product summary
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company name :
Immunoglobe
product type :
antibody
product name :
NFATc2, NFATp
catalog :
0112-02
quantity :
100 µl, 20 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation
more info or order :
citations: 11
Reference
Patra A, Avots A, Zahedi R, Schüler T, Sickmann A, Bommhardt U, et al. An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol. 2013;14:127-35 pubmed publisher
Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2012;109:16258-63 pubmed publisher
Gerlach K, Daniel C, Lehr H, Nikolaev A, Gerlach T, Atreya R, et al. Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis. Cancer Res. 2012;72:4340-50 pubmed publisher
Bhattacharyya S, Deb J, Patra A, Thuy Pham D, Chen W, Vaeth M, et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med. 2011;208:823-39 pubmed publisher
Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang S, Cahalan M, et al. Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity. 2010;33:723-35 pubmed publisher
Zanoni I, Ostuni R, Capuano G, Collini M, Caccia M, Ronchi A, et al. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature. 2009;460:264-8 pubmed publisher
Huber M, Brüstle A, Reinhard K, Guralnik A, Walter G, Mahiny A, et al. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A. 2008;105:20846-51 pubmed publisher
Klein Hessling S, Bopp T, Jha M, Schmidt A, Miyatake S, Schmitt E, et al. Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter. J Biol Chem. 2008;283:31030-7 pubmed publisher
Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg M, et al. Autoregulation of Th1-mediated inflammation by twist1. J Exp Med. 2008;205:1889-901 pubmed publisher
Ullerås E, Karlberg M, Möller Westerberg C, Alfredsson J, Gerondakis S, Strasser A, et al. NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells. Blood. 2008;111:3081-9 pubmed publisher
Akimzhanov A, Krenacs L, Schlegel T, Klein Hessling S, Bagdi E, Stelkovics E, et al. Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling. Am J Pathol. 2008;172:215-24 pubmed
product information
CATALOG NO :
0112-02
NAME (Link To Web Site) :
IG-209
SPECIFICITY :
NFATc2, NFATp
OTHER NAMES :
NFATc2, NF-ATc2, NF-ATp, NFAT pre-existing subunit, Nfat1, NFATp, Nuclear factor of activated T-cells c2, Nuclear factor of activated T-cells cytoplasmic 2, T-cell transcription factor NFAT1
UniProt / Swiss-Prot # :
Q60591, A2APK2, Q91Y65
CLONE/Poly-clonal :
polyclonal
HOST SPECIES :
RABBIT
reactive species  :
human
FORMAT/CONJUGATES :
affinity purified on the antigen
SIZE :
100 µl, 20 µg
DESCRIPTION :
antibody raised against recombinant protein (full-length sequence); works with formaldehyde fixed cells and tissues (IF, IHC)
APPLICATIONS :
WB - Western blot / immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry, IP - immunoprecipitation, ChIP - chromatin immunoprecipitation
SUGGESTED DILUTIONS :
WB: (1:500); IF: (1:50); IP: (1:100); ChIP (1:100)
[PubMed-Id; PMID] :
18156209, 21464221, 21093319, 22738913, 17082579, 18772129, 18663125, 23263556, 18182578, 22991461, 19525933, 19088203
Updated :
4/26/13
more info or order :
company information
Immunoglobe
info@immunoGlobe.com
www.immunoglobe.com