This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human PDGF-AB Recombinant Protein, PeproTech
catalog :
100-00AB-2UG
quantity :
2 ug
price :
US 93.50
citations: 45
Reference
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Meier S, Cantilena S, Niklison Chirou M, Anderson J, Hargrave D, Salomoni P, et al. Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation. Cell Death Dis. 2021;12:785 pubmed publisher
Geuder J, Wange L, Janjić A, Radmer J, Janssen P, Bagnoli J, et al. A non-invasive method to generate induced pluripotent stem cells from primate urine. Sci Rep. 2021;11:3516 pubmed publisher
Gillies T, Pargett M, Silva J, Teragawa C, McCormick F, Albeck J. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. 2020;16:e9518 pubmed publisher
Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, et al. RAB31 marks and controls an ESCRT-independent exosome pathway. Cell Res. 2021;31:157-177 pubmed publisher
Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, et al. Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming. Cell Rep. 2020;32:107870 pubmed publisher
Nzou G, Wicks R, VanOstrand N, Mekky G, Seale S, El Taibany A, et al. Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction. Sci Rep. 2020;10:9766 pubmed publisher
Liao W, Liao C, Tseng T, Ho Y, Chen Y, Lin K, et al. Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability. Oncogenesis. 2020;9:9 pubmed publisher
Channakkar A, Singh T, Pattnaik B, Gupta K, Seth P, Adlakha Y. MiRNA-137-mediated modulation of mitochondrial dynamics regulates human neural stem cell fate. Stem Cells. 2020;38:683-697 pubmed publisher
Ellefsen K, Holt J, Chang A, Nourse J, Arulmoli J, Mekhdjian A, et al. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers. Commun Biol. 2019;2:298 pubmed publisher
Faroni A, Workman V, Saiani A, Reid A. Self-Assembling Peptide Hydrogel Matrices Improve the Neurotrophic Potential of Human Adipose-Derived Stem Cells. Adv Healthc Mater. 2019;8:e1900410 pubmed publisher
Mahjour F, Dambal V, Shrestha N, Singh V, Noonan V, Kantarci A, et al. Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB. Oncogenesis. 2019;8:34 pubmed publisher
Takizawa H, Hara Y, Mizobe Y, Ohno T, Suzuki S, Inoue K, et al. Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride. Sci Rep. 2019;9:3807 pubmed publisher
Park M, Cho H, Roh S, Kim S, Myoung J. Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication. Sci Rep. 2019;9:2372 pubmed publisher
Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, et al. PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nat Commun. 2018;9:3439 pubmed publisher
Nzou G, Wicks R, Wicks E, Seale S, Sane C, Chen A, et al. Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. Sci Rep. 2018;8:7413 pubmed publisher
Mahadik K, Prakhar P, Rajmani R, Singh A, Balaji K. c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a. Front Immunol. 2018;9:85 pubmed publisher
de la Torre Ubieta L, Stein J, Won H, Opland C, Liang D, Lu D, et al. The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis. Cell. 2018;172:289-304.e18 pubmed publisher
Wu X, Dao Thi V, Huang Y, Billerbeck E, Saha D, Hoffmann H, et al. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018;172:423-438.e25 pubmed publisher
Osborne A, Sanderson J, Martin K. Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells. Stem Cells. 2017;: pubmed publisher
Ghazanfari R, Zacharaki D, Li H, Ching Lim H, Soneji S, Scheding S. Human Primary Bone Marrow Mesenchymal Stromal Cells and Their in vitro Progenies Display Distinct Transcriptional Profile Signatures. Sci Rep. 2017;7:10338 pubmed publisher
Govaere O, Petz M, Wouters J, Vandewynckel Y, Scott E, Topal B, et al. The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma. Oncogene. 2017;36:6605-6616 pubmed publisher
Li X, Zhang Y, Liang Y, Cui Y, Yeung S, Ip M, et al. iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells. J Cell Mol Med. 2017;21:265-277 pubmed publisher
Chong R, Osborne A, Concei xe7 xe3 o R, Martin K. Platelet-Derived Growth Factor Preserves Retinal Synapses in a Rat Model of Ocular Hypertension. Invest Ophthalmol Vis Sci. 2016;57:842-52 pubmed publisher
