CD34 Monoclonal Antibody (BI-3C5) | Invitrogen 07-3403 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD34 Monoclonal Antibody (BI-3C5)

catalog :

07-3403

quantity :

100 µg

price :

US 450

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BI-3C5

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; fig 1	Li S, Jing F, Ma L, Guo L, Na F, An S, et al. Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease. Drug Des Devel Ther. 2015;9:4649-56 pubmed publisher
immunohistochemistry - paraffin section; human	Ye J, Vives Pi M, Gillespie K. Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. PLoS ONE. 2014;9:e86985 pubmed publisher
immunohistochemistry; human; fig 2	Yang G, Li J, Jin H, Ding H. Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study. Diagn Pathol. 2013;8:14 pubmed publisher
western blot; human; 1:1500	Nordgaard C, Karunadharma P, Feng X, Olsen T, Ferrington D. Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:2848-55 pubmed publisher
immunohistochemistry; human; 1:50	Cao Y, Zhang M, Wang J, Zhang W, Li G, Zhao J. Recurrent intracranial hemangiopericytoma with multiple metastases. Chin Med J (Engl). 2006;119:169-73 pubmed
	Zhang P, Ono A, Fujii Y, Hayes C, Tamura Y, Miura R, et al. The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma. Int J Cancer. 2022;151:2278-2290 pubmed publisher
	Margaritis M, Saini F, Baranowska Clarke A, Parsons S, Vink A, Budgeon C, et al. Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc Res. 2022;118:1835-1848 pubmed publisher
	Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P, et al. Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium. Genome Biol. 2020;21:64 pubmed publisher
	Sheng W, Chauhan P, Hu S, Prasad S, Lokensgard J. Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Pain Res Manag. 2019;2019:1260353 pubmed publisher
	Mitroi M, Albulescu D, Căpitănescu A, Docea A, Muşat G, Mitroi G, et al. Differences in the distribution of CD20, CD3, CD34 and CD45RO in nasal mucosa and polyps from patients with chronic rhinosinusitis. Mol Med Rep. 2019;19:2792-2800 pubmed publisher
	Wimmer R, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505-510 pubmed publisher
	Sanchez V, Villalba N, Fiore L, Luzzani C, Miriuka S, Boveris A, et al. Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells. An Intercellular Exchange of Components between Neighboring Cells. Stem Cell Rev. 2017;13:491-498 pubmed publisher
	Li S, Tay D, Shu S, Bao X, Wu Y, Wang X, et al. Endothelial nitric oxide synthase is expressed in amacrine cells of developing human retinas. Invest Ophthalmol Vis Sci. 2006;47:2141-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD34 Monoclonal Antibody (BI-3C5)

Catalog # :

07-3403

Quantity :

100 µg

Price :

US 450

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1:25-1:50, Immunohistochemistry: Assay-dependent, Western Blot: 1:500-1:2,000

Species :

Human

Clone :

BI-3C5

Isotype :

IgG1

Storage :

-20°C

Description :

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

Immunogen :

to the human CD4

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:25-1:50, Immunohistochemistry: Assay-dependent, Western Blot: 1:500-1:2,000

Aliases :

(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1

more info or order :

Invitrogen product webpage