product summary
company name :
Hycult Biotech
product type :
antibody
product name :
LPScore, mAb WN1 222-5, immuno assay antibody
catalog :
HM6011-IA
quantity :
0.5 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
WN1 222-5
application :
western blot, immunohistochemistry - paraffin section
more info or order :
Hycult Biotech product webpage
citations: 17
Reference
Falchi F, Maccagni E, Puccio S, Peano C, De Castro C, Palmigiano A, et al. Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli. J Bacteriol. 2018;200: pubmed publisher
Belcher J, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash A, et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood. 2014;123:377-90 pubmed publisher
Ruan X, Valvano M. In vitro O-antigen ligase assay. Methods Mol Biol. 2013;1022:185-97 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, et al. Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs. Int Immunol. 2012;24:495-506 pubmed publisher
Laplante P, Amireault P, Subang R, Dieudé M, Levine J, Rauch J. Interaction of ?2-glycoprotein I with lipopolysaccharide leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages. J Biol Chem. 2011;286:42494-503 pubmed publisher
Klatt N, Harris L, Vinton C, Sung H, Briant J, Tabb B, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol. 2010;3:387-98 pubmed publisher
Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int Immunol. 2010;22:271-80 pubmed publisher
Sperandeo P, Lau F, Carpentieri A, De Castro C, Molinaro A, Dehò G, et al. Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli. J Bacteriol. 2008;190:4460-9 pubmed publisher
Mochida S, Matsura T, Yamashita A, Horie S, Ohata S, Kusumoto C, et al. Geranylgeranylacetone ameliorates inflammatory response to lipopolysaccharide (LPS) in murine macrophages: inhibition of LPS binding to the cell surface. J Clin Biochem Nutr. 2007;41:115-23 pubmed publisher
Tsuneyoshi N, Kohara J, Bahrun U, Saitoh S, Akashi S, Gauchat J, et al. Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction. Cell Immunol. 2006;244:57-64 pubmed
Sperandeo P, Cescutti R, Villa R, Di Benedetto C, Candia D, Dehò G, et al. Characterization of lptA and lptB, two essential genes implicated in lipopolysaccharide transport to the outer membrane of Escherichia coli. J Bacteriol. 2007;189:244-53 pubmed
Kohara J, Tsuneyoshi N, Gauchat J, Kimoto M, Fukudome K. Preparation and characterization of truncated human lipopolysaccharide-binding protein in Escherichia coli. Protein Expr Purif. 2006;49:276-83 pubmed
Kobayashi M, Saitoh S, Tanimura N, Takahashi K, Kawasaki K, Nishijima M, et al. Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. J Immunol. 2006;176:6211-8 pubmed
Tada R, Nagi Miura N, Adachi Y, Ohno N. Candida albicans derived fungal PAMPS, CAWS, water soluble mannoprotein-beta-glucan complex shows similar immunotoxicological activity with bacterial endotoxin from Escherichia coli O9. Biol Pharm Bull. 2006;29:240-6 pubmed
Koraha J, Tsuneyoshi N, Kimoto M, Gauchat J, Nakatake H, Fukudome K. Comparison of lipopolysaccharide-binding functions of CD14 and MD-2. Clin Diagn Lab Immunol. 2005;12:1292-7 pubmed
Tsuneyoshi N, Fukudome K, Kohara J, Tomimasu R, Gauchat J, Nakatake H, et al. The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J Immunol. 2005;174:340-4 pubmed
product information
Catalog no :
HM6011-IA
Title :
LPScore, mAb WN1 222-5, immuno assay antibody
Clone no :
WN1 222-5
Quantity :
0.5 mg
Application code :
functional studies,immunoassays,paraffin sections,western blot
Host species :
mouse
Isotype :
IgG2a
Conjugate :
purified
more info or order :
Hycult Biotech product webpage
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
http://www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.