Collagen type I (¾ fragment, C-terminal cleavage site, Gly775–Ile776 / Gly775–Leu776)

product summary

company name :

Immunoglobe

product type :

antibody

product name :

Collagen type I (¾ fragment, C-terminal cleavage site, Gly775–Ile776 / Gly775–Leu776)

catalog :

0217-050

quantity :

200 µl, 50 µg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow, rabbit

application :

immunocytochemistry

more info or order :

Immunoglobe product webpage

citations: 9

Reference
Lodillinsky C, Infante E, Guichard A, Chaligne R, Fuhrmann L, Cyrta J, et al. p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer. Oncogene. 2016;35:344-57 pubmed publisher
Arora P, Wang Y, Bresnick A, Janmey P, McCulloch C. Flightless I interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling. Mol Biol Cell. 2015;26:2279-97 pubmed publisher
Marchesin V, Castro-Castro A, Lodillinsky C, Castagnino A, Cyrta J, Bonsang-Kitzis H, et al. ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion. J Cell Biol. 2015;211:339-58 pubmed publisher
Gligorijevic B, Bergman A, Condeelis J. Multiparametric classification links tumor microenvironments with tumor cell phenotype. PLoS Biol. 2014;12:e1001995 pubmed publisher
Juin A, Di Martino J, Leitinger B, Henriet E, Gary A, Paysan L, et al. Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway. J Cell Biol. 2014;207:517-33 pubmed publisher
Monteiro P, Rosse C, Castro-Castro A, Irondelle M, Lagoutte E, Paul-Gilloteaux P, et al. Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol. 2013;203:1063-79 pubmed
Ilina O, Bakker G, Vasaturo A, Hofmann R, Friedl P. Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion. Phys Biol. 2011;8:015010 pubmed publisher
Orgaz J, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, et al. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun. 2014;5:4255 pubmed publisher
Wolf K, Te Lindert M, Krause M, Alexander S, Te Riet J, Willis A, et al. Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol. 2013;201:1069-84 pubmed publisher

product information

CATALOG NO :

0217-050

NAME (Link To Web Site) :

C o l 1 - ¾ C

SPECIFICITY :

Collagen type I (¾ fragment, C-terminal cleavage site, Gly775–Ile776 / Gly775–Leu776)

OTHER NAMES :

Col1-¾C, Col(I)-¾C, Col1A1-¾C, Col1A2-¾C, Collagen (I) (¾ fragment, C-terminal cleavage site, Gly775–Ile776 / Gly775–Leu776), Collagen type I (¾ fragment, C-terminal cleavage site, Gly775–Ile776 / Gly775–Leu776), Collagen type 1 (¾ fragment, C-terminal cleavage site, Gly775–Ile776 / Gly775–Leu776)

UniProt / Swiss-Prot # :

P02452, O76045, Q9UMM7, P08123, P02453, P02465, P02457, P02467, Q28668, P11087, P02454, Q9XSJ7, O46392

CLONE/Poly-clonal :

polyclonal

HOST SPECIES :

RABBIT

reactive species :

tested: rat, cow; sequence identity: Chinese hamster, guinea pig, dog, cat, donkey, pig, sheep, chicken

FORMAT/CONJUGATES :

affinity purified on the antigen

SIZE :

200 µl, 50 µg

DESCRIPTION :

The antibody recognizes the C-terminal end of the N-terminal three quarter collagen fragment (Col1 ¾), which results from MT1-MMP, MMP-1, MMP-2, or MMP-8 dependent cleavage of the α 1 (I) and α 2 (I) chains at the G775–I776 & G775–L776 bonds, respectively

APPLICATIONS :

IF - immunofluorescence

SAMPLE APPLICATIONS :

(see EXTRANET)

SUGGESTED DILUTIONS :

IF: 2.5 µg/ml - 10 µg/ml

[PubMed-Id; PMID] :

24344185, 25422375, 23798731, 21301056, 26504170, 25877872, 25386698, 24963846, 25893299

Updated :

6/16/16

more info or order :

Immunoglobe product webpage