Phosphotyrosine Monoclonal Antibody (pY20), AP | Invitrogen 03-7722 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phosphotyrosine Monoclonal Antibody (pY20), AP

catalog :

03-7722

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

PY20

application :

western blot, ELISA

citations: 8

Reference
Goyal L, Saha S, Liu L, Siravegna G, Leshchiner I, Ahronian L, et al. Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma. Cancer Discov. 2017;7:252-263 pubmed publisher
Skora L, Kempf D, Mestan J, D Orazio D, Jahnke W. Phosphorylation of Tyr245 in the open-inhibited state of Abelson kinase does not induce downstream signaling. Eur J Haematol. 2016;96:502-6 pubmed publisher
Cicenas J, Küng W, Eppenberger U, Eppenberger Castori S. Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor. Cancers (Basel). 2010;2:153-64 pubmed publisher
Skora L, Mestan J, Fabbro D, Jahnke W, Grzesiek S. NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors. Proc Natl Acad Sci U S A. 2013;110:E4437-45 pubmed publisher
Martiny Baron G, Holzer P, Billy E, Schnell C, Brueggen J, Ferretti M, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010;13:259-67 pubmed publisher
Digan M, Pou C, Niu H, Zhang J. Evaluation of division-arrested cells for cell-based high-throughput screening and profiling. J Biomol Screen. 2005;10:615-23 pubmed
Traxler P, Allegrini P, Brandt R, Brueggen J, Cozens R, Fabbro D, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004;64:4931-41 pubmed
Garcia Echeverria C, Pearson M, Marti A, Meyer T, Mestan J, Zimmermann J, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004;5:231-9 pubmed

product information

Product Type :

Antibody

Product Name :

Phosphotyrosine Monoclonal Antibody (pY20), AP

Catalog # :

03-7722

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Chemical

Applications :

ELISA: Assay-dependent, Western Blot: 1:1,000

Species :

Chemical

Clone :

pY20

Isotype :

IgG2b

Storage :

-20 C

Description :

The role of tyrosine phosphorylation in transduction of the mitogenic signal from transmembrane receptors and in transformation by oncogene tyrosine kinases has been the subject of intense investigation for several years. While the phosphorylation of specific tyrosine residues has been shown to be a primary mechanism of signal transduction during normal mitogenesis, cell cycle progression and oncogenic transformation, its role in other areas such as differentiation and gap junction communication, is a matter of active and ongoing research. Antibodies that specifically recognize phosphorylated tyrosine residues have proved to be invaluable to the study of tyrosine -phosphorylated proteins and the biochemical pathways in which they function. The fluorescein (FITC) conjugate of clone PY20 anti-phosphotyrosine is especially useful for the detection of these P-Tyr proteins in immunohistochemical and immunocytochemical protocols in situations wherein the use of a secondary antibody would complicate detection of the protein(s) of interest.

Immunogen :

Keyhole limpet hemocyanin coupled with equal amounts of phosphotyrosine, glycine, and alanine

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 1:1,000

Aliases :

Phosphotyrosine; pTyr; pY