Lee D, Su J, Kim H, Chang B, Papatsenko D, Zhao R, et al. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015;161:240-54 pubmed publisher
Pathak M, Nourse J, Tran T, Hwe J, Arulmoli J, Le D, et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014;111:16148-53 pubmed publisher
Duan C, Shi J, Chen J, Wang B, Yu Y, Qin X, et al. Leukemia propagating cells rebuild an evolving niche in response to therapy. Cancer Cell. 2014;25:778-93 pubmed publisher
Martino M, Briquez P, Ranga A, Lutolf M, Hubbell J. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc Natl Acad Sci U S A. 2013;110:4563-8 pubmed publisher
Roubelakis M, Tsaknakis G, Pappa K, Anagnou N, Watt S. Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS ONE. 2013;8:e54747 pubmed publisher
Petz M, Them N, Huber H, Mikulits W. PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res. 2012;40:9738-49 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Wong R, Pera M, Pebay A. Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor. Methods Mol Biol. 2012;874:167-75 pubmed publisher
Ekert J, Murray L, Das A, Sheng H, Giles Komar J, Rycyzyn M. Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes. Fibrogenesis Tissue Repair. 2011;4:23 pubmed publisher
Cardoso L, Little P, Ballinger M, Chan C, Braun K, Potter Perigo S, et al. Platelet-derived growth factor differentially regulates the expression and post-translational modification of versican by arterial smooth muscle cells through distinct protein kinase C and extracellular signal-regulated kinase pathways. J Biol Chem. 2010;285:6987-95 pubmed publisher
Wexler E, Paucer A, Kornblum H, Palmer T, Geschwind D. Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells. 2009;27:1130-41 pubmed publisher
Blagoveshchenskaya A, Cheong F, Rohde H, Glover G, Knödler A, Nicolson T, et al. Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J Cell Biol. 2008;180:803-12 pubmed publisher
Schuster K, Martens M, Goldenberg M, Tai C, Strande L, Hewitt C. Production of a novel fibroblast-populated platelet matrix cocultured with keratinocytes. Tissue Eng. 2007;13:1493-500 pubmed
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
Lian Q, Lye E, Suan Yeo K, Khia Way Tan E, Salto Tellez M, Liu T, et al. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells. 2007;25:425-36 pubmed
Soen Y, Mori A, Palmer T, Brown P. Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol Syst Biol. 2006;2:37 pubmed
Pebay A, Wong R, Pitson S, Wolvetang E, Peh G, Filipczyk A, et al. Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. Stem Cells. 2005;23:1541-8 pubmed
Sommer U, Schmid C, Sobota R, Lehmann U, Stevenson N, Johnston J, et al. Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases. J Biol Chem. 2005;280:31478-88 pubmed
Tsai J, Liu L, Guan J, Aird W. The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells. Am J Physiol Cell Physiol. 2000;279:C1414-24 pubmed
Zhang B, Yeh C, Hymer T, Lifschitz M, Katz M. EGF inhibits muscarinic receptor-mediated calcium signaling in a human salivary cell line. Am J Physiol Cell Physiol. 2000;279:C1024-33 pubmed
product information
Product Type :
Protein
Product Name :
Human PDGF-AB Recombinant Protein, PeproTech
Catalog # :
100-00AB-2UG
Quantity :
2 ug
Price :
US 93.50
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
Functional Assay: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
Platelet-Derived Growth Factor (PDGF) is a mitogenic peptide growth hormone carried in the alpha-granules of platelets and is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. The synthesis of PDGF can be induced by IL-1, IL-6, TNF-alpha, TGF-beta and EGF.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
Becaplermin; c-sis; H-PDGF-AB; IBGC5; PDGF A-chain; PDGF subunit A; PDGF subunit B; PDGF, B chain; PDGF1; PDGF-1; PDGF2; PDGF-2; Pdgfa; PDGF-A; PDGFAB; PDGFB; PDGF-B; platelet derived growth factor subunit A; platelet derived growth factor subunit B; platelet derived growth factor, alpha; platelet derived growth factor, B polypeptide; platelet-derived growth factor 2; platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit A; Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); proto-oncogene c-Sis; SIS; SSV
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA