
Cui H, Joo S, Lee S, Cho Y, Kim D, Seo C. Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin. Int J Mol Sci. 2023;24: pubmed publisher
Weber B, Henrich D, Schindler C, Marzi I, Leppik L. Release of exosomes in polytraumatized patients: The injury pattern is reflected by the surface epitopes. Front Immunol. 2023;14:1107150 pubmed publisher
Ta x15f l x131 P. Usage of celery root exosome as an immune suppressant; Lipidomic characterization of apium graveolens originated exosomes and its suppressive effect on PMA/ionomycin mediated CD4+ T lymphocyte activation. J Food Biochem. 2022;46:e14393 pubmed publisher
Casadei L, Sarchet P, de Faria F, Calore F, Nigita G, Tahara S, et al. In situ hybridization to detect DNA amplification in extracellular vesicles. J Extracell Vesicles. 2022;11:e12251 pubmed publisher
Wright A, Snyder O, Christenson L, He H, Weiss M. Effect of Pre-Processing Storage Condition of Cell Culture-Conditioned Medium on Extracellular Vesicles Derived from Human Umbilical Cord-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2022;23: pubmed publisher
C xe9 spedes P, Jainarayanan A, Fern xe1 ndez Messina L, Valvo S, Saliba D, Kurz E, et al. T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles. Nat Commun. 2022;13:3460 pubmed publisher
Cohn W, Zhu C, Campagna J, Bilousova T, Spilman P, Teter B, et al. Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue. Int J Mol Sci. 2022;23: pubmed publisher
Barnes B, Caws T, Thomas S, Shephard A, Corteling R, Hole P, et al. Investigating heparin affinity chromatography for extracellular vesicle purification and fractionation. J Chromatogr A. 2022;1670:462987 pubmed publisher
Anakor E, Milla V, Connolly O, Martinat C, Pradat P, Dumonceaux J, et al. The Neurotoxicity of Vesicles Secreted by ALS Patient Myotubes Is Specific to Exosome-Like and Not Larger Subtypes. Cells. 2022;11: pubmed publisher
Le Gall L, Duddy W, Martinat C, Mariot V, Connolly O, Milla V, et al. Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles. J Cachexia Sarcopenia Muscle. 2022;13:1385-1402 pubmed publisher
Giraud R, Moyon A, Simoncini S, Duchez A, Nail V, Chareyre C, et al. Tracking Radiolabeled Endothelial Microvesicles Predicts Their Therapeutic Efficacy: A Proof-of-Concept Study in Peripheral Ischemia Mouse Model Using SPECT/CT Imaging. Pharmaceutics. 2022;14: pubmed publisher
Hasan H, Sohal I, Soto Vargas Z, Byappanahalli A, Humphrey S, Kubo H, et al. Extracellular vesicles released by non-small cell lung cancer cells drive invasion and permeability in non-tumorigenic lung epithelial cells. Sci Rep. 2022;12:972 pubmed publisher
Phetfong J, Tawonsawatruk T, Kamprom W, Ontong P, Tanyong D, Borwornpinyo S, et al. Bone marrow-mesenchymal stem cell-derived extracellular vesicles affect proliferation and apoptosis of leukemia cells in vitro. FEBS Open Bio. 2022;12:470-479 pubmed publisher
Moura S, Pallar xe8 s Rusi xf1 ol A, Sappia L, Mart xed M, Pividori M. The activity of alkaline phosphatase in breast cancer exosomes simplifies the biosensing design. Biosens Bioelectron. 2022;198:113826 pubmed publisher
Carrascal M, Areny Balaguer xf3 A, de Madaria E, C xe1 rdenas Ja xe9 n K, Garc xed a Rayado G, Rivera R, et al. Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease. J Pathol. 2022;256:83-92 pubmed publisher
Fontaine M, Herkenne S, Ek O, Paquot A, Boeckx A, Paques C, et al. Extracellular Vesicles Mediate Communication between Endothelial and Vascular Smooth Muscle Cells. Int J Mol Sci. 2021;23: pubmed publisher
Penders J, Nagelkerke A, Cunnane E, Pedersen S, Pence I, Coombes R, et al. Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers. ACS Nano. 2021;15:18192-18205 pubmed publisher
Elmore Z, Patrick Havlik L, Oh D, Anderson L, Daaboul G, Devlin G, et al. The membrane associated accessory protein is an adeno-associated viral egress factor. Nat Commun. 2021;12:6239 pubmed publisher
Qi Z, Xue Q, Wang H, Cao B, Su Y, Xing Q, et al. Serum CD203c+ Extracellular Vesicle Serves as a Novel Diagnostic and Prognostic Biomarker for Succinylated Gelatin Induced Perioperative Hypersensitive Reaction. Front Immunol. 2021;12:732209 pubmed publisher
Qi Z, Zhao Y, Su Y, Cao B, Yang J, Xing Q. Serum Extracellular Vesicle-Derived miR-124-3p as a Diagnostic and Predictive Marker for Early-Stage Acute Ischemic Stroke. Front Mol Biosci. 2021;8:685088 pubmed publisher
Xie T, Kulur V, Liu N, Deng N, Wang Y, Rowan S, et al. Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis. Sci Adv. 2021;7: pubmed publisher
Lacedonia D, Scioscia G, Soccio P, Conese M, Catucci L, Palladino G, et al. Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis. BMC Pulm Med. 2021;21:188 pubmed publisher
Li S, Stöckl S, Lukas C, Herrmann M, Brochhausen C, König M, et al. Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1β-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p. Stem Cell Res Ther. 2021;12:252 pubmed publisher
d Alessandro M, Soccio P, Bergantini L, Cameli P, Scioscia G, Foschino Barbaro M, et al. Extracellular Vesicle Surface Signatures in IPF Patients: A Multiplex Bead-Based Flow Cytometry Approach. Cells. 2021;10: pubmed publisher
Yang Z, Wang W, Zhao L, Wang X, Gimple R, Xu L, et al. Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs. Sci Adv. 2021;7: pubmed publisher
Schwartz R, Shokhirev M, Andrade L, Gutkind J, Iglesias Bartolomé R, Shadel G. Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes. Aging (Albany NY). 2021;13:4747-4777 pubmed publisher
Niedermair T, Lukas C, Li S, Stöckl S, Craiovan B, Brochhausen C, et al. Influence of Extracellular Vesicles Isolated From Osteoblasts of Patients With Cox-Arthrosis and/or Osteoporosis on Metabolism and Osteogenic Differentiation of BMSCs. Front Bioeng Biotechnol. 2020;8:615520 pubmed publisher
Li S, Stöckl S, Lukas C, Götz J, Herrmann M, Federlin M, et al. hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways. Front Bioeng Biotechnol. 2020;8:603598 pubmed publisher
Whittaker T, Nagelkerke A, Nele V, Kauscher U, Stevens M. Experimental artefacts can lead to misattribution of bioactivity from soluble mesenchymal stem cell paracrine factors to extracellular vesicles. J Extracell Vesicles. 2020;9:1807674 pubmed publisher
Xu J, Yin Z, Yang L, Wu F, Fan J, Huang Q, et al. Evidence that dysplasia related microRNAs in Barrett's esophagus target PD-L1 expression and contribute to the development of esophageal adenocarcinoma. Aging (Albany NY). 2020;12:17062-17078 pubmed publisher
Arteaga Blanco L, Mojoli A, Monteiro R, Sandim V, Menna Barreto R, Pereira Dutra F, et al. Characterization and internalization of small extracellular vesicles released by human primary macrophages derived from circulating monocytes. PLoS ONE. 2020;15:e0237795 pubmed publisher
Mazumdar A, Urdinez J, Boro A, Migliavacca J, Arlt M, Muff R, et al. Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming. Int J Mol Sci. 2020;21: pubmed publisher
Kwon Y, Nukala S, Srivastava S, Miyamoto H, Ismail N, Rehman J, et al. Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells. bioRxiv. 2020;: pubmed publisher
Kim S, Baek G, Ahn H, Sung S, Seo C, Cho H, et al. Serum small extracellular vesicle-derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma. Mol Oncol. 2020;14:2646-2659 pubmed publisher
Hofmann L, Ludwig S, Schuler P, Hoffmann T, Brunner C, Theodoraki M. The Potential of CD16 on Plasma-Derived Exosomes as a Liquid Biomarker in Head and Neck Cancer. Int J Mol Sci. 2020;21: pubmed publisher
Horgan C, Nagelkerke A, Whittaker T, Nele V, Massi L, Kauscher U, et al. Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling. J Mater Chem B. 2020;8:4447-4459 pubmed publisher
Kauscher U, Penders J, Nagelkerke A, Holme M, Nele V, Massi L, et al. Gold Nanocluster Extracellular Vesicle Supraparticles: Self-Assembled Nanostructures for Three-Dimensional Uptake Visualization. Langmuir. 2020;36:3912-3923 pubmed publisher
Mitchell A, Wanczyk H, JENSEN T, Finck C. Human induced pluripotent stem cells ameliorate hyperoxia-induced lung injury in a mouse model. Am J Transl Res. 2020;12:292-307 pubmed
Perez Boza J, Boeckx A, Lion M, Dequiedt F, Struman I. hnRNPA2B1 inhibits the exosomal export of miR-503 in endothelial cells. Cell Mol Life Sci. 2020;77:4413-4428 pubmed publisher
Vignard V, Labbé M, Marec N, André Grégoire G, Jouand N, Fonteneau J, et al. MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma. Cancer Immunol Res. 2020;8:255-267 pubmed publisher
Xu Z, Zheng X, Zheng J. Tumor-derived exosomes educate fibroblasts to promote salivary adenoid cystic carcinoma metastasis via NGF-NTRK1 pathway. Oncol Lett. 2019;18:4082-4091 pubmed publisher
Kinjyo I, Bragin D, Grattan R, Winter S, Wilson B. Leukemia-derived exosomes and cytokines pave the way for entry into the brain. J Leukoc Biol. 2019;105:741-753 pubmed publisher
Abramowicz A, Marczak L, Wojakowska A, Zapotoczny S, Whiteside T, Widlak P, et al. Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis. PLoS ONE. 2018;13:e0205496 pubmed publisher
Hayashi M, Kuroda K, Ihara K, Iwaya T, Isogai E. Suppressive effect of an analog of the antimicrobial peptide of LL‑37 on colon cancer cells via exosome‑encapsulated miRNAs. Int J Mol Med. 2018;42:3009-3016 pubmed publisher
Che Y, Geng B, Xu Y, Miao X, Chen L, Mu X, et al. Helicobacter pylori-induced exosomal MET educates tumour-associated macrophages to promote gastric cancer progression. J Cell Mol Med. 2018;22:5708-5719 pubmed publisher
Fang H, Shao S, Jiang M, Dang E, Shen S, Zhang J, et al. Proinflammatory role of blister fluid-derived exosomes in bullous pemphigoid. J Pathol. 2018;245:114-125 pubmed publisher
Perez Boza J, Lion M, Struman I. Exploring the RNA landscape of endothelial exosomes. RNA. 2017;: pubmed publisher
Stolzenburg L, Harris A. Microvesicle-mediated delivery of miR-1343: impact on markers of fibrosis. Cell Tissue Res. 2018;371:325-338 pubmed publisher
Bonjoch L, Gironella M, Iovanna J, Closa D. REG3β modifies cell tumor function by impairing extracellular vesicle uptake. Sci Rep. 2017;7:3143 pubmed publisher
Kamalden T, Macgregor Das A, Kannan S, Dunkerly Eyring B, Khaliddin N, Xu Z, et al. Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress. Antioxid Redox Signal. 2017;27:913-930 pubmed publisher
Stetler Stevenson M, Paiva B, Stoolman L, Lin P, Jorgensen J, Orfao A, et al. Consensus guidelines for myeloma minimal residual disease sample staining and data acquisition. Cytometry B Clin Cytom. 2016;90:26-30 pubmed publisher
Dráber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, et al. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. Mol Cell Biol. 2011;31:4550-62 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD81 Monoclonal Antibody (M38)
Catalog # :
10630D
Quantity :
200 uL
Price :
US 336.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Western Blot: Assay-dependent
Species :
Human
Clone :
M38
Isotype :
IgG1
Storage :
4 C
Description :
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
Immunogen :
MOLT-4 (human T-ALL cell line)
Format :
Liquid
Applications w/Dilutions :
Western Blot: Assay-dependent
Aliases :
26 kDa cell surface protein TAPA-1; CD 81 antigen; Cd81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CD81 molecule; CVID6; S5.7; Tapa1; Tapa-1; Target of the antiproliferative antibody 1; Tetraspanin28; tetraspanin-28; Tspan28; Tspan-28
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA