product summary
company name :
Hycult Biotech
product type :
antibody
product name :
Shigatoxin 2, mAb 11E10
catalog :
HM6008
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
11E10
reactivity :
Bacteriophage VT2-Sa
application :
western blot
more info or order :
Hycult Biotech product webpage
citations: 6
Reference
Russo L, Melton-Celsa A, Smith M, Smith M, O'Brien A. Oral intoxication of mice with Shiga toxin type 2a (Stx2a) and protection by anti-Stx2a monoclonal antibody 11E10. Infect Immun. 2014;82:1213-21 pubmed publisher
Grande K, Meysick K, Rasmussen S, O'BRIEN A. Cytotoxic necrotizing factor type 1-neutralizing monoclonal antibody NG8 recognizes three amino acids in a C-terminal region of the toxin and reduces toxin binding to HEp-2 cells. Infect Immun. 2009;77:170-9 pubmed publisher
Li R, Harada T, Honjoh K, Miyamoto T. Phylogenetic analysis and Shiga toxin production profiling of Shiga toxin-producing/enterohemorrhagic Escherichia coli clinical isolates. Microb Pathog. 2010;49:246-51 pubmed publisher
Higashi N, Matsumura Y, Mizuno F, Kasahara K, Sugiura S, Mikasa K, et al. Enhanced expression of ATP-binding cassette transporter A1 in non-rafts decreases the sensitivity of vascular endothelial cells to Shiga toxin. Microb Pathog. 2010;49:141-52 pubmed publisher
Smith M, Teel L, Carvalho H, Melton-Celsa A, O'BRIEN A. Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2. Vaccine. 2006;24:4122-9 pubmed
Smith M, Carvalho H, Melton-Celsa A, O'BRIEN A. The 13C4 monoclonal antibody that neutralizes Shiga toxin Type 1 (Stx1) recognizes three regions on the Stx1 B subunit and prevents Stx1 from binding to its eukaryotic receptor globotriaosylceramide. Infect Immun. 2006;74:6992-8 pubmed
product information
Catalog no :
HM6008
Title :
Shigatoxin 2, mAb 11E10
Clone no :
11E10
Quantity :
100 µg
Application code :
functional studies,immunoassays,western blot
Host species :
mouse
Isotype :
IgG1
Conjugate :
purified
Aliases :
Verotoxin 2
Type :
mAb
Antigen :
Shigatoxin 2
Meta data :
Verotoxin 1, SLT, EHEC, Gb3
more info or order :
Hycult Biotech product webpage
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.