antibody

Amyloidβ (1-40) Anti-Human Rabbit IgG Affinity Purify

18580

50 µg

499 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry

Amyloidβ (1-40) Anti-Human Rabbit IgG Affinity Purify

Alzheimer’s Disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles(NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide(Aβ), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by β-secretase and a putative γ-secretase. Increased release of the ‘longer forms’ of Aβ peptide, Aβ42 or Aβ43, which have a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alles, or may involve other, still undiscovered, factors, Many researchers theorize that it is this increased release of Aβ42/Aβ43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.

Anti-Human

Rabbit

IHC, WB.

Polyclonal

Synthetic peptide for C-terminal of Human Amyloidβ (1-40) (MVGGVV).

Amyloid beta, A-beta, Aβ.

Affinity Purified with antigen peptide.

Human Amyloidβ (1-40) specific. Not cross-react with human Amyloidβ (1-42) or (1-43).

Lyophilized product, 5 years at 2 - 8°C; Solution, 2 years at -20°C.

Lyophilized product from 1% BSA in PBS containing 0.05%NaN3.

50 µg

499 USD

For research use only, not for use in diagnostic procedures.