Rb1 Antibody [1F8] | ImmuQuest IQ610 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ImmuQuest

product type :

antibody

product name :

Rb1 Antibody [1F8]

catalog :

IQ610

quantity :

0.1 ml

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

'1F8

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

product information

Product Name :

Rb1 Antibody [1F8]

Target Antigen :

Rb1

Primary Description :

Mouse anti Rb1 [1F8]

Catalogue Number :

IQ610

Quantity :

0.1 ml

Concentration :

1mg/ml

Clone :

'1F8

Host :

Mouse

Isotype :

IgG1

Immunogen :

Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 of human Rb gel purified from bacterial lysates

Myeloma/fusion partners :

Cells from immunized Balb/c mice were fused with the Sp2/0-Ag.14 myeloma cell line

Specificity :

This antibody recognises retinoblastoma-associated protein (RB), a 105kDa tumour suppressor which is also known as Rb1. Rb1 functions as a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma.

Species Reactivity :

Mouse, Human

Purification :

Purified on protein A from tissue culture supernatant.

Format :

Purified IgG supplied in Phosphate buffered saline (PBS) containing 0.09% Sodium azide

Applications :

ICC/IF, IHC-Fr, IP, WB

Dilutions :

Optimal antibody dilution should be determined by titration

References :

BÃ¡rtek J, et al. Cellular localization and T antigen binding of the retinoblastoma protein. Oncogene.1992.7(1):101-8. PMID:1741157 http://www.ncbi.nlm.nih.gov/pubmed/1741157

Database links :

Entrez Gene: 5925 Human; Entrez Gene: 19645 Mouse; Omim: 614041 Human; SwissProt: P06400 Human; SwissProt: P13405 Mouse; Unigene: 408528 Human; Unigene: 273862 Mouse

Research areas :

Epigenetics; Cell cycle; Tumour supressor

Also known as :

OSRC; p105-Rb; pp110; pRb; Rb; RB1; retinoblastoma 1; retinoblastoma suspectibility protein; Retinoblastoma-associated protein

Price (Pounds) :

226

Price (Dollars) :

345 USD

Price (Euros) :

338